Comparison of the Clinical Efficacy of Salbutamol with Jet and Mesh Nebulizers in Asthmatic Children

Murayama, Norihide; Murayama, Kikuno

doi:10.1155/2018/1648652

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…For the children younger than 2 years, the heart rate increment was not significant. They concluded that the dose of salbutamol solution might be excessive for the older age group [10]. In our study, adverse effects were similar in both nebulizers, but the complaint of palpitation was significantly higher in the MN group.…”

Section: Discussionsupporting

confidence: 49%

“…Although some differences in lung function improvement had been detected, all 3 mesh nebulizers were found to be useful devices in treating bronchial asthma [9]. A clinical [10]. We did not compare the inhalation time, but we observed similar degrees of improvement in lung functions after beta 2 - agonist inhalation in both groups.…”

Section: Discussionmentioning

confidence: 72%

“…They found no significant difference between clinical scores with 2 devices. Similarly, shortened inhalation time with MN was shown[10]. We did not compare the inhalation time, but we observed similar degrees of improvement in lung functions after beta 2 -…”

mentioning

confidence: 62%

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Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Soyer¹,

Kahveci²,

Büyüktiryaki³

et al. 2019

Turk J Med Sci

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Background/aim: The aim of this study was to compare the effect of salbutamol delivered to children by jet nebulizer (JN) and mesh nebulizer (MN). Materials and methods:Children admitted with acute asthma were treated with 3 doses of nebulized salbutamol, 1 given by MN. The patients' vital signs, lung function measurements, modified pulmonary index score (MPIS), and whole body plethysmography (WBP) measurements were evaluated before and 20 min after each dose of salbutamol.Results: Thirty-one children [9.5 (6.4-17.2) years, 67.7% male, 32.3% female] with mild (67.7%) and moderate (32.3%) asthma attacks were included in the study. The improvements with MN were comparable with JN in terms of changes in pretreatment and posttreatment forced expiratory volume in the first second (FEV1) (2.57 ± 4.57, 3.65 ± 5.44; P = 0.44), forced vital capacity (FVC) (2.52 ± 5.29, 4.17 ± 7.54; P = 0.28), heart rate (7.33 ± 10.21, 4.14 ± 9.32; P = 0.24), peripheral capillary oxygen saturation (SpO 2 ) (0.38 ± 0.23, 0.43 ± 0.15; P = 0.83), and modified pulmonary index score (MPIS) (−6.30 ± 22.70, −8.77 ± 25.46; P = 0.70). The pre-and posttreatment values of total lung capacity (TLC), residual volume (RV), specific conductance (sGaw), and RV/TLC were similar for the JN and MN groups. Adverse effects were not different: however, complaints of palpitation were significantly higher in the posttreatment MN group than the pretreatment MN group (32.3% vs 9.7%, respectively, P = 0.016). Conclusions:These findings support the previous evidence found in studies of adults that MN is as effective as and as safe as JN in the treatment of acute asthma in children.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 72%

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Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Soyer¹,

Kahveci²,

Büyüktiryaki³

et al. 2019

Turk J Med Sci

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“…However, comparative studies on salbutamol delivery efficiency in various types of nebulizers have mostly been based on the use of a breathing simulator with mechanical ventilation, a humidifier, and breathing masks [14,16]. A few clinical studies have compared the efficacy, admission rates, and total dose of salbutamol used by jet and mesh nebulizers in asthmatic children and emergency rooms [20,21].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice

Chang

Moon

et al. 2019

Pharmaceutics

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Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.

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“…For example, nebulization products for chronic and rare diseases are available on the market for coupling with a dedicated tested nebulizer [15,16,17,18]. In fact, variability in dose delivery from different nebulizers has been reported [8,19,20,21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

et al. 2019

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In this work, 13 jet nebulizers, some of which in different configurations, were investigated in order to identify the biopharmaceutical constraints related to the quality attributes of the medicinal products, which affect their safety, efficiency, compliance, and effectiveness. The aerosolization parameters, including the aerosol output, aerosol output rate, mass median aerodynamic diameter, and fine particle fraction, were determined according to the European Standard EN 13544-1, using sodium fluoride as a reference formulation. A comparison between the aerosol output nebulization time and the fine particle fraction displayed a correlation between the aerosol quality and the nebulization rate. Indeed, the quality of the nebulization significantly increased when the rate of aerosol emission was reduced. Moreover, the performance of the nebulizers was analyzed in terms of respirable delivered dose and respirable dose delivery rate, which characterize nebulization as the rate and amount of respirable product that could be deposited into the lungs. Depending on which of these two latter parameters was used, the nebulizers showed different performances. The differences, in terms of the rate and amount of delivered aerosol, could provide relevant information for the appropriate choice of nebulizer as a function of drug product, therapy, and patient characteristics.

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Comparison of the Clinical Efficacy of Salbutamol with Jet and Mesh Nebulizers in Asthmatic Children

Cited by 9 publications

References 7 publications

Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Mesh nebulizer is as effective as jet nebulizer in clinical practice of acute asthma in children

Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

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