Comparison of the anorexigenic activity of CRF family peptides

Tanaka, Chie; Asakawa, Akihiro; Ushikai, Miharu; Sakoguchi, Takeo; Amitani, Haruka; Terashi, Mutsumi; Cheng, Kai‐Chun; Chaolu, Huhe; Nakamura, Norifumi; Inui, Akio

doi:10.1016/j.bbrc.2009.10.069

Cited by 47 publications

(51 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Effects Of Crf Family Peptides On the Regulation Of Food Intmentioning

confidence: 67%

“…Food intake and body weight gain are inhibited by long-term administration (43,56,57). The feeding-inhibitory action of IP administered CRF is similar to that of UCN2: more potent than UCN3 but weaker than UCN1 (57). Most previous studies on the action of CRF on feeding behavior have demonstrated that CRF inhibits food intake when administered ICV to fasting rats or mice (6,(58)(59)(60)(61).…”

Section: Effects Of Crf Family Peptides On the Regulation Of Food Intmentioning

confidence: 75%

See 1 more Smart Citation

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

Nakayama

Suzuki

et al. 2011

BioMolecular Concepts

Self Cite

View full text Add to dashboard Cite

Corticotropin-releasing factor (CRF) and the urocortins (UCN1, UCN2, and UCN3) belong to the CRF family of peptides and are the major regulators of the adaptive response to internal and external stresses. The actions of CRF and UCNs are mediated through two receptor subtypes: CRF receptor 1 (CRFR1) and CRFR2. Their physiological roles, among other functions, include the regulation of food intake and anxiety-like behavior. In this review, we describe the progress that has been made towards understanding how anxiety-and depression-like behavior and food intake are regulated by CRF, UCN1, UCN2, and UCN3.

show abstract

Section: Effects Of Crf Family Peptides On the Regulation Of Food Intmentioning

confidence: 67%

Section: Effects Of Crf Family Peptides On the Regulation Of Food Intmentioning

confidence: 75%

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

Nakayama

Suzuki

et al. 2011

BioMolecular Concepts

Self Cite

View full text Add to dashboard Cite

show abstract

“…Peripheral administration of UCN or CRF induces inhibition of gastric emptying and a reduction in food intake (22,45). The effects induced by peripheral administration of UCN or CRF are inhibited by peripheral but not by central administration of CRF receptor antagonists (18,53).…”

Section: Discussionmentioning

confidence: 99%

Urocortin 1 reduces food intake and ghrelin secretion via CRF₂ receptors

Yakabi

Noguchi

Ohno

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

it is known that urocortin 1 (UCN) acts on both corticotropinreleasing factor receptors (CRF 1 and CRF2), the mechanisms underlying UCN-induced anorexia remain unclear. In contrast, ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, stimulates food intake. In the present study, we examined the effects of CRF 1 and CRF2 receptor antagonists (CRF1a and CRF2a) on ghrelin secretion and synthesis, c-fos mRNA expression in the caudal brain stem, and food intake following intracerebroventricular administration of UCN. Eight-week-old, male Sprague-Dawley rats were used after 24-h food deprivation. Acylated and des-acylated ghrelin levels were measured by enzyme-linked immunosorbent assay. The mRNA expressions of preproghrelin and c-fos were measured by real-time RT-PCR. The present study provided the following important insights into the mechanisms underlying the anorectic effects of UCN: 1) UCN increased acylated and des-acylated ghrelin levels in the gastric body and decreased their levels in the plasma; 2) UCN decreased preproghrelin mRNA levels in the gastric body; 3) UCN-induced reduction of plasma ghrelin and food intake were restored by CRF 2a but not CRF1a; 4) UCN-induced increase of c-fos mRNA levels in the caudal brain stem containing the nucleus of the solitary tract (NTS) was inhibited by CRF 2a; and 5) UCN-induced reduction of food intake was restored by exogenous ghrelin and rikkunshito, an endogenous ghrelin secretion regulator. Thus, UCN increases neuronal activation in the caudal brain stem containing NTS via CRF 2 receptors, which may be related to UCN-induced inhibition of both ghrelin secretion and food intake.corticotropin-releasing factor receptors; dorsal vagal complex; rikkunshito; digestive system hormone; anorexia STRESSFUL LIFE EVENTS have been associated with the onset or symptom exacerbation of several functional gastrointestinal disorders including functional dyspepsia and irritable bowel syndrome (24). Corticotropin-releasing factor (CRF) is a key mediator in the central nervous system and is secreted as an adaptive response to stress. In rodents, central CRF administration induces stress-like behaviors, including increased depression, decreased rearing activity, and suppression of food intake (5, 50). Urocortin 1 (UCN), a member of the mammalian CRF family, bears 45% sequence identity to CRF and acts as an endogenous ligand for CRF receptors (49). Although CRF and UCN mediate their actions through the activation of CRF 1 and CRF 2 receptors, CRF and UCN display different binding affinities for these receptors. CRF preferentially binds to CRF 1 receptors, whereas UCN shows high affinity for both receptors; we therefore believe that UCN is useful for examining the actions of both CRF 1 and CRF 2 receptors. Central UCN administration suppresses feeding in rats and mice, and the suppression was shown to be at least partly CRF 2 mediated in studies that used selective antagonists (7) or antisense oligonucleotides (38). In addition, the initial effect of food intake in...

show abstract

“…We previously reported that peripherally administered Ucn1 was more potent than CRF in the regulation of anorexigenic activity when the two were administered at the same doses (17). Ohata and Shibasaki found that intracerebroventricular administration of Ucn3 and Ucn2 decreased food intake in rats fed ad libitum (15).…”

Section: Discussionmentioning

confidence: 99%

Effects of peripherally administered urocortin 3 on feeding behavior and gastric emptying in mice

Terashi

Asakawa

Cheng

et al. 2011

Experimental and Therapeutic Medicine

Self Cite

View full text Add to dashboard Cite

Abstract. Human and mouse urocortin 3 (Ucn3) were first identified in 2001. Ucn3 binds selectively to corticotropinreleasing factor receptor type 2 (CRF-R2). Previous studies have shown that centrally administered Ucn3 decreases food intake in rats. However, the role of Ucn3 in the regulation of gut motility remains to be determined. In the present study, we investigated the effects of peripherally administered Ucn3 on food intake and gastric emptying in mice. After intraperitoneal (i.p.) administration of Ucn3, food intake was measured in the light and dark phases, and the rate of gastric emptying was determined. We found that i.p. administration of Ucn3 significantly inhibited feeding behavior in mice, and significantly delayed gastric emptying 1-2 h after administration in a dose-dependent manner. These results suggest that Ucn3 contributes to the modulation of feeding behavior and gut motility. Thus, Ucn3 and CRF-R2 may be involved in the pathogenesis of functional gastrointestinal and eating disorders.

show abstract

Comparison of the anorexigenic activity of CRF family peptides

Cited by 47 publications

References 29 publications

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

Urocortin 1 reduces food intake and ghrelin secretion via CRF₂ receptors

Effects of peripherally administered urocortin 3 on feeding behavior and gastric emptying in mice

Contact Info

Product

Resources

About

Comparison of the anorexigenic activity of CRF family peptides

Cited by 47 publications

References 29 publications

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

Urocortin 1 reduces food intake and ghrelin secretion via CRF2 receptors

Effects of peripherally administered urocortin 3 on feeding behavior and gastric emptying in mice

Contact Info

Product

Resources

About

Urocortin 1 reduces food intake and ghrelin secretion via CRF₂ receptors