Comparison of the acute erythropoietic capacities of erythropoietin and U-74389G in terms of hemoglobin levels

Tsompos, Constantinos; Panoulis, Constantinos; Toutouzas, Konstantinos; Triantafyllou, Aggeliki; Zografos, George; Papalois, A.

doi:10.5045/br.2017.52.4.334

Cited by 2 publications

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References 9 publications

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“…A U-74389G / erythropoietin efficacies ratios meta-analysis on 4 hematologic variables (3 variables with balancing efficacies and 1 variable with opposite efficacies)[21].…”

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confidence: 99%

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2017

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This study calculated the opposite capacities of 2 drugs: the erythropoietin (Epo) and the antioxidant drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the platelet crit (PCT) levels alterations, after the respective drug usage in an induced hypoxia reoxygenation animal experiment. Materials and methods:The 2 main experimental endpoints at which the PCT levels (PCTl) were evaluated were the 60th reoxygenation min (for the groups A, C and E) and the 120th reoxygenation min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after U-74389G administration. Results:The first preliminary study of Epo non significantly decreased the PCTl by 6.88% ± 3.69% (p-value=0.0615). Also, the second preliminary study of U-74389G non-significantly increased the PCTl by 6.73% ± 37.45% (p-value=0.0712). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has opposite acute effect than Epo (p-value=0.0000). Conclusion:The anti-oxidant capacities of U-74389G enhance the acute increasing properties on PCTl than epo (p-value=0.0000).

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“…A U-74389G / erythropoietin efficacies ratios meta-analysis on 4 hematologic variables (3 variables with balancing efficacies and 1 variable with opposite efficacies)[21].…”

mentioning

confidence: 99%

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2017

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Comparison of the excretory capacities of erythropoietin and U-74389G concerning serum creatinine levels

Tsompos¹,

Panoulis

Toutouzas³

et al. 2018

Urol Colomb

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Introduction This study compared the excretory effects, the erythropoietin (Epo) and antioxidant drug U-74389G exert on serum creatinine levels through kidneys. 2 preliminary studies were used for this purpose including respectively one drug used in a renal ischemia–reperfusion (IR) protocol of an animal model. The preliminary studies are part of the present work. The subjects were pretreated in preliminary studies but the results of the same subjects were simply compared in the current work.Materials and methods The serum creatinine levels were evaluated at the 60th reperfusion min (for groups A, C and E) and at the 120th reperfusion min (for groups B, D and F) after IR in the 60 rats. Groups A and B received no drugs, rats from groups C and D were administered with Epo, whereas rats from groups E and F were administered with U-74389G.Results The first preliminary study recommended a non-significant excretory effect of Epo (p-value = 0.4430 > 0.05) than placebo for serum creatinine levels. The second preliminary study proved a very significant excretory effect of U-74389G (p-value = 0.0005 < 0.05) than placebo for serum creatinine levels. These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that U-74389G has at least 5-fold significant excretory action (p-value = 0.0000 < 0.05) than Epo for serum creatinine levels.Conclusions The U-74389G presents surprising effective excretory potencies for serum creatinine levels maybe of great importance in hemodialysis patients.

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Comparison of the acute erythropoietic capacities of erythropoietin and U-74389G in terms of hemoglobin levels

Cited by 2 publications

References 9 publications

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Comparison of the excretory capacities of erythropoietin and U-74389G concerning serum creatinine levels

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