Comparison of T2 MSME and STIR methods in assessment of muscle emergency changes in patients with LGMD R2

Abstract

Introduction. The identification of early edematous changes using MRI and the assessment of the nature of their distribution among the muscles is important for the diagnosis of dysferlinopathy and the differentiation of hereditary muscular dystrophies from inflammatory myopathies. Purpose of the study: to assess the capabilities of STIR and T2 MSME methods in the diagnosis of early edematous changes in the muscles of patients with LGMDR2. Materials and methods: We examined 20 patients with clinical manifestations of dysferlinopathy, with an average age of 35 (24; 44) years. Magnetic resonance imaging of the muscles of the pelvic girdle and lower extremities was performed by 20 patients and a control group equivalent in sex and age.Results. The T2 MSME (ms) method based on the calculation of relaxation time has the highest diagnostic accuracy in detecting early edematous changes in muscles. The sensitivity of the STIR method was 56%, and the specificity was 100%. Conclusion. Dysferlinopathy is characterized by diffuse edema of the least affected muscles. STIR is optimal for differential diagnosis of myopathies characterized by edematous changes. Whereas, for the assessment of minimal edematous changes, T2 MSME is the most acceptable.