2020
DOI: 10.1016/j.virol.2020.01.017
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Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission

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Cited by 7 publications
(6 citation statements)
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“…This agrees with prior findings in vitro and in vivo in mice with cyanovirin (Smee et al, 2008). Griffithsin has been shown to inhibit a number of enveloped viruses, but to our knowledge, this is the first demonstration of antiviral activity for IAV (Alexandre et al, 2020). The activity of griffithsin was somewhat less than that of cyanovirin, in general.…”
Section: Discussionsupporting
confidence: 90%
“…This agrees with prior findings in vitro and in vivo in mice with cyanovirin (Smee et al, 2008). Griffithsin has been shown to inhibit a number of enveloped viruses, but to our knowledge, this is the first demonstration of antiviral activity for IAV (Alexandre et al, 2020). The activity of griffithsin was somewhat less than that of cyanovirin, in general.…”
Section: Discussionsupporting
confidence: 90%
“… Lectin (Griffithsin) In vivo, antiviral Mannose-binding lectin binds with viral envelope GPs, inhibiting viral infection of HIV-1, HSV, and HPV [ 75 ] In vitro, antiviral Mannose-binding lectin binds with Spike GPs, inhibiting viral infection of SARS-CoV [ 82 ] In vitro, antiviral Griffithsin and synthetic polymers showed high virucidal activity in cell-associated HIV-1 and in the presence of seminal and vaginal simulants. Blocking of CD4+ viral binding [ 83 ] Grateloupia chiangii Lectin In vitro, antiviral Mannose-binding lectin binds with viral envelope GPs, inhibiting viral infection of Influenza H1N1 and HSV1/2 [ 79 ] Kappaphyrus alvarezii Lectin In vitro, antiviral Mannose-binding lectin binds to Influenza hemagglutinin and HIV GP gp120, avoiding infection [ 84 ] Kappaphycus striatum Lectin In vitro, antimicrobial Growth inhibition of Vibrio alginolyticus (25.4 μg/mL) and Enterococcus cloacae (101.6 μg/mL). Did not inhibit other Vibrio spp., Staphylococcus aureus , or Escherichia coli [ 85 ] Gracilaria fisheri Lectin In vivo, antimicrobial There was >50% mortality reduction in 100 μg/mL treated shrimp, related with agglutination of Vibrio parahaemolyticus …”
Section: Bioactive Properties and Mechanisms Of Actionmentioning
confidence: 99%
“…Griffithsin well-known anti-viral lectin, was expressed in Lactobacillus rhamnosus GR-1 probiotic strains for vaginal mucosal delivery of lectin to inhibit HIV transmission and subsequent replication [ 27 ]. Another research group has used Nicotiana benthamiana as the expression to over express Griffithsin lectin (as an HIV-1 entry inhibitor) by using three gene silencing suppressors, with a yield of 400 μg/g fresh weight after expression which was reduced to 287 μg/g after purification with a total recovery of 71.75% [ 28 ]. Later on, the monomeric Griffithsin lectin was linked in tandem repeats of two (2MG and 2MG3), three (3MG) and four (4MG) units and found that 2MG and 2MG3 tandemers had similar activity to Griffithsin against cell-free and cell-associated HIV-viruses, while 3MG and 4MG were significantly more potent than monomeric Griffithsin against HIV-viruses [ 29 ].…”
Section: Algal Lectins Against Antivirus Propertiesmentioning
confidence: 99%