Comparison of the diagnostic accuracy of whole-body MRI and whole-body CT in stage III/IV malignant melanoma

Hausmann, Daniel; Jochum, Susanne; Utikal, Jochen; Hoffmann, Richard Christian; Zechmann, Christian M.; Neff, K. W.; Goerdt, Sergij; Schoenberg, Stefan O.; Dinter, Dietmar

doi:10.1111/j.1610-0387.2011.07614.x

Cited by 20 publications

(29 citation statements)

References 38 publications

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“…Consistent interpretations of CT findings based on 2D and 3D measurements as well as information on tumor vascularization represent substantial benefits of this procedure [627]. Downsides to CT are its limited soft tissue contrast and radiation exposure which, depending on protocol, amounts up to 10-20 mSv.…”

Section: Ct/mrimentioning

confidence: 99%

“…Whole-body computed tomography represents a very sensitive procedure, which even allows for the detection of metastases as small as 2-4 mm [627]. In a study by Romano et al, 72 % of asymptomatic distant metastases were discovered by CT scans [605], while other trials yielded detection rates of 15-28 % [109, 116, 441, 612].…”

Section: Ct/mrimentioning

confidence: 99%

“…Especially in the diagnosis of small pulmonary metastases, CT exams have shown a higher sensitivity [627] compared to MRI (66.9 vs. 2.9 %, p < 0.0001) and should therefore be employed as primary diagnostic method in the evaluation of these lesions.…”

Section: Ct/mrimentioning

confidence: 99%

“…Magnetic resonance imaging has proven to be more sensitive and specific in the detection of soft tissue metastases or abdominal metastases (e.g. lymph nodes, liver, adipose tissue, muscle) [303,627].…”

Section: Ct/mrimentioning

confidence: 99%

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Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Pflugfelder

Kochs

Blum

et al. 2013

J Deutsche Derma Gesell

181

148

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Section: Ct/mrimentioning

confidence: 99%

Section: Ct/mrimentioning

confidence: 99%

Section: Ct/mrimentioning

confidence: 99%

Section: Ct/mrimentioning

confidence: 99%

See 2 more Smart Citations

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

Pflugfelder

Kochs

Blum

et al. 2013

J Deutsche Derma Gesell

181

148

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“…MRI has proven to be more sensitive and specific in the detection of soft tissue and osseous metastases as well (31), but there is no strong data directly comparing MRI to CT in osseous metastasis (32). Whole-body CT is a sensitive procedure, which allows for the detection of metastases as small as 2-4 mm (31).…”

Section: Computed Tomography/magnetic Resonance Imagingmentioning

confidence: 99%

Short-Term and Long-Term Management of Melanoma

Goel

Ward

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

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Without consensus guidelines for surveillance in patients with resected melanoma, much debate exists on the appropriate short-term and long-term management of melanoma. When discussing surveillance, it is also important to keep in mind the long-term impact of ongoing surveillance in terms of improved survival, patient quality of life, cost effectiveness, and exposure to risks associated with certain surveillance methods. Most studies recommend frequent follow-up visits with dermatologic surveillance to detect potentially curable recurrence, especially resectable locoregional recurrences. Surveillance laboratory tests and chest x-rays (CXR) can have limited value while producing a relatively high falsepositive rate. Lymph node ultrasonography is a valuable imaging modality in patients with equivocal lymphatic nodal basin physical examinations. In patients with early stages of melanoma, the benefit of routine surveillance imaging studies is questionable; however, close surveillance with detailed medical history and physical examination is necessary, with special attention to regional recurrences every 3-12 months, depending on the American Joint Committee on Cancer (AJCC) stage category the patient falls into and the risk of recurrence. In Stage III or greater, more frequent surveillance in the form of more frequent physical examination, laboratory tests based on symptomatology, and cross-sectional imaging 162may be indicated because of the higher risk of recurrence in this population. CT, MRI, and/or PET/CT are often a component of the overall follow-up for these high-risk patients. Additional studies are needed to better define the role of surveillance in the asymptomatic patient with resected melanoma.

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