Comparison of the Antibacterial Efficacy of Manuka Honey Against E.faecalis and E.coli – An In vitro Study

Nd, Kumar; Rs, Kalluru; Ahmed, Sadaf; Abhilashini, A; Jayaprakash, Teenus; Garlapati, Roopadevi; Sowmya, B; Kn, Reddy

doi:10.7860/jcdr/2014/9676.4738

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…Although no study has report bacterial resistance to honey, Gram-positive isolates of Bacillus cereus and S. aureus exhibited increased in vitro sensitivity to Sidr honey (33% w/v), evidenced by the large zone of inhibition (36 mm and 34 mm, respectively) compared to E.coli and Salmonella enteritidis (27 mm and 23 mm, respectively) [31]. This is in line with previous reports where the inhibition of Gram-positive bacteria (Enterococcus faecalis and S. aureus) at lower the concentration of Manuka honey was observed while its absent/limited effect on Gram-negative bacteria (P. aeruginosa and E. coli) [32].…”

Section: Saudi Honeysupporting

confidence: 92%

Saudi Honey: A Promising Therapeutic Agent for Treating Wound Infections

Bazaid¹,

Aldarhami²,

Gattan³

et al. 2021

Cureus

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Treatment of wounds, especially chronic ones, is a major challenge in healthcare, with serious clinical and economic burdens. Multiple treatment approaches, including the usage of silver and iodine, have dramatically improved wound healing and reduced the incidence of infection. However, once infected by drug-resistant bacteria, treatment of wounds becomes a serious complication, with limited availability of effective antibiotic drugs, leading to high morbidity and mortality. Therefore, alternative therapeutic agents are required to address this gap in wound management. The introduction of manuka honey as a therapeutic agent against infected wounds was the result of extensive research about its activity against both planktonic and biofilm bacterial growth. Likewise, several types of Saudi honey (e.g., Sidr and Talh) showed promising in vitro and in vivo antimicrobial activity against wound pathogens. This short review summarizes literature that investigated the activity of common types of Saudi honey in relation to wound infections and explores their clinical utility.

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Section: Saudi Honeysupporting

confidence: 92%

Saudi Honey: A Promising Therapeutic Agent for Treating Wound Infections

Bazaid¹,

Aldarhami²,

Gattan³

et al. 2021

Cureus

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“…In a study carried out, the researchers compared the antibacterial effect of Manuka honey against Enterococcus faecalis and E. coli, a Gram-positive and a Gram-negative bacterium. The results from this study indicated that Gram-negative bacteria might be more resistant when exposed to Manuka honey [35].…”

Section: Honey's Use In Alternative Therapymentioning

confidence: 63%

Antibacterial activity of Manuka honey and its components: An overview

et al. 2018

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The importance of honey for medicinal purposes is well documented in some of the world's oldest literature. Honey is well known and studied for its antimicrobial properties. The medicinal properties in honey originate from the floral source used by bees. Manuka honey is a dark monofloral honey rich in phenolic content, and currently it is gaining much attention for its antimicrobial activity. Researchers have found that honey is effective against a wide range of pathogens. The antibacterial potency of Manuka honey was found to be related to the Unique Manuka Factor (UMF) rating, which is correlated with the methylglyoxal and total phenols content. It is reported that different types of Manuka honey have differing effects and Gram-negative bacteria are more resistant than Gram-positive bacteria. Bacterial resistance to honey as antimicrobial agent has yet to be identified, possibly due to the presence of a complex mixture of methylglyoxal and other components. Honey is also reported to alter a bacterium's shape and size through septal ring alteration, which affects cell morphology and growth. Research has shown that Manuka honey of different UMF values has medicinal properties of interest and it can be beneficial when used as a combination treatment with other antimicrobial agents.

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“…This high content also confers a high antioxidant and antibacterial capacity, which allows it to be considered a medicinal honey. This has led to the use of Manuka honey as a reference for the comparison of bioactive compounds with others of a distinct botanical and geographical origin [ 54 , 87 , 92 , 95 , 105 , 106 , 107 ]. Regarding the comparison of the content of phenolic compounds of Manuka honey with others, such as Polish honeys, no significant differences were found ( p ≤ 0.05) in the TPC of buckwheat honey (211.0 ± 11.4 mg GAE/100 g) and honeydew (201.0 ± 9.9 mg GAE/100 g), compared to the values of the commercial Manuka honey.…”

Section: Phenolic Compounds As Indicators Of the Botanical Origin Of Honeymentioning

confidence: 99%

Phenolic Compounds in Honey and Their Relationship with Antioxidant Activity, Botanical Origin, and Color

et al. 2021

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Honey has been employed since antiquity due to its sensory, nutritional, and therapeutic properties. These characteristics are related to its physical and chemical composition. For example, phenolic compounds are substances that can determine antioxidant activity, as well as sensory characteristics, and can be employed as biomarkers of floral and geographical origin. This has generated a growing interest in the study of phenolic compounds and their influence in the intrinsic properties of this beekeeping product. This review aims to summarize, analyze, and update the status of the research that demonstrates the role of phenolic compounds in antioxidant activity, botanical-geographical origin, and the sensory characteristics of honey. These phenolic compounds, according to various results reported, have great relevance in honey’s biological and functional activity. This leads to research that will link phenolic compounds to their floral, geographical, productive, and territorial origin, as well as some sensory and functional characteristics.

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Comparison of the Antibacterial Efficacy of Manuka Honey Against E.faecalis and E.coli – An In vitro Study

Cited by 8 publications

References 12 publications

Saudi Honey: A Promising Therapeutic Agent for Treating Wound Infections

Saudi Honey: A Promising Therapeutic Agent for Treating Wound Infections

Antibacterial activity of Manuka honey and its components: An overview

Phenolic Compounds in Honey and Their Relationship with Antioxidant Activity, Botanical Origin, and Color

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