Comparison of the application of 18F-FDG and 68Ga-DOTATATE PET/CT in neuroendocrine tumors: A retrospective study

Hu, Xianwen; Li, Dandan; Wang, Rui; Wang, Pan; Cai, Jiong

doi:10.1097/md.0000000000033726

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…The main advantage of nuclear medicine is that different radiopharmaceuticals can be synthesized for targeted imaging based on receptors expressed in the lesion. 18 F-FDG PET/CT, a common functional imaging technique, has been widely used in the localization, differential diagnosis, staging and post-treatment response assessment of a variety of primary tumors; however, it has shown limited value in the diagnosis and differential diagnosis of neuroendocrine tumors, including insulinoma ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…New imaging techniques in nuclear medicine, including PET/CT imaging with 68 Ga-somatostatin receptors, such as 68 Ga-DOTATATE, and 68 Ga-glucagon-like peptide-1 (GLP-1) receptor analogs, such as 68 Ga-DOTA-exendin-4, can facilitate the localization and diagnosis of insulinoma to distinguish it from other tumors such as pancreatic cancer and pancreatic cystadenoma ( 7 , 17 , 18 ). Due to the high expression of somatostatin receptors, insulinomas show significant radioactivity uptake on 68 Ga-somatostatin receptor and 68 Ga-GLP-1 receptor analog PET/CT imaging ( 7 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report

Zhu,

Xie,

2023

Exp Ther Med

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Nesidioblastosis is a rare cause of hyperinsulinemic hypoglycemia in adults and its clinical features are similar to those of insulinoma with recurrent hypoglycemic attacks. The present study reports the case of a 48-year-old man who visited the Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a 5-year history of recurrent hypoglycemic symptoms such as dizziness and palpitations. Abdominal magnetic resonance imaging (MRI) showed a mass of ~1.2x1.0 cm in the head of the pancreas, which was suspected to be an insulinoma. For confirmation, the patient underwent both fluorine-18-fluorodeoxyglucose ( 18 F-FDG) and gallium-68-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-teraacetic acid-d-Phel-Tyr3-Thr8-OC ( 68 Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT), which showed a moderately increased uptake of 18 F-FDG but no uptake of 68 Ga-DOTATATE in the corresponding lesion. The patient subsequently underwent surgery to remove the lesion, which was pathologically confirmed as a pancreatic nesidioblastosis. This case showed that nesidioblastosis should be considered a differential diagnosis for insulinoma and that dual nuclear tracer PET/CT imaging is helpful for differentiating between the two. If conventional imaging techniques such as ultrasound, CT and MRI cannot identify the cause of hypoglycemia in future cases, dual-nuclide tracer PET/CT imaging should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report

Zhu,

Xie,

2023

Exp Ther Med

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“…18 F-FDG PET/CT. The production of 18 F-FDG and PET/CT (Biograph mCT, Siemens, Germany) scanning parameters were conducted based on our previously published literature (7).…”

Section: Image Acquisitionmentioning

confidence: 99%

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

Hu,

Li,

Xiong

et al. 2024

Front. Oncol.

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IntroductionEpithelioid hemangioma (EH) is an intermediate locally aggressive tumor that consists of epithelioid cells and endothelial cell differentiation, which can occur at any age, but is most common between the ages of 30 and 40 years. EH in the thoracic spine is rare, and accurate diagnosis is critical to treatment planning. Our aim was to explore the imaging and clinical data of thoracic spine EH to improve the understanding of this rare disease.MethodsFrom January 1, 2018 to June 30, 2023, a database of thoracic spine masses was retrospectively reviewed. Five patients with histologically proven thoracic spine EH and complete imaging available were identified and analyzed. Computed tomography (CT) and magnetic resonance imaging (MRI) findings were evaluated separately by two radiologists with more than 10 years of experience. Positron emission tomography (PET)/CT was conducted by two nuclear medicine diagnostic technologists with at least 5 years of experience.ResultsThe patients included three male and two female patients aged 23 to 56 years (mean age was 38.4 ± 14.3 years). All patients underwent CT, MRI, and 18F-FDG PET/CT examination before treatment. Four patients were limited to one vertebral involvement, only one patient had multiple vertebral involvement, and all tumors involved the accessories, including one involving the posterior ribs. The maximum diameter of the tumor ranged from 2.7 to 4.3.ConclusionsCT, MRI, and 18F-FDG PET/CT findings of thoracic spine EH have certain characteristics, and understanding these imaging findings will help to obtain accurate diagnosis before surgery.

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“…However, its diagnostic value for cystic lesions is limited. Numerous studies have demonstrated that Ga68 SSA-PET([ 68 Ga]Ga-DOTANOC, [ 68 Ga]Ga-DOTATOC, [ 68 Ga]Ga-DOTATATE) imaging offers higher diagnostic accuracy for NETs (2)(3)(4)(5). While 68Ga labeling has the advantage of eluting isotopes from a generator, fluorine labeling offers benefits like longer half-life, improved spatial resolution, higher production yield, and consistent advantages in imaging and logistics.…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of primary hepatic neuroendocrine tumor diagnosed by Al18F-NOTA-Octreotide PET/CT: a case report

Zhang,

2023

Front. Med.

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Neuroendocrine tumors (NETs) are a heterogeneous group of tumors originating from peptide-producing neurons and neuroendocrine cells. The liver is the most common site of metastasis for NETs, while primary hepatic neuroendocrine tumors (PHNETs) are exceedingly rare. While somatostatin receptor scintigraphy (SRS) has demonstrated superior efficacy compared to [18F]FDG PET imaging in the diagnosis of neuroendocrine tumors, [18F]AlF-NOTA-Octreotide ([18F]AlF-OC) PET/CT also exhibits specific advantages over SRS. This article presents a case study of a patient with a liver mass who underwent sequential [18F]FDG and [18F]AlF-OC PET/CT scans, ruling out hepatocellular carcinoma and confirming the diagnosis of PHNETs. Subsequently, the patient underwent surgical treatment. From another perspective, [18F]AlF-OC exhibits distinct advantages. The postoperative pathology revealed a PHNETs, which further emphasizes its clinical rarity.

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Comparison of the application of 18F-FDG and 68Ga-DOTATATE PET/CT in neuroendocrine tumors: A retrospective study

Cited by 6 publications

References 19 publications

Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report

Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report

CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study

Surgical treatment of primary hepatic neuroendocrine tumor diagnosed by Al18F-NOTA-Octreotide PET/CT: a case report

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