Comparison of Tanner staging of HIV-infected and uninfected girls at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria

Iloh, Ogochukwu N; Iloh, Kenechukwu K; Ubesie, Agozie C; Emodi, IJ; Ikefuna, AN; Ibeziako, Ngozi

doi:10.1515/jpem-2016-0356

Cited by 10 publications

(17 citation statements)

References 14 publications

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“…9,10,93 Whereas 70% of HIV-infected girls in the index study had attained puberty, Mbwile, [22] reported lower proportions in Tanzania where only 49% of HIV-infected females were found to have attained puberty. The proportion of HIV-infected females who had attained puberty in this study was also higher that reported by Iloh et al, [23]…”

Section: Discussionsupporting

confidence: 51%

Pubertal Development Pattern in HIV-Infected Girls in Port Harcourt, Southern Nigeria

Azubogu U. S.,

Ugwu R. O.,

Jaja T.

et al. 2023

JAMPS

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Background: Unidentified and untreated pubertal abnormalities in HIV-infected girls may result in adverse psychosocial consequences as well as a reduced final adult height. The aim of the study was to determine the pubertal development pattern in HIV-infected girls receiving care in two tertiary hospitals in Port Harcourt, Southern Nigeria. Materials and Methods: This was a comparative cross-sectional study involving 90 HIV-infected girls aged 10-18 years and 90 age, sex and socio-economic class matched non-HIV-infected girls. Results: The mean age of pubertal onset in HIV-infected girls was 11.57±1.05 which was significantly higher than the mean age of 10.78±0.69 seen in the non-HIV-infected group (ꭓ 2= 2.667, p=0.011). Sixty three (70%) of HIV-infected females had commenced puberty (Tanner stage 2 or above for breast development) compared to 83 (92.2%) of non-HIV-infected females. (χ2=16.277, p=0.003). Forty per cent (40%) of HIV-infected girls had attained menarche (40%) as against 52.2% in the comparison group but this difference was not statistically significant (χ2=2.705, p=0.100). There was a higher prevalence of pubertal delay in HIV-infected girls (6.7%) compared to non-HIV-infected girls (1.1%). Conclusion: The mean age of Pubertal onset was significantly later in HIV-infected girls compared to non-HIV-infected. This could have negative implications for psychosocial and reproductive health in HIV-infected girls.

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Section: Discussionsupporting

confidence: 51%

Pubertal Development Pattern in HIV-Infected Girls in Port Harcourt, Southern Nigeria

Azubogu U. S.,

Ugwu R. O.,

Jaja T.

et al. 2023

JAMPS

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“…Among PHIV youth in the US, delays in pubertal onset were observed for those with lower CD4 counts or higher viral load as compared to healthier PHIV youth [30]. In a small cross-sectional study conducted in Nigeria, a significantly lower percentage of HIV-infected girls had pubertal onset than an age-matched group of uninfected girls [32]. In longitudinal follow-up of HIV-infected ARROW trial participants in Africa, the observed mean ages at pubertal onset were 12.8 for boys and 11.7 for girls; the estimated mean age at menarche was 14.3 years [31].…”

Section: Pubertal Development In Hiv-infected Adolescentsmentioning

confidence: 99%

Growth and pubertal development in HIV-infected adolescents

Williams

Jesson

2018

Current Opinion in HIV and AIDS

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“…The physical growth and sexual maturation of perinatally-HIV infected male and female children have been well documented in studies conducted in developed and developing countries. In Nigeria, the few published studies that evaluated these outcomes were conducted in perinatally HIV-infected girls alone [ 20 , 23 ]. Thus, it is important to obtain data on similar outcomes among adolescent males seen in this clime.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas studies demonstrating growth and pubertal delay in male and female HIV-infected children have been conducted in the developed settings of Europe and the United States [14][15][16][17], similar studies in either of the sexes or both sexes have been conducted in sub-Saharan Africa as well [18][19][20][21][22]. In southeast Nigeria, a previous study in this locality focused on the female sex alone by investigating sexual maturation in perinatally HIVinfected girls aged 8-17 years [23]. The present study, however, aimed to determine the physical growth and sexual maturation of perinatally HIV-infected adolescent males and compare them with those of age-matched HIV-negative controls.…”

Section: Introductionmentioning

confidence: 99%

Physical growth and sexual maturation of perinatally HIV-infected adolescent males in a southeast Nigerian tertiary hospital: a comparative cross-sectional study

2022

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Background The advent of highly-active anti-retroviral therapy (HAART) has resulted in the survival of children with Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) into adolescence. Their prolonged survival has translated into co-morbidities like endocrine deficiencies which may manifest as growth and pubertal delay. This study aimed to determine the physical growth and sexual maturation of perinatally HIV-infected adolescent males and compare them with those of age-matched HIV-negative controls. Methods We conducted a comparative cross-sectional study of 104 perinatally HIV-infected males on HAART aged 10 to 19 years, and 104 age-matched HIV-negative males who served as controls. The subjects and controls were enrolled and assessed at a Nigerian tertiary hospital over six months. Anthropometric measurements such as weight, height, and BMI were obtained and Z scores for age were derived for weight, height, and BMI to determine physical growth using WHO AnthroPlus software. Sexual maturation was assessed using the method proposed by Marshall and Tanner. Data analysis and appropriate statistics were conducted with the Statistical Package for Social Sciences (SPSS) version 25 Chicago IL. A p-value < 0.05 was adopted as the level of statistical significance. Results The mean height, weight, and BMI Z scores of the subjects were all lower than those of the controls. The difference between the mean weight of the subjects (44.60 ± 13.32 kg) and the controls (49.97 ± 13.58 kg) was statistically significant (t = 2.88, p = 0.004). Similarly, the difference between the mean BMI Z-scores of the subjects (-0.96 ± 1.95) and the controls (-0.10 ± 0.86) was statistically significant (t = 4.10, p = < 0.001). The subjects showed a delay in pubic hair and testicular development for Stages 1, 2, and 3. Duration of HAART did not significantly affect the BMI of subjects who were in three groups: undernutrition, normal nutrition, and overnutrition (Kruskal-Wallis test, p = 0.30). Conclusion Perinatal HIV infection negatively affects physical growth and the onset of pubic-hair development (PH 2) despite the duration of HAART. We recommend that screening for weight deficit or pubertal delay should form part of the management protocol for HIV-infected male children on HAART.

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Comparison of Tanner staging of HIV-infected and uninfected girls at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria

Abstract: Perinatal HIV infection affected the onset of pubic hair and breast development but did not significantly affect the attainment of sexual maturation.

Cited by 10 publications

References 14 publications

Pubertal Development Pattern in HIV-Infected Girls in Port Harcourt, Southern Nigeria

Pubertal Development Pattern in HIV-Infected Girls in Port Harcourt, Southern Nigeria

Growth and pubertal development in HIV-infected adolescents

Physical growth and sexual maturation of perinatally HIV-infected adolescent males in a southeast Nigerian tertiary hospital: a comparative cross-sectional study

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