Comparison of the Combined Marker Ggt–cdt and the Conventional Laboratory Markers of Alcohol Abuse in Heavy Drinkers, Moderate Drinkers and Abstainers

Hietala, Johanna; Koivisto, Heidi; Anttila, Petra; Niemelä, Onni

doi:10.1093/alcalc/agl050

Cited by 123 publications

(80 citation statements)

References 30 publications

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“…Also, EtG has recently been suggested as a marker of chronic high alcohol intake, measured in hair (64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76). According to the research so far, the sensitivity and specificity exceeds that of the traditional markers for chronic high alcohol intake, like the liver enzymes aspartate aminotranserase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) as well as carbohydratedeficient transferrin (CDT) (34,35,(77)(78)(79)(80).…”

Section: Non-oxidative Metabolism Of Ethanol; Ethyl Glucuronide and Ementioning

confidence: 99%

A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol

Høiseth¹,

Karinen²,

Christophersen³

et al. 2007

Forensic Science International

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Section: Non-oxidative Metabolism Of Ethanol; Ethyl Glucuronide and Ementioning

confidence: 99%

A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol

Høiseth¹,

Karinen²,

Christophersen³

et al. 2007

Forensic Science International

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“…Such circumstances led us to not use a quantity-frequency survey for detecting hazardous drinking but instead to use the total AUDIT (Alcohol Use Disorders Identification Test) score and/or %CDT. The main reasons for choosing these tools were as follows: a) several research papers have shown that the AUDIT is the most effective tool for identifying subjects with hazardous levels of drinking 23) , and b) although alcohol consumption continues to rise in most developed countries, those subject to hazardous drinking escape clinical diagnosis, so it is widely accepted that biochemical markers are useful for sensitive and effective detection of real alcohol consumption 24) , with %CDT being the only marker test approved by the FDA for the identification of hazardous drinking 25) . In our study, the proportion of workers that were screened as positive for one or both of the AUDIT and CDT tests was 13.8%.…”

Section: Discussionmentioning

confidence: 99%

Screening for Hazardous Drinking in Migrant Workers in Southeastern Spain

Pérez-Cárceles

Medina

Pérez‐Flores

et al. 2014

Journal of Occupational Health

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Screening for Hazardous Drinking in Migrant Workers in Southeastern Spain : Maria D. PEREZ‐CARCELES, et al. Department of Health and Social Sciences, Regional Campus of International Excellence “Campus Mare Nostrum”, School of Medicine, University of Murcia, E30100, Spain— Objectives Despite the great impact the migration has had in economic, social and health‐related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem by means of a self‐reported questionnaire (Alcohol Use Disorders Identification Test‐AUDIT) and a biomarker (carbohydrate‐deficient transferrin‐CDT) and to ascertain associated risk factors. Methods A cross‐sectional survey was conducted using a random sample of 385 migrant workers, undergoing a routine health examination as part of occupational health services. Results The results showed that 13.8% (n=53) of the workers were screened as positive with the AUDIT (≥8) and/or CDT (>2.6) and identified as hazardous drinkers and that 53.8% (n=207) were teetotallers. Being a man (OR: 2.0), working in the construction industry (OR: 2.8) or agriculture (OR: 2.2), being resident in Spain for more than 7 years (OR: 2.3) and sharing a house with friends were the factors most closely associated with hazardous drinking. Conclusions Prevention‐orientated programs, adjusted to the characteristics of each country and the origin of the migrants themselves, should be instituted to modify the drinking habits of migrant workers considered at risk.

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“…New biomarkers that have high specificity and sensitivity are increasingly being used today. One of them is CDT, the first test to be approved in the USA by the FDA (Food and Drug Administration) as the biomarker for alcoholism (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate-Deficient Transferrin - A Contemporary Biomarker in Comparison with Traditional Laboratory Markers of Chronic Alcohol Abuse

Maksić¹,

Vodnik²,

Stanković³

et al. 2010

Journal of Medical Biochemistry

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Summary: Timely identification of excessive alcohol use and its potential complications is a prerequisite for successful treatment. Several routine tests have been used in laboratories that may help in diagnosing alcoholism, such as determination of MCV, AST, ALT, GGT, but it has been shown that they lack specificity and sensitivity. Contemporary biomarkers are increasingly being used today that may due to their unique characteristics help in disco vering the onset of chronic alcohol abuse, as well as in abstinence and relapse monitoring. The term carbohydrate-deficient transferrin (CDT) stands for a small group of human transferrin isoforms (asialo, monosialo, and disialotran sferrin) with a lower degree of glycosylation in comparison to the dominant transferrin isoform (tetrasialotransferrin). Persons consuming large quantities of alcohol (≥50 -80 g daily) over a period of at least two weeks have increased concentrations of transferrin isoforms lacking one (disialo transferrin) or both (asialotransferrin) carbohydrate chains. In this paper the traditional markers of chronic alcohol abuse (GGT, AST, ALT, and MCV) were determined, as well as the new biomarker CDT, after which diagnostic evaluation was performed and their usability and clinical value in routine laboratory practice were estimated. These markers were also determined in heavy alcoholics on admission into hospital and after two weeks of therapy, with the aim of estimating their diagnostic value for abstinence and relapse monitoring. Keywords: alcoholism, biomarkers, CDT, transferrinKratak sadr`aj: Pravovremeno prepoznavanje preko merne upotrebe alkohola i potencijalnih komplika cija pred uslov je za uspe{no le~enje. U laboratorijama se koristi neko liko rutinskih testova koji mogu da pomognu u dijagnostici alkoholizma, kao npr. odre|ivanje MCV, AST, ALT, GGT, ali su se pokazali kao nedovoljno specifi~ni i osetljivi. Danas su sve vi{e u upotrebi savremeni biomarkeri koji zahvaljuju}i svojim jedin stvenim osobinama mogu da pomognu kod otkrivanja po ja ve hroni~nog alkoholizma, kao i pri pra}enju apstinencije i relapsa. Naziv transferin deficijentan ugljenim hidratima (CDT) podrazumeva manju grupu izoformi humanog trans ferina (asialo-, monosialo-i disialo-transferin), koje imaju ni`i stepen glikozilacije u pore|enju sa do minantnom izo for mom transferina (tetrasialotran sfe rin). Osobe koje unose velike koli~ine alkohola (≥50-80 g dnevno) u periodu od najmanje 2 nedelje imaju povi{ene koncentracije izoformi transferina kojima nedostaje jedan (disialotransferin) ili oba (asialotransferin) ugljeno hidratna lanca. U ovom radu oba vlje no je odre|ivanje tradicionalnih marke ra hroni~ne alko ho lne potro{nje (GGT, AST, ALT i MCV), kao i novog bio markera CDT, a zatim je izvr{ena dijagno sti~ka evaluacija i procena njihove upotrebljivosti i klini~ke vrednosti u rutin skoj laboratorijskoj praksi. Tako|e je izvr{eno odre|ivanje navedenih markera kod te{kih alkoholi~ara pri prijemu na bolni~ko odeljenje i nakon 2 nedelje terapije u cilju proce ne njihove dijag...

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Comparison of the Combined Marker Ggt–cdt and the Conventional Laboratory Markers of Alcohol Abuse in Heavy Drinkers, Moderate Drinkers and Abstainers

Abstract: GGT-CDT improves the sensitivity of detecting excessive ethanol consumption as compared with the traditional markers of ethanol consumption. These findings should be considered in the assessment of patients with alcohol use disorders.

Cited by 123 publications

References 30 publications

A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol

A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol

Screening for Hazardous Drinking in Migrant Workers in Southeastern Spain

Carbohydrate-Deficient Transferrin - A Contemporary Biomarker in Comparison with Traditional Laboratory Markers of Chronic Alcohol Abuse

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