Comparison of the bioactive components of the ecotypes and cultivars of plantain (<i>Plantago lanceolata</i> L.) herbs

Al-Mamun, Mohammad; Abe, Daisuke; Kofujita, Hisayoshi; Tamura, Yasuaki; Sano, Hiroaki

doi:10.1111/j.1740-0929.2007.00501.x

Cited by 20 publications

(13 citation statements)

References 22 publications

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“…Analysis of proximate components of the experimental diets were performed according to AOAC 10 as described before 11 and the total polyphenol contents of hop was determined according to Folin-Denis method 12 as described in our previous paper 13. The NH 3 -nitrogen (N) content of the rumen fluid was determined using colorimetric method 14.…”

Section: Methodsmentioning

confidence: 99%

Responses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep

Al-Mamun¹,

Gotō²,

Chiba³

et al. 2009

Int. J. Biol. Sci.

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An isotope dilution method using [1-13 C]sodium (Na) acetate was conducted to determine the effect of feeding hop (Humulus lupulus L.) residues on plasma acetate metabolism in six adult crossbred sheep. The sheep were fed 63 g/kg BW 0.75 /d of either mixed hay (MH-diet) of orchardgrass (Dactylis glomerata L.) and reed canarygrass (Phalaris arundinacea L.) at a 60:40 ratio or MH-diet and hop-residues (Hop-diet) at 85:15 ratio with a crossover design for each of 3 week period. The isotope dilution method using single injection of [1-13 C]Na acetate was performed thrice; before feeding (BF), 2 h after feeding (2F) and 4 h after feeding (4F), on the 21 st day of each dietary treatment. Plasma acetate concentration tended to increase (P= 0.06) and turnover rate was numerically higher (P= 0.16) for MH-diet than Hop-diet. Plasma glucose, NEFA, VFA and lactic acid concentrations were similar between dietary treatments. In both the diets, although plasma concentration of acetate did not change, turnover rate increased significantly (P= 0.02) 2F than BF. Hop-residues did not show any negative impacts on acetate metabolism as well as physiology of animals in the present experimental conditions, hence thereby it could be used as an alternative to MH-diet for rearing sheep.

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Section: Methodsmentioning

confidence: 99%

Responses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep

Al-Mamun¹,

Gotō²,

Chiba³

et al. 2009

Int. J. Biol. Sci.

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“…Moreover, Cowan et al (2012) found positive response of addition of GLP-1 receptor agonist with Table 4 Effects of plantain (Plantago lanceolata L.) and heat exposure (30°C) on plasma glucose production (PGP) and utilization (PGU) rates and response of plasma glucose utilization (RPGU) to exogenous insulin infusion in sheep insulin in reducing insulin doses, further weight loss and risk of hypoglycemia in individuals having insulin resistance. Catalpol is one of the bioactive components of plantain (Al-Mamun et al, 2008a), which might be responsible for the insulin resistance. Because, the catalpol was found has the equal potentiality to work as like as GLP-1 receptor agonist (Jia et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…The experiment was performed using a crossover design with two 23-day periods in which either PL-or MH-diets were fed (Figure 1). Fresh plantain grown in the experimental field of Iwate University was cut and delivered daily (for details about the location and cultivation please see Al-Mamun et al, 2008a). The mixed hay and fresh plantain was chopped and fed to the animals in order to avoid choice feeding, as the morphology, such as leaves size, stems physical properties, can stimulate foraging behavior of sheep (Provenza, 2003;Smit et al, 2005;Barre et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

“…Plantain has anti-bacterial properties (Ishiguro et al, 1982), enzyme inhibitory activities (Nishibe and Murai, 1995) and anti-inflammatory effects (Park and Chang, 2004;Beara et al, 2010). Plantain also has bioactive components, acteoside, aucubin and catalpol (Al-Mamun et al, 2008a) that express superoxide anion radical scavenging activities (Al-Mamun et al, 2007a). It was reported that plantain had a positive influence on whole body protein synthesis (Al-Mamun et al, 2008b) in sheep during HE (30°C, 70% RH).…”

Section: Introductionmentioning

confidence: 99%

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Responses of plasma glucose metabolism to exogenous insulin infusion in sheep-fed forage herb plantain and exposed to heat

Al-Mamun

Shibuya

Kajita

et al. 2017

Animal

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The use of herbal plants as traditional medicines has a century long history. Plantain (Plantago lanceolata L.) is a perennial herb containing bioactive components with free radical scavenging activities. An isotope dilution technique using [U-13 C]glucose was conducted to determine the effect of plantain on the responses of plasma glucose metabolism to exogenous insulin infusion in sheep. Six crossbred sheep (three wethers and three ewes; mean initial BW = 40 ± 2 kg) were fed either a mixed hay of orchardgrass ( Dactylis glomerata) and reed canarygrass ( Phalaris arundinacea) (MH-diet) or mixed hay and fresh plantain (1 : 1 ratio, dry matter basis, PL-diet) and exposed to a thermoneutral (TN, 20°C; 70% relative humidity (RH)) environment or a heat exposure (HE, 30°C; 70% RH) for 5 days using a crossover design for two 23-day periods. The isotope dilution was conducted on days 18 and 23 of the experimental period during TN and HE, respectively. Plasma concentration of α-tocopherol was greater ( P < 0.0001) for the PL-diet than the MH-diet and remained comparable between environmental treatments. Plasma glucose concentration before isotope dilution technique was reduced for sheep ( P = 0.05) during HE compared with TN and remained comparable between diets. Plasma glucose turnover rate during the preinfusion period of insulin did not differ ( P = 0.10) between dietary treatments and between environments ( P = 0.65). The response of plasma glucose utilization to exogenous insulin administration was lower ( P = 0.04) for the PL-diet than the MH-diet. Under present experimental conditions, the plantain group was found to be resistant to the effects of insulin infusion.Keywords: glucose metabolism, plantain, insulin, heat stress, sheep Implications Plantain (Plantago lanceolata L.) is a perennial herb having bioactive components. The present experiment evaluated the effect of plantain on the responses of plasma glucose metabolism to exogenous insulin in heat-exposed sheep. Plasma glucose turnover rate (TR) was affected neither by feeding plantain nor exposure to a hot environment (30°C, 70% relative humidity (RH)). However, the response of plasma glucose utilization to exogenous insulin infusion was reduced in sheep when 50% of the mixed hay of orchardgrass (Dactylis glomerata) and reed canarygrass (Phalaris arundinacea) diet was replaced by fresh plantain.

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“…A wide array of environmental factors have been shown to influence the types or concentrations of specialized metabolites produced by the model Plantago species, including plant/leaf age and phenology (Barton, 2008;Hanley et al, 2013;Pankoke et al, 2013;Sutter & Muller, 2011), herbivore and pest damage (Bowers, Collinge, Gamble, & Schmitt, 1992;Sutter & Muller, 2011), genotype (Adler, Schmitt, & Bowers, 1995;Al-Mamun, Abe, Kofujita, Tamura, & Sano, 2008;Barton, 2007;Marak, Biere, & van Damme, 2002;Zubair et al, 2012), habitat type (Adler et al, 1995), plant competition (Barton & Bowers, 2006;Pankoke, Hopfner, Matuszak, Beyschlag, & Muller, 2015;Waschke, Hancock, Hilker, Obermaier, & Meiners, 2015), associations with microorganisms including arbuscular mycorrhizal fungi (Bennett & Bever, 2007;Bennett, Macrae, Moore, Caul, & Johnson, 2013;Fontana, Reichelt, Hempel, Gershenzon, & Unsicker, 2009;Schweiger et al, 2014;Wang, Bezemer, van der Putten, & Biere, 2015), nutrient levels (Darrow & Bowers, 1999;Jarzomski, Stamp, & Bowers, 2000;Miehe-Steier, Roscher, Reichelt, Gershenzon, & Unsicker, 2015;Pankoke et al, 2015), UV levels (McCloud & Berenbaum, 1999;Murai et al, 2009), and variation in geography and climate (Mølgaard, 1986;Murai et al, 2009;Pellissier, Roger, Bilat, & Rasmann, 2014;Reudler & Elzinga, 2015).…”

Section: Introductionmentioning

confidence: 99%

Untargeted metabolic profiling reveals geography as the strongest predictor of metabolic phenotypes of a cosmopolitan weed

Ahlstrand

Reghev

Markussen

et al. 2018

Ecology and Evolution

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Plants produce a multitude of metabolites that contribute to their fitness and survival and play a role in local adaptation to environmental conditions. The effects of environmental variation are particularly well studied within the genus Plantago; however, previous studies have largely focused on targeting specific metabolites. Studies exploring metabolome‐wide changes are lacking, and the effects of natural environmental variation and herbivory on the metabolomes of plants growing in situ remain unknown. An untargeted metabolomic approach using ultra‐high‐performance liquid chromatography–mass spectrometry, coupled with variation partitioning, general linear mixed modeling, and network analysis was used to detect differences in metabolic phenotypes of Plantago major in fifteen natural populations across Denmark. Geographic region, distance, habitat type, phenological stage, soil parameters, light levels, and leaf area were investigated for their relative contributions to explaining differences in foliar metabolomes. Herbivory effects were further investigated by comparing metabolomes from damaged and undamaged leaves from each plant. Geographic region explained the greatest number of significant metabolic differences. Soil pH had the second largest effect, followed by habitat and leaf area, while phenological stage had no effect. No evidence of the induction of metabolic features was found between leaves damaged by herbivores compared to undamaged leaves on the same plant. Differences in metabolic phenotypes explained by geographic factors are attributed to genotypic variation and/or unmeasured environmental factors that differ at the regional level in Denmark. A small number of specialized features in the metabolome may be involved in facilitating the success of a widespread species such as Plantago major into such wide range of environmental conditions, although overall resilience in the metabolome was found in response to environmental parameters tested. Untargeted metabolomic approaches have great potential to improve our understanding of how specialized plant metabolites respond to environmental change and assist in adaptation to local conditions.

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Comparison of the bioactive components of the ecotypes and cultivars of plantain (Plantago lanceolata L.) herbs

Cited by 20 publications

References 22 publications

Responses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep

Responses of Plasma Acetate Metabolism to Hop (Humulus lupulus L.) in Sheep

Responses of plasma glucose metabolism to exogenous insulin infusion in sheep-fed forage herb plantain and exposed to heat

Untargeted metabolic profiling reveals geography as the strongest predictor of metabolic phenotypes of a cosmopolitan weed

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