Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases

Abstract

Objective: To investigate the clinicopathologic correlation of the glomerular diseases and to compare the presentations of primary and secondary glomerular diseases. Methods: Two hundred and sixty adult patients (men = 56.2%, mean age = 39.9 ± 16.0 years) who had undergone renal biopsy and been diagnosed with glomerular disease were retrospectively investigated. The information about the demographic and clinical characteristics of the patients, the indications for biopsy, the laboratory parameters, and the pathological results of the biopsies were obtained from the medical records. Primary and secondary glomerulonephritis (GN) groups were compared in terms of their demographic characteristics, indications for biopsy, and laboratory parameters. Results: Percent of patients with primary and secondary GN were 63.5% and 36.5%, respectively. The most common indication for biopsy was nephrotic syndrome (53.8%) in all patients. It was found that presentation with impaired renal function was more prevalent in the secondary GN group when compared with the primary GN group (54.7% vs. 35.8%, p < 0.05). Among the inflammation parameters, the levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be significantly higher in the secondary GN group when compared with the primary GN group (ESR = 85.2 ± 30.4 mm/h vs. 56.3 ± 30.7 mm/h, p < 0.001; CRP = 42.1 ± 39.6 mg/L vs. 21.7 ± 40.2 mg/L, p < 0.001). Conclusions: The clinicopathologic correlation of GN was found similar with the larger studies in the literature. This study also indicated that the rate of patients with secondary GN was not low, and the inflammation parameters were higher in the secondary GN groups.

Capillaroscopic changes in patients with glomerular diseases: a case control study

“…Primary glomerulonephritis patients had higher median values of 24-hour urinary protein than lupus nephritis patients and this was similar to the results of a previous study (27). On contrary, another study did not nd statistically signi cant difference between primary GN and lupus nephritis as regard urinary protein levels (26).…”

“…In the present study, there were no statistically signi cant age and sex differences between primary glomerulonephritis and lupus nephritis patients. In agreement with this, two other studies reported similar results (26) (27). On contrary, marked female preponderance was noted for lupus nephritis and thin basement membrane nephropathy, whereas a modest male predominance was noted for acute postinfectious GN, FSGS and IgA nephropathy (28).…”

Comparative analysis of primary and secondary glomerulopathies in the northeast of Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG

“…22 The worsening of renal function and the presence of hematuria were also related to secondary etiology in the final model of this study. In fact, Kutlugun et al 22 demonstrated that renal dysfunction (creatinine > 1.5 mg/dl) was significantly more related to SG.…”

“…On the other hand, Ferraz et al 7 and Kutlugun et al 22 found no gender differences among the etiologies. However, in the latter study there was a high prevalence of AA amyloidosis (43%) as a secondary cause, which may have been responsible for this difference in the results.…”

Study of Clinical and Immunological Associations of Primary Glomerulonephritis

“…ХБП [1,2]. ГН подразделяются на первичные и вторичные [3]. Выделяют 4 варианта клинического течения первичного ГН -нефротический, гипертонический, смешанный и латентный.…”