Comparison of the concentration of trace metals (Ni, Zn, Co, Cu and Se), Fe, vitamins A, C and E, and lipid peroxidation in patients with prostate cancer

Özmen, Habibe; Erulaş, Fatih Ahmet; Karataş, Fikret; Çukurovalı, Alaaddin; Yalçın, Orhan

doi:10.1515/cclm.2006.032

Cited by 59 publications

(43 citation statements)

References 21 publications

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“…This agrees with the work done by other researchers. 15,16 Decrease in vitamin A, C and E could be as a result of inadequate dietary intake of fruits containing these antioxidant vitamins. It may also be related to the possibility that vitamin C and E reacts very rapidly with molecular oxygen and free radicals generated during prostate carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Onyema-iloh

Meludu

Iloh³

et al. 2014

Asian J Med Sci

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Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients. Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography. Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively. Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient.

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Section: Discussionmentioning

confidence: 99%

Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Onyema-iloh

Meludu

Iloh³

et al. 2014

Asian J Med Sci

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show abstract

“…In literature, significantly low serum level of Se had been detected in patients with prostate cancer [40,41]. In addition, the report by Clark et al state that oral selenium supplementation significantly lowers incidence of lung, colorectal and prostate cancer [42].…”

Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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“…inverse relationship exists between serum ascorbic acid concentrations and risk of cardiovascular disease [4,5] , diabetes [6,7] , some forms of cancer [8] and all-cause mortality [9] .…”

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confidence: 99%

Vitamin C Transporter Gene Polymorphisms, Dietary Vitamin C and Serum Ascorbic Acid

Cahill

El-Sohemy²

2009

Lifestyle Genomics

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Background/Aims: Vitamin C transporter proteins SVCT1 and SVCT2 are required for the absorption and transport of vitamin C in humans. This study aims to determine whether common SVCT genotypes modify the association between dietary vitamin C and serum ascorbic acid. Methods: Non-smoking men and women (n = 1,046) aged 20–29 were participants of the Toronto Nutrigenomics and Health Study. Overnight fasting blood samples were collected to determine serum ascorbic acid concentrations by HPLC and to genotype for two SVCT1 (rs4257763 and rs6596473) and two SVCT2 (rs6139591 and rs2681116) polymorphisms. Results: No diet-gene interactions were observed for the vitamin C transporter polymorphisms, however, the average (mean ± SE) serum ascorbic acid concentrations differed between rs4257763 genotypes (GG: 24.4 ± 1.3, GA: 26.8 ± 1.1, AA: 29.7 ± 1.4 µmol/l; p = 0.002). For this polymorphism, the correlation between dietary vitamin C and serum ascorbic acid was only significant in subjects with a G allele. The SVCT2 polymorphisms also appeared to modify the strength of the diet-serum correlation. Conclusions: Our findings demonstrate that genetic variation in SVCT1 can influence serum ascorbic acid concentrations and that SVCT1 and SVCT2 genotypes modify the strength of the correlation between dietary vitamin C and serum ascorbic acid.

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Comparison of the concentration of trace metals (Ni, Zn, Co, Cu and Se), Fe, vitamins A, C and E, and lipid peroxidation in patients with prostate cancer

Cited by 59 publications

References 21 publications

Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Vitamin C Transporter Gene Polymorphisms, Dietary Vitamin C and Serum Ascorbic Acid

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