Comparison of the Anticonvulsant Activities of Substituted Hydroxycoumarins and 4-[(3-Nitro-2-Oxo-2H-Chromen-4-Yl)Amino]Butanoic Acid

Yakovleva, E. E.; Мызников, Л. В.; Шабанов, П. Д.

doi:10.1007/s11094-020-02294-9

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…The anticonvulsant activity of the studied compounds decreased if substituents were added to the coumarin 4th position. The nitro derivative ( 53 ) exhibited pronounced anticonvulsant properties, at a dose of 5 mg/kg statistically significantly shortened the duration of convulsions mice that received nicotine, and at a dose of 20 mg/kg significantly lengthened the LPs for death and convulsions of animals in the corazole antagonism tests 95 . Stanislav and co‐workers demonstrated several coumarin‐aroylhydrazone‐based molecular hybrids as anti‐seizure agents in MES‐induced seizures and in the formalin test.…”

Section: Resultsmentioning

confidence: 99%

Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship

Keri

Budagumpi

Somappa

2022

Clinical Pharmacy Therapeu

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What is known and objective:The main objective of this review is to highlight the most relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a panoramic view to the biologists/medicinal chemists working in this area and would assist them in their efforts to design, synthesize and extract (from natural source) coumarin-based anticonvulsant agents. Also, the structure-activity relationship (SAR) studies are also discussed for further rational design of this kind of derivatives. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic coumarin-based antiepileptic agents.

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Section: Resultsmentioning

confidence: 99%

Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship

Keri

Budagumpi

Somappa

2022

Clinical Pharmacy Therapeu

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“…The antiepileptic effect of derivative 25 at a dose of 200 mg/kg was comparable to that of reference valproic acid at the same dose. A further increase in the dose to 300 mg/kg led to an increase in the anticonvulsant activity of 25 [73].…”

Section: Antiepileptic Agentsmentioning

confidence: 99%

“…The antiepileptic effects of 7-hydroxycoumarin derivatives may be associated with the synergistic effect on γ-aminobutyric acid ionotropic receptors (GABA A ). In the reaction of 7hydroxycoumarin and 2-chloro-1-morpholinoethan-1-one, Yakovleva and collaborators synthesized umbelliferone derivative 25 (Figure 14) containing a morpholine-acetamide group at position C-7 [73]. Compound 25 showed pronounced antiepileptic activity in the corazole-GABA A receptor antagonist convulsion test.…”

Section: Antiepileptic Agentsmentioning

confidence: 99%

Umbelliferone and Its Synthetic Derivatives as Suitable Molecules for the Development of Agents with Biological Activities: A Review of Their Pharmacological and Therapeutic Potential

Kornicka,

Balewski,

Lahutta

et al. 2023

Pharmaceuticals

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Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that possesses a wide variety of pharmacological properties. In addition, the use of nanoparticles containing umbelliferone may improve anti-inflammatory or anticancer therapy. Also, its derivatives are endowed with great potential for therapeutic applications due to their broad spectrum of biological activities such as anti-inflammatory, antioxidant, neuroprotective, antipsychotic, antiepileptic, antidiabetic, antimicrobial, antiviral, and antiproliferative effects. Moreover, 7-hydroxycoumarin ligands have been implemented to develop 7-hydroxycoumarin-based metal complexes with improved pharmacological activity. Besides therapeutic applications, umbelliferone analogues have been designed as fluorescent probes for the detection of biologically important species, such as enzymes, lysosomes, and endosomes, or for monitoring cell processes and protein functions as well various diseases caused by an excess of hydrogen peroxide. Furthermore, 7-hydroxy-based chemosensors may serve as a highly selective tool for Al3+ and Hg2+ detection in biological systems. This review is devoted to a summary of the research on umbelliferone and its synthetic derivatives in terms of biological and pharmaceutical properties, especially those reported in the literature during the period of 2017–2023. Future potential applications of umbelliferone and its synthetic derivatives are presented.

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“…Известно, что большинство кумаринов обладает антикоагулянтым [9], противовоспалительным [10], антимикробным [11], антигипоксическим [12], противоопухолевым [13] действием. Среди нейроактивных производных кумарина известны соединения с противосудорожным [14] и антидепрессантным [15] действием. Фармакологических исследований в отношении действия кумаринов в игровой зависимости ранее проведено не было.…”

Section: актуальностьunclassified

Effect of new coumarin derivatives on the impulsive and compulsive components of gambling addiction in rats

Daliev,

Lebedev,

Bychkov

et al. 2024

Rev Clin Pharm Drug Ther

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The search for new neuroactive compounds that have a selective effect on the mechanisms of emotional reinforcement in gambling addiction is of interest. There have been no previous studies on the effects of coumarins on gambling addiction. Aim. The aim of our work was to study the effect of new coumarin derivatives on the impulsive and compulsive components of gambling addiction in rats. Materials and methods. The effects of drugs on elements of gambling addiction were assessed in rats in the marble burying test and probability and magnitude of reinforcement in the three-arm maze, a version of the IOWA test. The effect of 6 coumarin derivatives was studied - LVM-091, LVM-092, LVM-096, LVM-099, LVM-S144, IEM-2886 Results and its discussion. In the burrowing balls test, substances synthesized on the basis of coumarin LVM-092, LVM-099, LVM-S144, IEM-2886 reduced the level of compulsivity, reducing the number of buried balls compared to the control group and the diazepam group (p0.05). In the probability and magnitude of reinforcement test, after the administration of drugs LVM-091, LVM-099 LVM-S144 and IEM-2886, the level of impulsivity and risk behavior decreased, reducing the number of animals entering the sleeve with the greatest reinforcement and its low probability. Conclusion. New coumarin derivatives cause an anticompulsive effect and reduce the level of impulsivity in rats, which in the future can be used in the treatment of obsessive-compulsive disorders and addictive conditions, such as Internet addiction and gaming addiction.

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Comparison of the Anticonvulsant Activities of Substituted Hydroxycoumarins and 4-[(3-Nitro-2-Oxo-2H-Chromen-4-Yl)Amino]Butanoic Acid

Cited by 5 publications

References 9 publications

Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship

Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship

Umbelliferone and Its Synthetic Derivatives as Suitable Molecules for the Development of Agents with Biological Activities: A Review of Their Pharmacological and Therapeutic Potential

Effect of new coumarin derivatives on the impulsive and compulsive components of gambling addiction in rats

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