Comparison of the anti-inflammatory effects of different polar ginsenosides on rheumatoid arthritis

Feng, Jing; Yu, Yuan; Song, Linmeng; Zhang, Ruoyu; Cao, Yuqing; Du, Xiang; Tao, Feiyan; Gao, Hong; Peng, Xue

doi:10.1016/j.indcrop.2022.114845

Cited by 5 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, compared with other ginsenosides, Rg5 showed better inhibitory effects on MUC production. Low-polarity ginsenosides, such as Rg5, are associated with better anti-inflammatory activity in comparison to polar ginsenosides [ [48] , [49] , [50] ]. In addition, Rg5 not only has anti-allergic effects but also exhibits better pharmacokinetic properties compared with other ginsenosides [ [51] , [52] , [53] ].…”

Section: Discussionmentioning

confidence: 99%

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Heo

Kim²,

Cha³

et al. 2023

Journal of Ginseng Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Heo

Kim²,

Cha³

et al. 2023

Journal of Ginseng Research

View full text Add to dashboard Cite

“…Metabolomics technology has been widely used to reveal the mechanisms of disease occurrence and pharmacodynamics. 19 Compared with normal individuals (rat models), patients with hyperlipidemia (rat models) exhibit different metabolic spectrum characteristics in their serum or urine. 21 The regulation of endogenous metabolite levels through phytochemical interventions to improve hyperlipidemia and NAFLD has attracted considerable attention in recent years.…”

Section: Discussionmentioning

confidence: 99%

“…Metabolomics technology has been widely used to reveal the mechanisms of disease occurrence and pharmacodynamics 19 . Compared with normal individuals (rat models), patients with hyperlipidemia (rat models) exhibit different metabolic spectrum characteristics in their serum or urine 21 .…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, metabolomics based on ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) has been widely used to discover differential metabolites and metabolic pathways, which is conducive to revealing the pathogenesis and therapeutic targets of diseases. 19 It has focused on serum, urine, feces and target organs. 20,21 Endogenous metabolites could alter the phenotype of an organism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Saponins from Chenopodium quinoa Willd. husks alleviated high‐fat‐diet‐induced hyperlipidemia via modulating the gut microbiota and multiple metabolic pathways

Yu,

Ji,

Song

et al. 2023

J Sci Food Agric

Self Cite

View full text Add to dashboard Cite

BackgroundHyperlipidemia is characterized by abnormally elevated blood lipids. Quinoa saponins (QS) have multiple pharmacological activities, including antitumor, bactericidal and immune‐enhancing effects. However, the lipid‐lowering effect and mechanisms of QS in vivo have been scarcely reported.MethodsThe effect of QS against hyperlipidemia induced by high‐fat diet in rats was explored based on gut microbiota and serum non‐targeted metabolomics.ResultsThe study demonstrated that the supplementation of QS could reduce serum lipids, body weight, liver injury and inflammation. 16S rRNA sequencing demonstrated that QS mildly increased alpha‐diversity, altered the overall structure of intestinal flora, decreased the relative richness of Firmicutes, the ratio of Firmicutes/Bacteroidetes (P < 0.05) and increased the relative richness of Actinobacteria, Bacteroidetes, Bifidobacterium, Roseburia and Coprococcus (P < 0.05). Simultaneously, metabolomics analysis showed that QS altered serum functional metabolites with respect to bile acid biosynthesis, arachidonic acid metabolism and taurine and hypotaurine metabolism, which were closely related to bile acid metabolism and fatty acid β‐oxidation. Furthermore, QS increased protein levels of farnesoid X receptor, peroxisome proliferator‐activated receptor α and carnitine palmitoyltransferase 1, which were related to the screened metabolic pathways. Spearman correlation analysis showed that there was a correlation between gut microbiota and differential metabolites.ConclusionQS could prevent lipid metabolism disorders in hyperlipidemic rats, which may be closely associated with the regulation of the gut microbiota and multiple metabolic pathways. This study may provide new evidence for QS as natural active substances for the prevention of hyperlipidemia. © 2023 Society of Chemical Industry.

show abstract

Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects

et al. 2023

View full text Add to dashboard Cite

Comparison of the anti-inflammatory effects of different polar ginsenosides on rheumatoid arthritis

Cited by 5 publications

References 47 publications

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

A systematic exploration of ginsenoside Rg5 reveals anti-inflammatory functions in airway mucosa cells

Saponins from Chenopodium quinoa Willd. husks alleviated high‐fat‐diet‐induced hyperlipidemia via modulating the gut microbiota and multiple metabolic pathways

Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects

Contact Info

Product

Resources

About