Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon

Jay, Gregory D.; Haberstroh, Karen M.; Cha, Chung-Ja

doi:10.1002/(sici)1097-4636(19980605)40:3<414::aid-jbm11>3.0.co;2-j

Cited by 131 publications

(123 citation statements)

References 25 publications

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“…These results were consistent with findings of several previous studies and extended them using native cartilage surfaces in similar (8,9) and different (10,11) test configurations, as well as using nonbiologic surfaces (8,12,13). The lubricating ability of HA has been assessed at cartilage-cartilage (14)(15)(16)(17)(18), cartilage-steel (19), and cartilage-glass interfaces (18,20), as well as at a latex-glass interface under boundary lubrication conditions (12,21), with variable conclusions, possibly due to the different test surfaces and configurations and the various resulting operative modes of lubrication. Conversely, PRG4 proteins (22), which are synthesized and secreted by cells lining the synovial cavity (4,5), have consistently demonstrated boundary-lubricating ability at both cartilage-glass (23) and latex-glass interfaces (12,21,24,25).…”

supporting

confidence: 92%

“…SF was recently shown to function as an effective boundary lubricant at an interface between apposed articular cartilage surfaces using an annulus-ondisc configuration (7). These results were consistent with findings of several previous studies and extended them using native cartilage surfaces in similar (8,9) and different (10,11) test configurations, as well as using nonbiologic surfaces (8,12,13). The lubricating ability of HA has been assessed at cartilage-cartilage (14)(15)(16)(17)(18), cartilage-steel (19), and cartilage-glass interfaces (18,20), as well as at a latex-glass interface under boundary lubrication conditions (12,21), with variable conclusions, possibly due to the different test surfaces and configurations and the various resulting operative modes of lubrication.…”

supporting

confidence: 89%

“…However, the absolute value of Ͻ kinetic, Neq Ͼ in 450 g/ml PRG4 observed here (ϳ0.10) ( Figure 4B) is slightly more than the range of values reported in several other studies by Jay et al (ϳ0.047-0.018 in 250-400 g/ml PRG4) (12,25,43). This difference may be due to the way in which PRG4 interacts with native articular cartilage surfaces, used in the present study, compared with other test surfaces.…”

Section: Discussioncontrasting

confidence: 59%

“…Similar SF constituents have been used in several previous studies examining their lubricating function (12,18,21,(23)(24)(25)(26), and future studies may examine the friction-lowering effects of other specific forms of SF constituents. Additional studies examining the structure-function relationship of SF constituents contributing to boundary lubrication, both alone and in combination, may provide the framework for the potential complete recapitulation of the boundary-lubricating ability of whole SF.…”

Section: Discussionmentioning

confidence: 99%

“…The lubricating ability of HA has been assessed at cartilage-cartilage (14)(15)(16)(17)(18), cartilage-steel (19), and cartilage-glass interfaces (18,20), as well as at a latex-glass interface under boundary lubrication conditions (12,21), with variable conclusions, possibly due to the different test surfaces and configurations and the various resulting operative modes of lubrication. Conversely, PRG4 proteins (22), which are synthesized and secreted by cells lining the synovial cavity (4,5), have consistently demonstrated boundary-lubricating ability at both cartilage-glass (23) and latex-glass interfaces (12,21,24,25). Studies examining the lubricating ability of SAPL at a cartilage-cartilage interface (in combination with HA) (19) and at a cartilage-steel interface (19,26), as well as at a latex-glass interface under boundary lubrication conditions (13), suggest that SAPL may also possess boundary-lubricating ability.…”

mentioning

confidence: 99%

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Boundary lubrication of articular cartilage: Role of synovial fluid constituents

Schmidt

Gastelum

Nguyen

et al. 2007

Arthritis & Rheumatism

480

510

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Objective. To determine whether the synovial fluid (SF) constituents hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPL) contribute to boundary lubrication, either independently or additively, at an articular cartilage-cartilage interface.Methods. Cartilage boundary lubrication tests were performed with fresh bovine osteochondral samples. Tests were performed using graded concentrations of SF, HA, and PRG4 alone, a physiologic concentration of SAPL, and various combinations of HA, PRG4, and SAPL at physiologic concentrations. Static ( static, Neq ) and kinetic (< kinetic, Neq >) friction coefficients were calculated.Results. Normal SF functioned as an effective boundary lubricant both at a concentration of 100% (< kinetic, Neq > ‫؍‬ 0.025) and at a 3-fold dilution (< kinetic, Neq > ‫؍‬ 0.029). Both HA and PRG4 contributed independently to a low in a dose-dependent manner. Values of < kinetic, Neq > decreased from ϳ0.24 in phosphate buffered saline to 0.12 in 3,300 g/ml HA and 0.11 in 450 g/ml PRG4. HA and PRG4 in combination lowered further at the high concentrations, attaining a < kinetic, Neq > value of 0.066. SAPL at 200 g/ml did not significantly lower , either independently or in combination with HA and PRG4. Conclusion. The results described here indicate that SF constituents contribute, individually and in combination, both at physiologic and pathophysiologic concentrations, to the boundary lubrication of apposing articular cartilage surfaces. These results provide insight into the nature of the boundary lubrication of articular cartilage by SF and its constituents. They therefore provide insight regarding both the homeostatic maintenance of healthy joints and pathogenic processes in arthritic disease.

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supporting

confidence: 92%

supporting

confidence: 89%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Boundary lubrication of articular cartilage: Role of synovial fluid constituents

Schmidt

Gastelum

Nguyen

et al. 2007

Arthritis & Rheumatism

480

510

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Lubrication and Wear Protection of Natural (Bio)Systems

Greene¹,

Lee²,

Yu³

et al. 2013

Polymer Adhesion, Friction, and Lubrication

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Investigation of Superlubricity Achieved by Polyalkylene Glycol Aqueous Solutions

Wang

Liu

2016

Adv Materials Inter

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and investigated the fl uidity of hydration layers [26][27][28] to better understand the frictional behaviors in biological systems. Previously, our group reported different kinds of liquid superlubricity, e.g., boric acid with glycerol, [ 29 ] phosphoric acid, [ 30 ] as well as glycerol, [ 31 ] polyhydroxy alcohol solutions, [ 32 ] ethylene glycol, [ 33 ] and silicone oil [ 34 ] by running-in with an acid solution. However, the widespread application of these lubricating fl uids in industry is limited by the production of hydrogen ions and the high dependence on water content in these systems.Polyalkylene glycols (PAGs), a type of synthetic lubricants, are the copolymers from any combination of different alkylene oxides, typically of ethylene oxide (EO) and propylene oxide (PO). [ 35 ] Their high-temperature stability, low pour point, and high viscosity index are highly suited for the normal operation of mechanical equipment, for example, ore crushers, cement kilns, and steel roller bearings. In addition, most PAGs are biodegradable and some of them are even food-grade accredited, which means they satisfy the demands necessary for application in the agriculture, forestry, mining, and food-manufacturing industries. [ 35,36 ] By controlling the mixing ratio of EO/PO, the chemical structure of PAG allows for high-strength hydrogen bonding; thus, the solubility of PAG will be adjusted accordingly. [35][36][37] The presence of oxygen atoms in the polymer backbone results in the highly polar PAG being able to absorb onto the contact surface. As such, they have been widely applied in the textile industry, for household cleaners and polishes, and metal cutting. [ 36,38 ] In present work, considering that PAGs have a good hydration and adsorption capacity, we investigated the tribological properties of these aqueous solutions. Using various weight fractions of PAG, the friction coeffi cient was recorded in both droplet and full immersion states. As a result, ultralow friction coeffi cient can be achieved using a wide range of concentration. The contact region after test and the hydration state of PAG chains were analyzed to determine the mechanism of the superlubricity phenomenon in this system. Because of its superior lubrication property and the stable state of the system under ambient conditions, the application of this environmentally friendly solution, such as bearing and joint lubricating systems, was proposed to save energy via the reduction of friction, and prevent pollution from lubricant leakage.Ultralow friction coeffi cient ( µ ) of a polyalkylene glycol (PAG) aqueous solution obtained in both droplet state (40 µL) and full immersion state after a running-in period. Here, two key factors in achieving the superlubricity state ( µ < 0.01) demonstrated: the low shearing strength of the hydrated layer and the presence of a suitable amount of free water molecules. In the initial running-in period, a decrease in contact pressure contributes to the formation of elastohydrodynamic behavior of fl uid. The hydrogen-bon...

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Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon

Cited by 131 publications

References 25 publications

Boundary lubrication of articular cartilage: Role of synovial fluid constituents

Boundary lubrication of articular cartilage: Role of synovial fluid constituents

Lubrication and Wear Protection of Natural (Bio)Systems

Investigation of Superlubricity Achieved by Polyalkylene Glycol Aqueous Solutions

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