Comparison of the antibacterial activity of modified‐cotton with magainin I and LL‐37 with potential as wound‐dressings

Abstract

Wounds are the ideal setting for the development of micro‐organisms, so it is often necessary to apply a dressing to control bacterial colonization. Cotton is commonly used in dressings, as it exhibits important hydrophilic characteristics such as high moisture and fluid retention properties, but it may provide a sustainable media for the development of micro‐organisms. In this way, the development of new strategies to provide cotton materials with lasting and effective antimicrobial properties is of the utmost importance. Consequently, here we described two processes to develop cotton‐dressings functionalized with antimicrobial peptides (AMPs) magainin I (MagI) and LL‐37, in order to give cotton‐dressings an antibacterial effect. The AMPs showed no cytotoxic effect against human fibroblasts so they are safe to contact with skin. In addition, the functionalized materials with either LL‐37 or MagI present an antimicrobial effect exhibiting inhibition ratios of 89% against Klebsiella pneumoniae and 58% against Staphylococcus aureus, respectively. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40997.

Electrospinning polypropylene with an amino acid as a strategy to bind the antimicrobial peptide Cys-LC-LL-37

“…The use of L-Cys and AMPs in cosmetic industry and their natural presence in the skin, hair and nails of human beings offers a guarantee of biocompatibility and non-toxicity once in prolonged contact with the body. These guarantees were already proven by our recent results regarding the biofunctionalization of cotton [19,20], silk textiles [21,22] and polycaprolactone foam grafted with L-Cys [23], along with a low MIC value, high durability and safety both for user and environment. In general, cationic AMPs with the best antimicrobial activity are those that have the charged and hydrophilic portions to either side with a hydrophobic portion inbetween [24].…”

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

“…Thus, we developed a composite wound dressing based on products from natural sources, cotton, cyclodextrins, and cellulose. The cotton still is a standard dressing for wound management, since it offers mechanical support and gas and water permeability . Cellulose, as the main component of cotton, is nontoxic, homeostatic, nonallergic, and biocompatible .…”

Formation, antimicrobial activity, and controlled release from cotton fibers with deposited functional polymers

“…A general problem in hospitals and healthcare institutions is microbial contamination of surfaces of wound treating materials, including textiles (sheets, gowns, etc. ), their contamination can cause infections in open wounds and consequently result in cross‐infections . Thus, antimicrobial activity in textiles for these applications is strongly required.…”

“…), their contamination can cause infections in open wounds and consequently result in cross-infections. 4,25 Thus, antimicrobial activity in textiles for these applications is strongly required. Figure 10 shows the results as percentage of growth inhibition rate obtained for gram negative bacteria E. coli and gram-positive bacteria S. aureus cultivated on the surface of bleached white cotton (control) and layer-by-layer modified cotton fibers.…”