Comparison of the cytotoxicity of clinically relevant cobalt–chromium and alumina ceramic wear particles in vitro

Germain, Marguerite; Hatton, Aurélie; Williams, Sophie; Matthews, J.B.; Stone, Martin; Fisher, John; Ingham, Eileen

doi:10.1016/s0142-9612(02)00360-5

Cited by 216 publications

(140 citation statements)

References 29 publications

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“…In order to assess possible cytotoxicity activity of UHMWPE/MWCNT wear particles, the present study used clinically relevant sterile wear debris, which was generated by articulation under aseptic conditions. In a similar study, Germain et al [35] demonstrated that clinically relevant cobalt-chromium particles reduced the viability of L929 cells at concentrations of 50µm 3 and 5 µm 3 per cell. In the present study, clinically relevant UHMWPE/MWCNT wear particles were shown not to have any adverse effect on L929 fibroblast cells in culture at any of the concentrations tested over time.…”

Section: Discussionmentioning

confidence: 86%

Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements

Suñer

Bladen

Gowland

et al. 2014

Wear

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Ultra high molecular weight polyethylene (UHMWPE) has been extensively used as a bearing surface in joint prostheses. However, wear debris generated from this material has been associated with osteolysis and implant loosening. Alternative materials, such as polymer composites, have been investigated due to their exceptional mechanical properties. The goal of the present work was to investigate the wear rate, size and volume distributions, bioactivity and biocompatibility of the wear debris generated from a UHMWPE/Multi-walled carbon nanotube (MWCNT) nanocomposite material compared with conventional UHMWPE. The results showed that the addition of MWCNTs led to a significant reduction in wear rate.Specific biological activity and functional biological activity predictions showed that wear particles from the UHMWPE/MWCNT nanocomposite had a reduced osteolytic potential compared to those produced from the conventional polyethylene. In addition, clinically relevant UHMWPE/MWCNT wear particles did not show any adverse effects on the L929 fibroblast cell viability at any of the concentrations tested over time. These findings suggest that UHMWPE/MWCNT nanocomposites represent an attractive alternative for orthopaedic applications.

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Section: Discussionmentioning

confidence: 86%

Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements

Suñer

Bladen

Gowland

et al. 2014

Wear

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“…However, there have been increasing concerns regarding the long-term durability of the joint replacement due to the generation of nano-sized particles and the release of toxic metal ions [1][2][3]. It has been recognized that tribocorrosion plays a very important role in degradation of CoCrMo alloys in biological environments, due to the synergistic effects between wear and corrosion [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Tribocorrosion Behavior of Duplex S/Cr(N) and S/Cr(C) Coatings on CoCrMo Alloy in 0.89 % NaCl Solution

Sun

Dearnley

2014

J Bio Tribo Corros

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In the present study, magnetron sputtering was used to deposit two types of duplex coatings, S/Cr(N) and S/Cr(C), onto ASTM F75 CoCrMo cast alloy, aiming at improving the tribocorrosion behavior of the medical alloy. The duplex coatings were fabricated and structured such that the inner layer comprised carbon S phase with a CoCrMo matrix by sputtering a CoCrMo alloy target in the presence of carbon containing atmosphere. The duplex coatings were found to be elastically compatible with the CoCrMo alloy, and possess higher hardness and a larger hardness-to-modulus ratio than the uncoated alloy. Tribocorrosion tests were conducted in 0.89 % NaCl solution at 37°C under elastic contact and unidirectional sliding conditions. The results showed that the duplex S/Cr(N) coating was very effective in improving the tribocorrosion behavior of the alloy at all applied potentials, in terms of reduced friction and much improved resistance to total material loss (TML) by up to more than one order of magnitude. On the other hand, the duplex S/Cr(C) coating was effective only at open circuit and anodic potentials (APs), but not at cathodic potentials. The uncoated alloy exhibited low friction and low TML at a large cathodic potential and experienced peculiar frictional behavior at the tested AP. The results are discussed in terms of material transfer, hydrogen charging, third body effects, and synergism between wear and corrosion.

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“…Nano-sized particles, ranging from 25 to 50 nm [9] for MOM bearings, could be phagocytosed and/ or pinocytosed more readily than microparticles and cause more mitochondrial and DNA damage [10]. Metal particles have been shown to be more cytotoxic than alumina ceramic wear particles [11].…”

Section: Introductionmentioning

confidence: 99%

“…The biological response to metal wear particles depends on their size, shape and chemical composition [1,[10][11][12][14][15][16][17]. A precise characterization of the particulate wear debris generated in vivo has become crucial for the understanding of their bioreactivity.…”

Section: Introductionmentioning

confidence: 99%

Wear debris from hip prostheses characterized by electron imaging

Topolovec

Milošev²,

Cör³

et al. 2013

Open Medicine

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AbstractThe characterization of wear particles is of great importance in understanding the mechanisms of osteolysis. In this unique study, thirty-one tissue samples were retrieved at revision surgeries of hip implants and divided into four groups according to the composition of metal prosthetic components. Tissue samples were first analyzed histologically and then by scanning electron microscopy (SEM) combined with back-scattered electron imaging and energy dispersive X-ray spectroscopy. Therefore, particles were studied directly in situ in tissue sections, without the requirement for particle isolation. The composition of metal wear particles detected in the tissue sections corresponded to the composition of the implant components. A considerable number of large metal particles were actually clusters of submicron particles. The clustering of submicron particles was observed primarily with CoCrMo (cobalt-chromiummolybdenum) and, to a lesser extent, for stainless steel particles. SEM secondary and back-scattered electron imaging was an appropriate and selective method for recognizing the composition of metal particles in the in situ tissue sections, without destroying their spatial relationship within the histology. This method can be used as a screening tool for composition of metal and ceramic particles in tissue sections, or as an additional method for particle identification.

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Comparison of the cytotoxicity of clinically relevant cobalt–chromium and alumina ceramic wear particles in vitro

Cited by 216 publications

References 29 publications

Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements

Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements

Tribocorrosion Behavior of Duplex S/Cr(N) and S/Cr(C) Coatings on CoCrMo Alloy in 0.89 % NaCl Solution

Wear debris from hip prostheses characterized by electron imaging

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