Comparison of the Analgesic Effects of Dimethyl Sulfoxide and Morphine*

Haigler, Henry J.; Spring, Denise D.

doi:10.1111/j.1749-6632.1983.tb47281.x

Cited by 35 publications

(15 citation statements)

References 13 publications

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“…It has, also, a wide spectrum of pharmacological activity of itself (David 1972;Haigler 1983;Brayton 1986) and has received renewed interest in the last few years as a therapeutic agent, particularly in North America. However, in view of reports linking DMSO to cataracts in laboratory animals (Rubin & Barnett 1967), and debate about its carcinogenic potential, some have cautioned its clinical use until adequate safety data become available (Savastano 1984).…”

mentioning

confidence: 99%

Effects of dimethyl sulphoxide (DMSO) on aggregation of human blood platelets

Lehuu

Curtis-Prior

1987

Journal of Pharmacy and Pharmacology

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The effects were examined of the universal solvent dimethyl sulphoxide (DMSO) on human platelet aggregatory activity, in-vitro, of the endogenous mediators ADP, adrenaline, arachidonic acid, collagen and PAF-acether which are believed to play important roles in cardiovascular diseases in man. DMSO inhibited aggregation induced by all of the mediators in the order ADP greater than adrenaline = arachidonic acid = PAF-acether greater than collagen. Since DMSO is widely used as a solvent for drug substances, an awareness of its intrinsic activity in any such evaluations is essential.

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confidence: 99%

Effects of dimethyl sulphoxide (DMSO) on aggregation of human blood platelets

Lehuu

Curtis-Prior

1987

Journal of Pharmacy and Pharmacology

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“…It is widely employed in cell biology 4 as an effective penetration enhancer, 5 cryoprotectant, 6 and cell fusogen 7 and has been promoted clinically as a local analgesic 8 and a protective agent against ischemic injury. 9 Recent computational studies 10,11 suggest that the experimentally observed ability of DMSO to enhance the permeability of cell membranes is most likely coupled to DMSO-induced water pores in membranes.…”

Section: Introductionmentioning

confidence: 99%

Ion Transport through Chemically Induced Pores in Protein-Free Phospholipid Membranes

Gurtovenko

Anwar

2007

J. Phys. Chem. B

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We address the possibility of being able to induce the trafficking of salt ions and other solutes across cell membranes without the use of specific protein-based transporters or pumps. On the basis of realistic atomicscale molecular dynamics simulations, we demonstrate that transmembrane ionic leakage can be initiated by chemical means, in this instance through addition of dimethyl sulfoxide (DMSO), a solvent widely used in cell biology. Our results provide compelling evidence that the small amphiphilic solute DMSO is able to induce transient defects (water pores) in membranes and to promote a subsequent diffusive pore-mediated transport of salt ions. The findings are consistent with available experimental data and offer a molecularlevel explanation for the experimentally observed activities of DMSO solvent as an efficient penetration enhancer and a cryoprotectant, as well as an analgesic. Our findings suggest that transient pore formation by chemical means could emerge as an important general principle for therapeutics.

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“…The detrimental bioactivities above outlined have to The lack of DMSO effect on thermal pain perception was a rather unexpected finding in light of its antinociceptive properties reported in some studies. DMSO has an antipain effect longer than morphine, although seemingly unrelated to opioid transmission as it is not contingent on naloxone antagonism (Haigler 1983;Haigler and Spring 1981). It also displays skin-related antinociception in topical preparations in conjuction with morphine or lidocaine (Kumar et al 2011;Kolesnikov et al 2000), which goes beyond that presented by either archetype analgesic agent.…”

Section: Resultsmentioning

confidence: 97%

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

Takeda

Pokorski

Okada

2016

Advances in Experimental Medicine and Biology

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Dimethyl sulfoxide (DMSO) is commonly used as a solvent for hydrophobic substances, but the compound's innate bioactivity is an area of limited understanding. In this investigation we seek to determine the analgesic potential of DMSO. We addressed the issue by assessing the perception of thermal pain stimulus, using a 55 °C hotplate design, in conscious mice. The latency of withdrawal behaviors over a range of incremental accumulative intraperitoneal DMSO doses (0.5-15.5 g/kg) in the same mouse was taken as a measure of thermal endurance. The findings were that the latency, on average, amounted to 15-30 s and it differed inappreciably between the sequential DMSO conditions. Nor was it different from the pre-DMSO control conditions. Thus, DMSO did not influence the cutaneous thermal pain perception. The findings do not lend support to those literature reports that point to the plausible antinociceptive potential of DMSO as one of a plethora of its innate bioactivities. However, the findings concern the mouse's footpad nociceptors which have specific morphology and stimulus transduction pathways, which cannot exclude DMSO's antinociceptive influence on other types of pain or in other types of skin. Complex and as yet unresolved neural mechanisms of perception of cutaneous noxious heat stimulus should be further explored with alternative experimental designs.

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Comparison of the Analgesic Effects of Dimethyl Sulfoxide and Morphine*

Cited by 35 publications

References 13 publications

Effects of dimethyl sulphoxide (DMSO) on aggregation of human blood platelets

Effects of dimethyl sulphoxide (DMSO) on aggregation of human blood platelets

Ion Transport through Chemically Induced Pores in Protein-Free Phospholipid Membranes

Thermal Sensitivity and Dimethyl Sulfoxide (DMSO)

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