Comparison of the diagnostic accuracy of dynamic and static preload indexes to predict fluid responsiveness in mechanically ventilated, isoflurane anesthetized dogs

Validation of the Unesp-Botucatu composite scale to assess acute postoperative abdominal pain in sheep (USAPS)

“…The diagnostic uncertainty zone was determined by two methods, calculating: 1) the 95% CI replicating the original ROC curve 1,001 times by the bootstrap method ("ci.coords" and "ci.auc" functions of "pROC" package); 2) the interval between the sensitivity and specificity values of 0.90. The highest interval of one of these two methods was considered the diagnostic uncertainty zone, which indicates the diagnostic accuracy [55,56].…”

“…Interpretation of AUC � 0.95-high discriminatory capacity. Two-graph ROC curve, CI of 1,001 replications, and of sensitivity and specificity > 0.90 applied to estimate the diagnostic uncertainty zone of the cut-off point of all grouped evaluators, according to the Youden index for the Unesp-Botucatu sheep acute composite pain scale (USAPS) [55,56]. The diagnostic uncertainty zone was 4 to 5; < 4 indicates pain-free sheep (true negative) and > 5 indicates sheep suffering pain (true positive).…”

Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia

“…The small FC volume used in this study is in the range recently suggested for dogs under general anaesthesia [8] and can be considered less aggressive for haemodynamic stable clinical cases to avoid the risk of overhydration especially in cases in which the FC should be repeated during surgery. Other similar veterinary studies have used larger volumes for the FC: Sano et al [12] 10 mL/kg of hydroxyethyl starch administered in 13 min; Fantoni et al [26] 15 mL/kg of Ringer's lactate administered in 15 min; Celeita-Rodriguez et al [28] 20 mL/kg of Ringer's lactate in 15 min; Drozdzynska et al [27] 0 mL/kg of sodium lactate solution administered in 10 min; Rabozzi & Franci [44] 3 mL/kg of Hartmann's solution administered in 1 min; and Bucci et al [45] 5 mL/kg of Ringer's lactate solution in 1 min. If we exclude the last three studies characterised by completely different settings and protocols, the rest of the studies gave 58% [12], 76% [26], and 100% [28] rate of responders.…”

“…Other similar veterinary studies have used larger volumes for the FC: Sano et al [12] 10 mL/kg of hydroxyethyl starch administered in 13 min; Fantoni et al [26] 15 mL/kg of Ringer's lactate administered in 15 min; Celeita-Rodriguez et al [28] 20 mL/kg of Ringer's lactate in 15 min; Drozdzynska et al [27] 0 mL/kg of sodium lactate solution administered in 10 min; Rabozzi & Franci [44] 3 mL/kg of Hartmann's solution administered in 1 min; and Bucci et al [45] 5 mL/kg of Ringer's lactate solution in 1 min. If we exclude the last three studies characterised by completely different settings and protocols, the rest of the studies gave 58% [12], 76% [26], and 100% [28] rate of responders. The rate of responders found in this study (62.5%), fits in between the previous results, despite the smaller volume of the FC, but we cannot exclude that the relatively small volume of FC used could have provided false negative cases, and future studies are required to address the most adequate volume to perform a FC in dogs.…”

“…The grey-zone approach [36] was used to determine each parameter's inconclusive range using the two-steps approach as previously reported in the literature [28,37]. The percentage of individuals of the original study population that fell into the grey zone was calculated as an estimate of the diagnostic accuracy.…”