Comparison of the Anti-Herpes Simplex Virus Activities of Propolis and 3-Methyl-but-2-enyl Caffeate

Amoros, M.; Lurton, E.; Boustie, J.; Girre, L.; Sauvager, F.; Cormier, Michel

doi:10.1021/np50107a013

Cited by 153 publications

(131 citation statements)

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“…Candida albicans, C. tropicalis, Tenia versicolor and Aspergillus flavus were also inhibited by propolis. Moreover propolis inhibited viruses including avian influenza virus and herpes simplex virus type 1 (Amoros et al, 1994;Kujumgiev et al, 1999;Uzel et al, DOI:http://dx.doi.org/10.7314/APJCP.2013.14.11.6991 Antioxidant and Anti-cancer The extraction of propolis using maceration and sonication affected biological properties of propolis especially antioxidant activity, antiproliferative activity, total phenolic and flavonoid compound contents. These two methods gave the different active compounds.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Khacha-ananda¹,

Tragoolpua²,

Chantawannakul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Khacha-ananda¹,

Tragoolpua²,

Chantawannakul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The inhibition mechanism of virus by crude algal extracts was studied using two methods: Viral replication according to Amoros et al (1994) and viral adsorption according to Zhang et al (1995).…”

Section: Mode Of Actionmentioning

confidence: 99%

Salt stress enhancement of antioxidant and antiviral efficiency of Spirulina platensis

Shalaby¹,

Shanab²,

Singh³

2010

J. Med. Plants Res.

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Cultivation of Spirulina platensis under salt stress conditions (0.02 M as control), 0.04 and 0.08 M NaCl led to a remarkable alteration of algal metabolism as well as an enhancement or induction of biologically active compounds. Concerning algal growth, salt stress caused a decrease in dry weight, chlorophyll a content as well as certain xanthophylls (neoxanthin and violaxanthin) while β-carotene production was stimulated especially at higher salt concentrations. Biochemical analysis of salt stressed algal revealed that lipid content was slightly increased together with certain saturated and unsaturated fatty acids especially the polyunsaturated ones (γ-inolenic acid, omega 3 fatty acid). Electrophoretic analysis of soluble protein pointed out that certain high molecular weight protein bands were not detected comparing with the protein marker. Five new protein bands of molecular weights 190, 158, 113, 77 and 28 KDa were recorded, in addition to an increase in the intensity of 6 already existing bands. Phosphate buffer and water extracts of the algal exhibited antiviral activities against both Hepatitis-A-virus-type-MBB (HAV-MBB strain, RNA virus) and Herpes simplex-virus-type-1 (HSV-1, DNA virus). Water extracts were found to be more effective than phosphate buffer extracts in inducing antiviral activities (98%) especially against HSV-1 virus. The same water extract of the salt stressed algal demonstrated higher anticoagulating activity compared with those of heparin and the positive control measured by clotting time assay. Antioxidant activity of the algal successive extracts against 2, 2 diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (ethylbenzthiazoline-6-sulfonic acid) radical methods revealed moderate antioxidant activity of the non-polar algal extracts (petroleum ether) which were doubled with increasing extract concentration. The lowest activity was recorded by the partially polar (ethyl acetate) algal extract of both concentrations at all salinity levels. While the polar extracts (ethanol and water) showed higher antioxidant activities which were doubled with increasing extract concentration. Ethanolic algal extract (100 µg/ ml at 0.08 M NaCl) exhibited the highest antioxidant activity compared with those of the synthetic antioxidant butylated hydroxy anisol as standard (85.0, 89.9 and 86.0, 91.8% respectively).Key words: Spirulina platensis, antioxidant-antivirus, biochemical studies, salt stress. INTRODUCTIONMany cyanobacteria and micro algae were considered as a natural source of various biologically and pharmacologically active compounds with structurally complex molecules which are difficult or impossible to be *Corresponding author. E-mail: dremad2009@yahoo.com.produced by chemical synthesis (Smith and Doan, 1999). Genus Spirulina has gained an importance and international demand for its high phytonutrients value and pigments which have applications in healthy foods, animal feed, therapeutics and diagnostics (Becker, 1994;Vonshak and Tomaselli, 2000). Spirulina has been used as food and nutritional ...

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“…Propolis has been used in folk medicine for many years, especially in Europe and Japan, due to the variety of its therapeutic activities (Chen et al, 2009) including antibacterial (Kujumgiev et al, 1999), antifungal (Valdés et al, 1987), antiviral (Amoros et al, 1994), anticancer (Matsuno, 1995) (Kimoto et al, 2001), immunomodulation (Dimov et al, 1992) and antiinflammatory activities (Dobrowolski et al, 1991), among others. These activities are associated with the phenolic constituents, especially flavonoids and phenolic acids (Funari and Ferro, 2006).…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

Paviani

Saito

Dariva

et al. 2012

Braz. J. Chem. Eng.

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-Three types of propolis extract were prepared and analyzed with respect to their global extraction yields and with respect to the concentration of the following markers: 3,5-diprenyl-4-hydroxycinnamic acid; 3-prenyl-4-hydroxycinnamic acid; 4-hydroxycinnamic acid and 4-methoxy-3,5,7-trihydroxyflavone. The extract EEP (ethanolic extract of propolis) was obtained by the conventional method from raw propolis using ethanol as solvent. The extracts (SFE) were obtained by supercritical solvent extraction from the raw propolis using supercritical carbon dioxide (sc-CO 2 ), with and without the addition of ethanol as a co-solvent. The fractionated supercritical extracts (FSCE) were obtained by fractionation (extract and raffinate) of the dry EEP with sc-CO 2 . EEP yields of 39.5% were obtained and maximum global extraction yields were 7.3% for SFE with no co-solvent, 51% for SFE with 15% ethanol and 18% for the FSCE extract fraction. The concentrations of the markers in the different extracts differed as a function of the operational parameters, indicating that the addition of co-solvent and the selectivity of sc-CO 2 could be manipulated so as to obtain extracts with the yields and concentrations of interest.

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Comparison of the Anti-Herpes Simplex Virus Activities of Propolis and 3-Methyl-but-2-enyl Caffeate

Cited by 153 publications

References 10 publications

Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Salt stress enhancement of antioxidant and antiviral efficiency of Spirulina platensis

Supercritical CO2 extraction of raw propolis and its dry ethanolic extract

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