Comparison of Systemic Immune-Inflammation Index and Naples Prognostic Score for Prediction Coronary Artery Severity Patients Undergoing Coronary Computed Tomographic Angiography

Özkan, Eyüp; Erdoğan, Aslan; Karagöz, Ali; Tanboğa, İbrahi̇m Hali̇l

doi:10.1177/00033197231170979

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…19 Similarly, in coronary artery disease, which is fundamentally based on chronic inflammation, NPS is thought to be associated with atherosclerotic burden. 27 Indeed, in two different studies with a high number of patients treated for ST-elevation myocardial infarction (STEMI), high NPS was documented to significantly increase both in-hospital and long-term mortality during a median follow-up of 43 months. 17,28 In another study involving 2901 STEMI patients treated with primary percutaneous intervention, the NPS score was claimed to predict postprocedural AKI.…”

Section: Discussionmentioning

confidence: 99%

The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation

Hakgor,

Dursun,

Kahraman

et al. 2024

Journal of Cardiovascular Medicine

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Background Preoperative systemic inflammation and nutritional status have been shown to affect prognosis in patients undergoing transcatheter aortic valve implantation (TAVI). In this study, we investigated the effect of the Naples Prognostic Score (NPS), which consists of four different parameters including these two components on short- and long-term prognosis in patients undergoing TAVI. Methods In 343 patients (mean age 78.1 ± 8.4 years, 51.3% female) who underwent TAVI, the NPS score was calculated from the blood tests obtained before the procedure and the study population was divided into three according to the NPS value: those with 0 and 1 were divided into Group-1, those with 2 into Group-2, and those with 3 and 4 into Group-3. The relationship between NPS group and in-hospital adverse events and long-term survival was evaluated. Results Systolic pulmonary artery pressure, STS score, presence of chronic lung disease and being in NPS Group-3 [adjusted odds ratio (adjOR): 3.93, 95% confidence interval (CI) (1.02–15.17), P = 0.047] were found to be independent predictors of in-hospital mortality. According to the multivariate Cox-regression model, both Group-2 NPS [adjusted hazard ratio (adjHR): 4.81, 95% CI (1.09–21.14), P = 0.037] and Group-3 NPS [adjHR: 10.1, 95% CI (2.31–43.36), P = 0.002] was an independent predictor of 2-year all-cause mortality after TAVI. There was no significant difference in perioperative adverse events between the groups except for postprocedural acute kidney injury. According to receiver-operating characteristic analysis, the optimal predictive value of NPS for in-hospital and long-term mortality was 2.5. Conclusion In patients who will be candidates for TAVI, NPS is a simple and effective tool for determining both short- and long-term prognosis.

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Section: Discussionmentioning

confidence: 99%

The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation

Hakgor,

Dursun,

Kahraman

et al. 2024

Journal of Cardiovascular Medicine

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“…Moreover, Ozkan et al 19 Major observational studies and randomized controlled trials have identified some independent predictors of in-hospital and longterm mortality for patients with severe AS who underwent TAVR. 1,4,6,17,26 Previously, Lauridsen et al reported that among patients undergoing TAVR, an increasing risk of exacerbation with chronic obstructive pulmonary disease was associated with increasing 1-year mortality compared with non-chronic obstructive pulmonary disease patients.…”

Section: Discussionmentioning

confidence: 99%

“…8,15,16 Additionally, malnutrition has also been associated with mortality, morbidity, and disease severity in cardiovascular disease. 6,10,13,14,[17][18][19][20][21] Recently, several investigators have reported that malnutrition is a predictor of worse outcomes in patients with severe AS undergoing surgical aortic valve replacement. 14,22 Likewise, Sudo et al have recently shown that patients with low nutritional status were more likely to have right-sided heart overload and exhibited an increased risk of 3-year mortality.…”

Section: Discussionmentioning

confidence: 99%

“…have compared the NPS with several inflammatory markers in predicting coronary artery severity. They reported that the several inflammatory markers had a better full range of probability of clinical net benefit compared with the baseline model (odds ratio: 5.77, 95%CI: 4.15-8.02, p < 0.001) 19. However, adding the NPS (p = 0.11) to the model did not outperform the basic statistical model.…”

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confidence: 98%

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Clinical implication of the Naples prognostic score on transcatheter aortic valve replacement in patients with severe aortic stenosis

Demirci,

Aslan,

Güner

et al. 2023

Cathet Cardio Intervent

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BackgroundOne of the hallmarks of frailty in patients with severe aortic stenosis (AS) is malnutrition, for which one of the most up‐to‐date scoring systems is the Naples prognostic score (NPS). This study sought to investigate the predictive role of the NPS in determining mortality in patients undergoing transcatheter aortic valve replacement (TAVR) under long‐term follow‐up.MethodsA total of 430 consecutive patients with symptomatic severe AS who underwent TAVR were included retrospectively. The primary endpoint of the study was the long‐term all‐cause mortality. The study population was divided into two groups according to the NPS value, including Group 1 (NPS 0–2) and Group 2 (NPS 3–4).ResultsThe all‐cause mortality occurred in 250 patients (62.5%) patients during a follow‐up time of 40.6 (22.0–69.4) months. During the follow‐up period, all‐cause mortality was higher in Group 2 compared with Group 1 (87.9% vs. 42.9%, p < 0.001). Older age (p < 0.001), chronic obstructive pulmonary disease (p = 0.015), left ventricular ejection fraction (p = 0.021), and being in Group 2 (high NPS) (hazard ratio: 7.058, 95% confidence interval: 5.174–9.629, p < 0.001) were found to be independent predictors of all‐cause mortality at long‐term follow‐up.ConclusionThe NPS as a malnutrition and inflammation marker in patients with severe aortic stenosis who underwent TAVR provides valuable information for all‐cause mortality under long‐term follow‐up.

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“…Karakoyun et al [ 21 ] found that NPS may be useful in predicting the risk of acute kidney injury in STEMI patients undergoing primary PCI. Ozkan et al [ 22 ] studied systemic immune-inflammation index (SII) and NPS for predicting coronary artery severity in patients undergoing coronary computed tomographic angiography. Unlike the other studies discussed, they reported that SII may have a net predictive effect while NPS may not.…”

Section: Discussionmentioning

confidence: 99%

Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients

Arugaslan

2023

Sisli Etfal

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Objectives Pulmonary arterial hypertension (PAH) is a specific form of pulmonary hypertension characterized by an increased mean pulmonary arterial pressure. Risk stratification is crucial in managing PAH, using various clinical, laboratory, and imaging parameters. The Naples prognostic score (NPS), incorporating nutritional and inflammatory markers, has demonstrated prognostic value in other conditions but not in PAH. The goal of this study was to appraise the importance of NPS as a prognostic indicator for patients with PAH. Methods This retrospective study involved 101 PAH patients. Echocardiographic, laboratory, and right heart catheterization data were collected. Statistical analyses compared variables between survivors and non-survivors, and multivariate logistic regression identified mortality risk factors. Results Among the 101 patients, 18 died within the follow-up period. The mortality group showed elevated levels of B-type natriuretic peptide (BNP) and significantly higher median NPS. Patients were categorized based on their NPS scores, revealing higher mortality in Group 2. Multivariate logistic regression identified age and BNP levels as independent predictors of mortality. The inclusion of NPS in the model further reinforced its association with mortality. Conclusion The study suggests that NPS is linked to poor outcomes in PAH patients. NPS, a straightforward and easily calculated score, holds the potential to predict the clinical trajectory of PAH, offering advantages for risk assessment in this population.

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Comparison of Systemic Immune-Inflammation Index and Naples Prognostic Score for Prediction Coronary Artery Severity Patients Undergoing Coronary Computed Tomographic Angiography

Cited by 11 publications

References 48 publications

The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation

The impact of the Naples Prognostic Score on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation

Clinical implication of the Naples prognostic score on transcatheter aortic valve replacement in patients with severe aortic stenosis

Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients

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