Comparison of the Analgesic Effects of a Fixed-Dose Combination of??Orphenadrine and Diclofenac (Neodolpasse??) with its Single Active??Ingredients Diclofenac and Orphenadrine

Schaffler, K.; Reitmeir, Peter; Gschanes, Andrea; Eggenreich, U.

doi:10.2165/00126839-200506040-00001

Cited by 34 publications

(29 citation statements)

References 22 publications

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“…Intravenous orphenadrine 30 mg has been investigated alone and in combination with diclofenac . Schaffler et al .…”

Section: Miscellaneoussupporting

confidence: 67%

“…The combination (as well as orphenadrine by itself) decreased the EP amplitude to laser stimulation (P2 at approximately 260 ms), whereas the decrease in EP amplitude induced by diclofenac 75 mg failed to reach a significant level. No subjective pain measures were reported in the study .…”

Section: Non‐steroidal Anti‐inflammatory Drugs and Paracetamolmentioning

confidence: 99%

“…compared a combination of orphenadrine 30 mg and diclofenac 75 mg with each of the single active ingredients. The combination (as well as orphenadrine by itself) decreased the EP amplitude (P2 at approximately 260 ms) to laser stimulation . Correspondingly the earlier study found decreased amplitudes of the late peaks (N1, P2) .…”

Section: Miscellaneousmentioning

confidence: 99%

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Electroencephalography and analgesics

Malver

Brokjær

Staahl

et al. 2013

Brit J Clinical Pharma

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To assess centrally mediated analgesic mechanisms in clinical trials with pain patients, objective standardized methods such as electroencephalography (EEG) has many advantages. The aim of this review is to provide the reader with an overview of present findings in analgesics assessed with spontaneous EEG and evoked brain potentials (EPs) in humans. Furthermore, EEG methodologies will be discussed with respect to translation from animals to humans and future perspectives in predicting analgesic efficacy. We searched PubMed with MeSH terms 'analgesics' , 'electroencephalography' and 'evoked potentials' for relevant articles. Combined with a search in their reference lists 15 articles on spontaneous EEG and 55 papers on EPs were identified. Overall, opioids produced increased activity in the delta band in the spontaneous EEG, but increases in higher frequency bands were also seen. The EP amplitudes decreased in the majority of studies. Anticonvulsants used as analgesics showed inconsistent results. The N-methyl-D-aspartate receptor antagonist ketamine showed an increase in the theta band in spontaneous EEG and decreases in EP amplitudes. Tricyclic antidepressants increased the activity in the delta, theta and beta bands in the spontaneous EEG while EPs were inconsistently affected. Weak analgesics were mainly investigated with EPs and a decrease in amplitudes was generally observed. This review reveals that both spontaneous EEG and EPs are widely used as biomarkers for analgesic drug effects. Methodological differences are common and a more uniform approach will further enhance the value of such biomarkers for drug development and prediction of treatment response in individual patients.

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“…Intravenous orphenadrine 30 mg has been investigated alone and in combination with diclofenac . Schaffler et al .…”

Section: Miscellaneoussupporting

confidence: 67%

Section: Non‐steroidal Anti‐inflammatory Drugs and Paracetamolmentioning

confidence: 99%

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Electroencephalography and analgesics

Malver

Brokjær

Staahl

et al. 2013

Brit J Clinical Pharma

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“…This effect is comparable or even superior to previous findings [4,[18][19][20], a phenomenon which might be at least partially attributed to the use of the fixed-dose combination of diclofenac and orphenadrine. Orphenadrine is a centrally acting analgesic which blocks the NMDA and the H1-receptor causing faster onset of action compared to diclofenac alone [21]. In addition it has mild sedative effects and reduces pathologically increased muscle tension.…”

Section: Discussionmentioning

confidence: 99%

Opiate sparing effect of fixed combination of diclophenac and orphenadrine after unilateral total hip arthroplasty: A double-blind, randomized, placebo-controlled, multi-centre clinical trial

Gombotz

Lochner

Sigl

et al. 2010

Wien Med Wochenschr

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Multimodal pain management combines analgesics to improve analgesia and reduce side effects. This study investigates the fixed combination of diclophenac and orphenadrin (Neodolpasse(®) Infusion Solution) in patients after unilateral total hip arthroplasty (THA). This prospective, randomized, double-blind, placebo-controlled, multi-centre clinical study enrolled 120 patients receiving patient-controlled analgesia (PCA). Isotonic saline was infused as placebo. The primary efficacy goal was defined as reduction of PCA analgesics used over the first 24 h post-surgery. The study used a three-stage group sequential test design with two interim analyses. Analgesia was monitored by visual analogue scale and verbal rating. Infusion of the Neodolpasse(®) Infusion Solution resulted in a significant reduction in the PCA analgesic requirements by approximately 30% (38.7 ± 21.3 mg vs. 55.9 ± 31.1 mg; p = 0.0004) while maintaining adequate analgesia and patient safety. This study demonstrates that Neodolpasse(®) Infusion Solution significantly reduces PCA analgesic requirements without compromising analgesic effectiveness and safety in THA patients.

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“…DFS has been reported to be more potent and less toxic than other NSAIDs such as aspirin or ibuprofen [13]. Diclofenac (sodium o-2,6-dichloroanilino-phenyl acetate, DCF) has been reported to be an effective antirheumatic, anti-inflammatory, analgesic and antipyretic NSAID [14,15]. Although DCF has been used in the long-term treatment of arthritis, some residues of DCF have been linked to renal disease [16].…”

Section: Introductionmentioning

confidence: 99%

Determination of Nonsteroidal Anti‐inflammatory Drugs in Serum by Microchip Capillary Electrophoresis with Electrochemical Detection

Ding

Garcı́a

2006

Electroanalysis

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A simple and rapid method has been developed for the analysis of four nonsteroidal anti-inflammatory drugs (NSAIDs) in serum using microchip capillary electrophoresis with pulsed amperometric detection. The selected NSAIDs (salicylic acid, acetaminophen, diflunisal, and diclofenac) are among the most commonly used drugs to treat fever, inflammation, and pain. Used above the therapeutic levels, these drugs can cause a wide variety of adverse effects and their fast analysis could have a significant impact in treatment and recovery of the patients. Several conditions, including separation potential, pH, and concentration of the electrolyte solution were studied to optimize the separation and detection. In this study, salicylic acid, acetaminophen, diflunisal, and diclofenac were separated in less than 2 minutes using a 5 mM borate buffer at pH 11.5 and a separation potential of þ 1200 V. Linear relationships were obtained between the concentration and peak current in the 0.5 -15.3 mg/mL range and detection limits around 0.26 mg/mL. After 30 consecutive injections, the stability of both the response and migration time of the analytes showed relative related deviations of less than 4.6% and 1.0%, respectively. The potential of this method was verified by spiking a bovine serum sample with the four NSAIDs and analyzing the recovery ratio.

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Comparison of the Analgesic Effects of a Fixed-Dose Combination of??Orphenadrine and Diclofenac (Neodolpasse??) with its Single Active??Ingredients Diclofenac and Orphenadrine

Cited by 34 publications

References 22 publications

Electroencephalography and analgesics

Electroencephalography and analgesics

Opiate sparing effect of fixed combination of diclophenac and orphenadrine after unilateral total hip arthroplasty: A double-blind, randomized, placebo-controlled, multi-centre clinical trial

Determination of Nonsteroidal Anti‐inflammatory Drugs in Serum by Microchip Capillary Electrophoresis with Electrochemical Detection

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