Comparison of the COVID-2019 (SARS-CoV-2) Pathogenesis With SARS-CoV and MERS-CoV Infections

Fani, Mona; Teimoori, Ali; Ghafari, Shokouh

doi:10.2217/fvl-2020-0050

Cited by 113 publications

(126 citation statements)

References 30 publications

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“…Similar to the severe acute respiratory syndrome or SARS and Middle East respiratory syndrome or MERS, coronavirus disease 2019 or COVID-19 is a pandemic that has caused fear and uncertainty across continents [8][9][10]. Different from SARS and MERS, COVID-19 has greater transmissibility [11][12][13]. This, in turn, fuels its adverse impacts on societies at large as it leaves little time for governments across the world to develop an effective plan to tackle the pandemic.…”

Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

“…This, in turn, fuels its adverse impacts on societies at large as it leaves little time for governments across the world to develop an effective plan to tackle the pandemic. While SARS, MERS, and COVID-19 share similar virus characteristics [11][12][13], the epidemiological attributes of COVID-19 make it more di cult to contain and control as the virus evolves [11][12][13], further allowing it to continue wreaking havoc across the globe.…”

Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

“…Researchers found that educator-led programs based on the Health Belief Model yielded signi cantly more positive behavioral outcomes for females living with HIV when compared to standard talk therapy [81]. One way to determine potentially effective interventions for women during COVID-19 is to systematically review literature in the context of infectious disease pandemics [80,82,83] as they share attributes such as unpredictability (e.g., when, where, and how the crises unfold and fade) and destructiveness (e.g., uprooted lives and livelihoods) [11][12][13]. Communicable disease pandemics often share similar disaster preparedness procedures as well, like social distancing measures [84][85][86][87].…”

Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

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Evidence-based health solutions for challenges women face during pandemics like COVID-19: A systematic review protocol

Wagers

Lopez

et al. 2020

Preprint

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Background One of the most vulnerable populations to COVID-19 is women. Multiple factors associated with violence against women (i.e. sexual assault, domestic violence, homelessness) create an increased vulnerability for women during the COVID pandemic. Women also constitute the majority of older nursing home residents and healthcare workers (e.g., nurses), who have the most pronounced exposure to COVID-19. These factors combined with resource restraints like rationing and lack of access to healthcare can further exacerbate women’s physical and psychological health issues. While literature has well-documented challenges that women face during COVID-19, there is a lack of evidence-based solutions that have the potential to mitigate these difficulties. Therefore, to address this issue, we aim to conduct a systematic review of the literature to: (1) identify interventions designed for women in the context of pandemics, (2) describe the characteristics and effects of these interventions concerning the distinctive traits of women and pandemics, and (3) present evidence-based health solutions for women to mitigate challenges they face amid and beyond COVID-19. Methods A systematic review of literature will be conducted on databases including PubMed, PsycINFO on the EBSCO platform, CINAHL on the EBSCO platform, and Scopus, based on a search strategy developed in consultation with an experienced medical librarian. Titles, abstracts, and full-text articles will be screened against eligibility criteria developed a priori. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses procedures will be adopted as the reporting framework, and data extracted (e.g., intervention details) will be evaluated by a multidisciplinary research team. Results NA for now—This is a protocol study. Conclusions Findings of this study will fill an important void in the literature. Considering that, in times of pandemic, women are especially subject to grim health disparities, like pronounced exposure to COVID-19, reproductive health issues, elevated domestic violence, increased mental health challenges, and lack of access to healthcare services, the need for evidence-based health solutions that could address these unique challenges is of paramount importance. A comprehensive understanding of the characteristics and effects of health solutions available to women in the context of pandemics can also help researchers identify areas of improvement regarding intervention design and development. This may further safeguard women’s health and wellbeing amid pandemics like COVID-19 and beyond. Study Protocol Registration: PROSPERO CRD42020194003

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Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

Section: Study Protocol Registration: Prospero Crd42020194003mentioning

confidence: 99%

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Evidence-based health solutions for challenges women face during pandemics like COVID-19: A systematic review protocol

Wagers

Lopez

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Currently, severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic, which causes coronavirus disease (COVID- 19), was reported in Wuhan, China [1].…”

Section: Introductionmentioning

confidence: 99%

Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics

Fani

Zandi

Soltani

et al. 2020

Biotech and App Biochem

Self Cite

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According to the evidence, the coronavirus disease 19 (COVID-19) is caused by a zoonotic pathogen named respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can spread through personal contact, respiratory droplets, and also through airborne transmission. A rapid, low-cost, and effective biosensor platform is essential to diagnose patients with COVID-19 infection, predominantly the asymptomatic individuals, and prevent the spread of the SARS-CoV-2 via transmission routes. The objective of this review is to provide a comparative view among current diagnostic methods, focusing on recently suggested biosensors for the detection of SARS-CoV2 in clinical samples. A capable SARS-CoV-2 biosensor can be designed by the holistic insights of various biosensor studies.

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“…SARS-CoV-2 has an affinity that is comparable to SARS-CoV and MERS-CoV in binding to ACE-2. 16,17 Interaction at the active site of ACE-2 can explain part of the efficient transmission of SARS-CoV-2 in humans, as occurs in SARS-CoV and MERS-CoV. 18,19 Efforts to prevent the attachment of SARS-CoV-2 spike glycoproteins to ACE-2 will be able to control COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Fakih

Dewi

2020

J. Biomed. Transl. Res.

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Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals. SARS-CoV-2 uses ACE2 to enter cells with an affinity similar to SARS-CoV, correlated with the efficient spread of SARS-CoV-2 among humans.Objective: In the research, identification, evaluation, and exploration of the structure of SARS-CoV and SARS-CoV-2 spike glycoprotein macromolecules and their effects on Angiotensin-Converting Enzyme 2 (ACE-2) using in silico studies.Methods: The spike glycoproteins of the two coronaviruses were prepared using the BIOVIA Discovery Studio 2020. Further identification of the three-dimensional structure and sequencing of the macromolecular spike glycoprotein structure using Chimera 1.14 and Notepad++. To ensure the affinity and molecular interactions between the SARS-CoV and SARS-CoV-2 spike glycoproteins against ACE-2 protein-protein docking simulations using PatchDock was accomplished. The results of the simulations were verified using the BIOVIA Discovery Studio 2020.Results: Based on the results of the identification of the macromolecular structure of the spike glycoprotein, it was found that there are some similarities in characteristics between SARS-CoV and SARS-CoV-2. Protein-protein docking simulations resulted that SARS-COV-2 spike glycoprotein has the strongest bond with ACE-2, with an ACE score of −1509.13 kJ/mol.Conclusion: Therefore, some information obtained from the results of this research can be used as a reference in the development of SARS-CoV-2 spike glycoprotein inhibitor candidates for the treatment of infectious diseases of COVID-19.

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Comparison of the COVID-2019 (SARS-CoV-2) Pathogenesis With SARS-CoV and MERS-CoV Infections

Cited by 113 publications

References 30 publications

Evidence-based health solutions for challenges women face during pandemics like COVID-19: A systematic review protocol

Evidence-based health solutions for challenges women face during pandemics like COVID-19: A systematic review protocol

Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

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