Comparison of the ${^{1}{\rm H}}$ NMR Relaxation Enhancement Produced by Bacterial Magnetosomes and Synthetic Iron Oxide Nanoparticles for Potential Use as MR Molecular Probes

Hu, Li; Zhang, F; Wang, Z; You, Xiao Fei; Nie, Libo; Wang, H X; Song, Tao; Yang, Wen

doi:10.1109/tasc.2010.2041218

Cited by 14 publications

(11 citation statements)

References 17 publications

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“… 366 , 367 Additionally, the biosynthesis of magnetosomes from MTBs is highly controlled and results in particles with uniform size, shape, dispersion, and even magnetization, whereas magnetic NPs that are synthesized by chemical precipitation are often superparamagnetic and nonuniform with respect to the aforementioned parameters. 368 …”

Section: Biological Methods To Improve Nm Delivery To Tumorsmentioning

confidence: 99%

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

et al. 2021

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Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a decade. Classically, scientists have tried to improve NM delivery by employing passive or active targeting strategies, making use of the so-called enhanced permeability and retention (EPR) effect. This phenomenon is made possible due to the leaky tumor vasculature through which NMs can leave the bloodstream, traverse through the gaps in the endothelial lining of the vessels, and enter the tumor. Recent studies have shown that despite many efforts to employ the EPR effect, this process remains very poor. Furthermore, the role of the EPR effect has been called into question, where it has been suggested that NMs enter the tumor via active mechanisms and not through the endothelial gaps. In this review, we provide a short overview of the EPR and mechanisms to enhance it, after which we focus on alternative delivery strategies that do not solely rely on EPR in itself but can offer interesting pharmacological, physical, and biological solutions for enhanced delivery. We discuss the strengths and shortcomings of these different strategies and suggest combinatorial approaches as the ideal path forward.

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Section: Biological Methods To Improve Nm Delivery To Tumorsmentioning

confidence: 99%

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

et al. 2021

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“…Such high values of r 2 can be reached with the magnetosomes. Indeed, it has been shown that both magnetosomes enclosed in a gel and ferrimagnetic nanoparticles different from ferridex and with similar properties than the magnetosomes possess values of r 2 as high as 1175 and 324 mM s −1 , respectively (Hu et al, 2010 ; Lee et al, 2011 ). These two values are larger than the value of r 2 ~ 133 mM s −1 found for chemically synthesized nanoparticles ferridex, which are currently approved and tested in the clinic as contrast agents for MRI application (Lee et al, 2011 ).…”

Section: Applications Of Magnetosomes In Mri Magnetic Hyperthermia mentioning

confidence: 99%

Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine

Alphandéry

2014

Front. Bioeng. Biotechnol.

105

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Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth’s magnetic field. This compass helps the bacteria to find the optimum conditions for their growth and survival. Here, we review several medical applications of magnetosomes, such as those in magnetic resonance imaging (MRI), magnetic hyperthermia, and drug delivery. Different methods that can be used to prepare the magnetosomes for these applications are described. The toxicity and biodistribution results that have been published are summarized. They show that the magnetosomes can safely be used provided that they are prepared in specific conditions. The advantageous properties of the magnetosomes compared with those of chemically synthesized nanoparticles of similar composition are also highlighted.

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“…Therefore, only a limited number of MTB can be isolated as a pure culture, hence due to the low cell densities, the sufficient numbers of magnetosomes cannot be purified which further hampers industrial applications. The emerging opportunities relating to MTB are high-data storage, MRI, treating disease by a mannose-binding lectin, DNA discrimination analysis, drug delivery, they act as carriers for enzymes, nucleic acids, antibodies, biosensors and waste-water treatment [13,28].…”

Section: Discussionmentioning

confidence: 99%

Detection and Characterization of Magnetosome Chains In Magnetotactic Bacteria

Bharadhwaj¹,

Vijay²,

Raghunath³

2020

Preprint

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Aim: Magnetotactic bacteria are gram-negative, prokaryotic organisms which align themselves according to the Earths geomagnetic field. They contain organelles called magnetosomes which produce nano-magnetites by the mechanism of biomineralization. These nano-magnetites are arranged in the form of well-ordered chain called magnetosome chain, which are held together by intermolecular forces . The growth of these bacteria is stringent to specific oxygen gradient regions, where there is oxic-anoxic transition zone. In this paper, we report the cultivation and characterisation of magnetotactic bacteria that was accomplished under laboratory conditions and scanning electron microscope respectively. Methodology: Bacterial soil samples were collected and cultivated under laboratory conditions using a precise and cost-effective media formulation using coffee bean extract and ferric chloride, which were to provide sufficient iron under the influence of external magnetic field. Experiments were conducted using media, deficient with ferric chloride and coffee bean solution, as control. Pour plate method was carried out for the growth of bacteria under the influence of external magnetic field provided on one-end of the petri-plate. Result: We observed the growth of the cultivated bacteria in the proximity of the magnetic field only in the presence of iron in media. This emphasises that the media formulated was appropriate for the growth of bacteria under laboratory conditions. Scanning electron microscope analysis confirmed the presence of magnetosome chains in magnetotactic bacteria. Interpretation: In this research, the bacteria were able to sustain in artificial oxygen-transition zones provided in the laboratory. The coffee bean solution contained quinic acid and succinic acid, which along with ferric chloride provided iron in the form of ferric quinate, and succinic acid which are the major sources of growth for the bacteria. Even though magnetosome research has shown promising advances, one of major limitations in its commercialization is its difficulty in cultivation under laboratory conditions.

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Comparison of the ${^{1}{\rm H}}$ NMR Relaxation Enhancement Produced by Bacterial Magnetosomes and Synthetic Iron Oxide Nanoparticles for Potential Use as MR Molecular Probes

Cited by 14 publications

References 17 publications

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Applications of Magnetosomes Synthesized by Magnetotactic Bacteria in Medicine

Detection and Characterization of Magnetosome Chains In Magnetotactic Bacteria

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