Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain

Ortega-Álvaro, A.; Berrocoso, Esther; Rey-Brea, Raquel; Leza, Juan C.; Micó, Juan Antonio

doi:10.1016/j.lfs.2011.10.002

Cited by 22 publications

(21 citation statements)

References 43 publications

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“…Furthermore, L-arginine exerts antiallodynic effects in CCI rats exposed to cold stimuli. 12 Taken together, it is plausible to investigate possible beneficial effects of ibuprofen and L-arginine in DN.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

“…Ibuprofen + L-arginine was freshly prepared by mixing ibuprofen and L-arginine together in one syringe to be administered at dose of 100 mg/kg each. 12 STZ, ibuprofen sodium and L-arginine were purchased from Sigma Aldrich, USA. After 3 successive blood glucose measurements above 300 mg/dL, insulin glargine (Lantus, Sanofi-Aventis, US) was used at a dose of 0.5 unit every other day.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

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Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

El-Lithy

El-Bakly

Matboli

et al. 2016

Translational Research

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Section: A N U S C R I P Tmentioning

confidence: 99%

Section: Drugs and Chemicalsmentioning

confidence: 99%

Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

El-Lithy

El-Bakly

Matboli

et al. 2016

Translational Research

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“…Therefore, it can be used to relieve pain, reduce fever and swelling [2]. Ibuprofen can be effectively used in the treatment of mild to moderate pain, but it is not recommended for the treatment of neuropathic pain [30]. Collins et al [7] assessed the analgesic effect of ibuprofen on moderate-to-severe pain, comparing it with placebo and diclofenac.…”

mentioning

confidence: 99%

“…The recommended dose per person is 200 to 400 mg every 4 to 6 hours; a maximum daily dose is 1.2 g [26]. Orally administrated ibuprofen delayed analgesic action in many formulations, especially in the form of tablets [30]. Ibuprofen causes the smallest range of side effect among the non-selective NSAIDs.…”

mentioning

confidence: 99%

“…However, common side effects, which occur after taking ibuprofen are: diarrhea, dyspepsia, nausea, headaches, hypertension and hearing loss [9]. By combining L-arginine (amino acid) and the racemic ibuprofen, a highly soluble salt (ibuprofen arginate) can be obtained [30]. The L-arginate salt of ibuprofen can lead to a better analgesic effect and fewer side effects than racemic ibuprofen because arginine can reduce oxidative stress induced by ibuprofen and it is less toxic for the gastrointestinal tract [30].…”

mentioning

confidence: 99%

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Review on analgesic effect of co-administrated ibuprofen and caffeine

Polski

Kasperek

Sobótka-Polska

et al. 2014

Current Issues in Pharmacy and Medical Sciences

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Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

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Photoswitchable Carbamazepine Analogs for Non‐Invasive Neuroinhibition In Vivo

Camerin,

Maleeva,

Gomila

et al. 2024

Angewandte Chemie

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A problem of systemic pharmacotherapy is off‐target activity, which causes adverse effects. Outstanding examples include neuroinhibitory medications like antiseizure drugs, which are used against epilepsy and neuropathic pain but cause systemic side effects. There is a need of drugs that inhibit nerve signals locally and on‐demand without affecting other regions of the body. Photopharmacology aims to address this problem with light‐activated drugs and localized illumination in the target organ. Here, we have developed photoswitchable derivatives of the widely prescribed antiseizure drug carbamazepine. For that purpose, we expanded our method of ortho azologization of tricyclic drugs to meta/para and to N‐bridged diazocine. Our results validate the concept of ortho cryptoazologs (uniquely exemplified by Carbazopine‐1) and bring to light Carbadiazocine (8), which can be photoswitched between 400‐590 nm light (using violet LEDs and halogen lamps) and shows good drug‐likeness and predicted safety. Both compounds display photoswitchable activity in vitro and in translucent zebrafish larvae. Carbadiazocine (8) also offers in vivo analgesic efficacy (mechanical and thermal stimuli) in a rat model of neuropathic pain and a simple and compelling treatment demonstration with non‐invasive illumination.

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Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain

Cited by 22 publications

References 43 publications

Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

Review on analgesic effect of co-administrated ibuprofen and caffeine

Photoswitchable Carbamazepine Analogs for Non‐Invasive Neuroinhibition In Vivo

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