Comparison of the Antibacterial Activity and Effect on Membrane Permeability of Hibiscus Acid and a Commercial Chlorhexidine Mouthrinse Against Pathogenic Oral Bacteria and Determination of Hibiscus Acid Toxicity

Baena-Santillán, Elena Saraí; Piloni‐Martini, Javier; Rangel‐Vargas, Esmeralda; Gómez‐Aldapa, Carlos A.; Sánchez-Gutiérrez, Manuel; Madrigal-Santillán, Eduardo O.; Castro-Rosas, Javier

doi:10.1089/jmf.2020.0207

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…In recent years, a broad family of synthetic compounds known as peptoids [32] has emerged and many of these have both amphiphilic and antimicrobial properties [33][34][35][36][37]. The amphiphiles that disrupt or enhance the permeability of membranes [38][39][40] are often effective antimicrobials and typically exhibit a low rate of resistance development. As such, amphiphiles present an attractive target for antimicrobial drug development.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Adjuvant Potencies of Di-n-alkyl Substituted Diazalariat Ethers

Patel,

Spikes,

Bailey

et al. 2023

Antibiotics

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Lariat ethers are macrocyclic polyethers—crown ethers—to which sidearms are appended. 4,13-Diaza-18-crown-6 having twin alkyl chains at the nitrogens show biological activity. They exhibit antibiotic activity, but when co-administered at with an FDA-approved antibiotic, the latter’s potency is often strongly enhanced. Potency enhancements and resistance reversals have been documented in vitro for a range of Gram-negative and Gram-positive bacteria with a variety of antimicrobials. Strains of E. coli and Staphylococcus aureus having resistance to a range of drugs have been studied and the potency enhancements (checkerboards) are reported here. Drugs included in the present study are ampicillin, cefepime, chlortetracycline, ciprofloxacin, doxycycline, kanamycin, minocycline, norfloxacin, oxycycline, penicillin G, and tetracycline. Enhancements of norfloxacin potency against S. aureus 1199B of up to 128-fold were observed. The properties of these lariat ethers have been studied to determine solubility, their membrane penetration, cytotoxicity and mammalian cell survival, and their effect on bacterial efflux pumps. It is shown that in some cases, the lariat ethers have complex antimicrobials with considerable selectivity. Based on these observations, including 1:1 complexation between lariat ethers and antimicrobials and the cytotoxicity of the MeI salts showing a separation index of 32-fold, they hold significant potential for further development.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and Adjuvant Potencies of Di-n-alkyl Substituted Diazalariat Ethers

Patel,

Spikes,

Bailey

et al. 2023

Antibiotics

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“…2022 ), E. coli (enteroinvasive, enteropathogenic, enterohemorrhagic and Shiga toxin-producing) ( Portillo-Torres et al. 2019 ), Streptococcus mutans , S. sanguinis , Capnocytophaga gingivalis , and Staphylococcus aureus ( Baena-Santillan et al. 2022 ), and Pseudomonas aeruginosa ( Cortes-Lopez et al.…”

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confidence: 99%

“…Although the complete mechanism of the effect of hibiscus acid on the bacterial cell is not well known, evidence suggests that hibiscus acid alters the bacterial membrane ( Portillo-Torres et al. 2019 ; Baena-Santillan et al. 2022 ; Sedillo-Torres et al.…”

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confidence: 99%

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A natural approach to combating antibiotic-resistant pathogens in livestock: Hibiscus sabdariffa-derived hibiscus acid as a promising solution

Rangel-Vargas,

Gomez-Aldapa,

Falfan-Cortes

et al. 2024

Vet. Med. - Czech

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We examined the antibacterial efficacy of streptomycin, hibiscus acid, and their combination against multidrug-resistant Shiga-toxin-producing Escherichia coli (STEC) and Salmonella Typhimurium in mice. We determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for streptomycin, hibiscus acid, and their combination against STEC and Salmonella . Fifteen sets of six mice in each set were utilised: six groups were orally exposed to 4 log 10 colony forming units (CFUs) of S. Typhimurium and another six to STEC, and three acted as the controls. Six hours post-inoculation, specific groups of mice received either oral solutions containing hibiscus acid at 5 and 7 mg/ml; streptomycin at 50 and 450 μg/ml; hibiscus acid/streptomycin (5 mg/ml hibiscus acid and 50 μg/ml streptomycin); or isotonic saline. The study determined the MIC and MBC of 7 mg/ml of hibiscus acid; 300 and 450 μg/ml of streptomycin; and two concentrations of hibiscus/streptomycin (3 mg/ml / 20 μg/ml and 5 mg/ml / 50 μg/ml). Interestingly, the mice that were infected and subsequently treated with hibiscus acid at 7 mg/ml alone or in conjunction with streptomycin did not have either STEC or Salmonella in their faecal samples, and none of the mice died. In contrast, the untreated mice and those exclusively treated with streptomycin had the pathogens present in their stool, leading to the mortality of all the subjects.

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Potential effect of Roselle (Hibiscus sabdariffa) ethanol extract against Streptococcus mitis and Streptococcus oralis

Salah,

Haleem,

Mazin

2023

Journal of Herbal Medicine

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Comparison of the Antibacterial Activity and Effect on Membrane Permeability of Hibiscus Acid and a Commercial Chlorhexidine Mouthrinse Against Pathogenic Oral Bacteria and Determination of Hibiscus Acid Toxicity

Cited by 3 publications

References 16 publications

Antimicrobial and Adjuvant Potencies of Di-n-alkyl Substituted Diazalariat Ethers

Antimicrobial and Adjuvant Potencies of Di-n-alkyl Substituted Diazalariat Ethers

A natural approach to combating antibiotic-resistant pathogens in livestock: Hibiscus sabdariffa-derived hibiscus acid as a promising solution

Potential effect of Roselle (Hibiscus sabdariffa) ethanol extract against Streptococcus mitis and Streptococcus oralis

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