Comparison of the Clinical Effectiveness of Intra-Articular Injection with Different Substances After TMJ Arthroscopy: A Systematic Review and Meta-Analysis

Abstract

Objective This systematic review aims to describe the clinical outcomes after TMJ arthroscopy followed by intra articular infiltration with different substances. Materials and Methods A literature search was carried out, the variables were Arthroscopy with different substances, pain and maximal mouth opening. The inclusion criteria were articles that reported infiltration of different substances after arthroscopy. Case series, observational studies, and randomized clinical trials were included. Exclusion criteria were studies that included arthrocentesis, animal studies, connective tissue disease, patients with previous surgeries. Results Of the 5 studies finally included, the population studied were 346 subjects, of which 315 were female. The mean age was 34.7 (16–77). Regarding diagnoses, Wilkes III and Wilkes IV were taken into account. The most commonly used substance was sodium hyaluronate/hyaluronic acid in 4 of the 5 studies. Conclusion Multiple substances have been infiltrated within the temporomandibular joint, with sodium hyaluronate/hyaluronic acid being the most studied. However, the benefit of substances like ATM artroscopia adyuvantes has not been clearly established. It is recommended in future studies that the substances and results be evaluated in the same way to obtain more homogeneous studies.

Temporomandibular Disorders Management—What’s New? A Scoping Review

“…Pharmacological agents commonly employed in TMD treatments encompass NSAIDs, opioids, CCS, muscle relaxants, antidepressants, anticonvulsants, and benzodiazepines [ 28 , 47 , 62 , 69 , 82 , 84 , 85 , 98 , 99 , 100 , 101 , 102 ]. Regarding pain management in TMDs, some evidence suggests that NSAIDs can be considered as an initial approach for alleviating joint and muscle pain in TMD patients [ 99 , 100 ].…”

Equine Models of Temporomandibular Joint Osteoarthritis: A Review of Feasibility, Biomarkers, and Molecular Signaling

“…Similar bone changes can be observed on CT images in both humans [ 51 , 63 ] and horses [ 6 , 7 , 41 , 59 ]. Cartilage defects can be visualized using arthroscopy, more often in horses [ 34 , 59 , 64 ] than in humans [ 65 ], and MRI, on the contrary, more often in humans [ 49 , 60 , 66 , 67 , 68 ] than in horses [ 62 , 69 ].…”

“…Although biomarkers can be measured from other specimens, such as blood or urine, their levels are influenced by other diseases or metabolic conditions. This limitation is also recognized in human clinical studies [ 33 , 49 , 51 , 65 , 66 ]. Therefore, every effort should be made to establish more and more biomarkers in the equine TMJ OA model.…”