Comparison of tamsulosin with alfuzosin in the treatment of patients with lower urinary tract symptoms suggestive of bladder outlet obstruction (symptomatic benign prostatic hyperplasia)

Buzelin, Jean-Marie; Fonteyne, E.; Kontturi, M; Witjes, W.P.J.; St, A. KHAN for the European Tamsulosin

doi:10.1046/j.1464-410x.1997.00205.x

Cited by 147 publications

(85 citation statements)

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“…18,19 Additonally, tamsulosin related IFIS was observed even after 2 weeks of use as reported earlier. 20 For this reason, we believe that period of one month is sufficent to observe any possible changes of tamsulosin use on corneal biomechanics.…”

Section: Discussionmentioning

confidence: 98%

Effect of Tamsulosin on Corneal Biomechanical Features

Palamar¹,

Emre²,

Turna³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Tamsulosin (Flomax ® ) usage was reported to increase central corneal thickness (CCT). As CCT and ocular biomechanical parameters are closely related, this study was conducted to investigate the possible effects of tamsulosin on biomechanical parameters of cornea as measured with Reichert Ocular Response Analyser (ORA) in patients with benign prostate hyperplasia. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Besides full eye examination (best corrected visual acuity, intraocular pressure (IOP) measured with Goldmann applanation tonometry, CCT) ORA (corneal hysteresis, corneal resistance factor, corneal compensated IOP, Goldmann correlated IOP) measurements of 30 eyes of 15 male patients before and one month after tamsulosin therapy were performed. For comparisons paired t-test was used. R Re es su ul lt ts s: : Mean age in the study group was 61.50±6.10 (range 47-69) years. Pre-tamsulosin CCT was lower than post-tamsulosin values (pre-: 549.18±28.84 micrometers, post-: 556.77±24.86 micrometers; p=0.002). Although statistically insignificant corneal resistance factor after tamsulosin use was lower (pre-: 10.73±1.05 mmHg, post-: 9.45±1.51 mmHg; p=0.071). Measurements before and after tamsulosin treatment was not statistically different for any of the other parameters. C Co on nc cl lu us si io on n: : Tamsulosin seems not only to cause an increment on CCT, but also effect corneal resistance factor. The long term effects of tamsulosin on corneal biomechanical properties should further be investigated with larger group of patients. K Ke ey y W Wo or rd ds s: : Cornea; tamsulosin; eye Ö ÖZ ZE ET T A Am ma aç ç: : Tamsulosin (Flomax ® ) kullanımı sonrası merkezi kornea kalınlığında (MKK) artış olduğu bilinmektedir. Kornea kalınlığı ile korneanın biyomekanik özellikleri arasındaki yakın ilişki bulunduğundan, benign prostat hiperplazisi sebebiyle tamsulosin kullanan hastalarda korneada gelişebilecek muhtemel biyomekanik özellik değişikliklerinin Reicher Oküler Response Analiz cihaz (ORA) ile incelenmesi amacıyla bu çalışma planlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Tamsulosin kullanılmasından önce ve kullanımından 1 ay sonra 15 hastanın 30 gözünde tam oftalmolojik muayeneye (en iyi düzeltilmiş görme keskinliği, göz içi basınç ölçümü GİB) ilaveten MKK ölçümü ve ORA (korneal histerezis, korneal rezistans faktör, kornea kompanse GIB ve Goldmann korele GIB) ölçümleri yapılmış ve sonuçlar karşılaştırılmıştır. İstatistiksel analiz için eşleştirilmiş-t testi kullanılmıştır. B Bu ul lg gu ul la ar r: : Çalışma grubundaki hastaların ortalama yaşı 61,50±6,10 (range 47-69) yıl idi. Tamsulosin öncesi ve sonrasındaki MKK sırasıyla 549,18±28,84 ve 556,77±24,86 µm (p=0,002)idi. İn-celenen parametreler içerisinde hiçbir parametre için tedavi sonrasında anlamlı değişiklik izlenmemekle beraber yalnızca korneal rezistan faktör için , bir miktar azalma eğilimi olduğu izlenmiştir (pre-: 10,73±1,05 mmHg, post-:9,45±1,51 mmHg; p=0,071). S So on n...

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Section: Discussionmentioning

confidence: 98%

Effect of Tamsulosin on Corneal Biomechanical Features

Palamar¹,

Emre²,

Turna³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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“…In most hypertensive patients with a heart problem, alpha-1 blockers are not the first choice; rather, primarily beta-blockers, calcium channel blockers, and ACE inhibitors are used for BP control, and in these patients, for the treatment of BPH, those alpha-1 blockers with minimal effects on BP are more desirable. 22 Tamsulosin is a sulphonamide derivative and 12 times more selective to prostatic tissue than aorta. 23 Tamsulosin was not not developed as an anti-hypertensive, so it is not effective in BP control.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Different Alpha-blocker Combinations in Male Hypertensives with Refractory Lower Urinary Tract Symptoms

Lee

Kim²,

Cho

et al. 2011

Korean J Androl

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Results:The 269 patients (71.9%) were followed for at least 1 year (D group n=84, DT group n=115, and DF group n=70). The clinical parameters before and after initial 4 mg/day doxazosin were not different among the 3 groups. IPSS improvement after 3 months and maximal flow rate (Qmax) improvement after 3 and 12 months were significantly higher in the D and DT groups than the DF group (p＜0.05). Sitting systolic and diastolic BP of the D group decreased larger than those of the other 2 groups (p＜0.05). At least one of the AEs was reported by 29.0%, 19.3%, and 17.3% of patients in the D, DT, and DF groups, respectively. In particular, vasodilatory AEs of the D group (28.2%) were higher than those of other groups (p＜0.05), and sexual function AEs of the DF group (10.9%) were higher than those of other groups (p＜0.05).Conclusions: Doxazosin 4 mg plus tamsulosin 0.2 mg has comparable efficacy but less vasodilatory AEs than doxazosin 8 mg, and has superior efficacy to but comparable vasodilatory AEs to 4 mg doxazosin plus 5 mg finasteride in hypertensive male LUTS patients.

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“…7 A nationwide survey in Japan found autoimmune thyroiditis to be associated with primary biliary cirrhosis in 5.8% of cases. 8 Gordon and Isenberg suggest that there is an overlap between polmyalgia rheumatica (PMR) and GCA with autoimmune thyroid dysfunction. 9 Dent and Edwards, 10 in their series of 250 patients with autoimmune thyroiditis, noted PMR or GCA in 2.8% of patients.…”

Section: Commentmentioning

confidence: 99%

Ocular trauma caused by a loose slip-lock cannula during corneal hydration

Bradshaw

Shankar

Maini

et al. 2006

Eye

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the a1A-adrenergic receptors on the iris dilator muscle, resulting in disuse atrophy of the muscle; this in turn affects iris rigidity. 1 Controversy exists over the receptor subtypes present in the prostate and the precise mechanism of action of this type of agents. [2][3][4] Recent experience in our unit is in accord with Chang's report; 1 the majority of patients treated with tamsulosin undergoing cataract surgery seem to display the features of IFIS. We have noted no benefit from the temporary cessation of treatment preoperatively.The case we present here was, we believe, typical of IFIS. We are not aware of any previous reports of IFIS in patients treated with a1-adrenergic receptor blockers other than tamsulosin. It has been suggested that the a1A-subtype selectivity of tamsulosin might be accountable for the clinical manifestation of IFIS. 1 Alfuzosin, although not a1A-subtype-selective in vitro, 2,3,5-9 displays uroselective properties in vivo. [5][6][7] We postulate that the overall in vivo affinity of the a1-adrenergic receptor blockers towards a1A-subtype receptors might be responsible for IFIS rather than the in vitro a1A-selectivity per se. 2,7 We agree with previous authors that preoperative recognition of patients at risk of IFIS allows for appropriate surgical planning in anticipation of IFIS, with the intention of reducing the risk of preoperative complications. 1 It is our practice to insert, at commencement of surgery, disposable flexible translimbal iris retractors in a diamond configuration, as described by Oetting and Omphroy. 10 This seems to allow the operation to be completed safely and with little added difficulty.We believe that surgeons should anticipate IFIS in patients taking alfuzosin, in addition to those taking tamsulosin, and quite possibly in patients taking any of the uroselective a1-adrenergic receptor blockers. We are not aware of any reports of the nonuroselective a1-adrenergic receptor blockers causing IFIS. Comparison of tamsulosin with alfuzosin in the treatment of patients with lower urinary tract symptoms suggestive of bladder outlet obstruction (symptomatic benign prostatic hyperplasia). The European Tamsulosin Study Group. Br J Urol 1997; 80(4): 597-605. 9 Martin DJ, Lluel P, Guillot E, Coste A, Jammes D, Angel I.Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists.

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Comparison of tamsulosin with alfuzosin in the treatment of patients with lower urinary tract symptoms suggestive of bladder outlet obstruction (symptomatic benign prostatic hyperplasia)

Cited by 147 publications

References 4 publications

Effect of Tamsulosin on Corneal Biomechanical Features

Effect of Tamsulosin on Corneal Biomechanical Features

Comparison of Different Alpha-blocker Combinations in Male Hypertensives with Refractory Lower Urinary Tract Symptoms

Ocular trauma caused by a loose slip-lock cannula during corneal hydration

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