Comparison of the Diagnostic Performances of Ultrasound, <scp>High‐Resolution</scp> Magnetic Resonance Imaging, and Positron Emission Tomography/Computed Tomography in a Rabbit Carotid Vulnerable Plaque Atherosclerosis Model

Xu, Lei; Wang, Ren‐Jie; Liu, Hongyu; Wang, Jiaoqi; Wang, Liang; Mang, Jing; Zhou, Xu

doi:10.1002/jum.15331

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…The proportions of vulnerable plaque in the three groups with differing degrees of stenosis were therefore different, and the more severe the stenosis, the higher the proportion of vulnerable plaque that was identified. However, vulnerable plaques were also identified in patients with only mild stenosis, which is a finding consistent with that of previous studies (35)(36)(37). This also revealed the danger that, if the degree of vascular stenosis is taken into consideration as the sole determining factor of clinical surgical intervention, the risk assessment is impaired and will result in some patients not receiving effective treatment.…”

Section: Discussionsupporting

confidence: 89%

Significance of high resolution MRI in the identification of carotid plaque

Sun

Jiang

et al. 2020

Exp Ther Med

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The stability of carotid artery plaque serves a key role in the occurrence of stroke. The present study was based on the recruitment of patients with acute ischemic cerebrovascular disease. High-resolution magnetic resonance imaging (HR-MRI) was used to identify the nature of carotid artery plaque, and the results were then used to manage the high-risk group of stroke. The patients were divided equally into a symptomatic group (36 cases) and an asymptomatic group (36 cases). According to the degree of carotid artery stenosis, the patients were divided into mild, moderate and severe stenosis groups, each group comprising 12 patients, and HR-MRI was performed. The proportion of patients with vulnerable plaque in the symptomatic group was higher compared with that in the asymptomatic group (P<0.05). The more severe the stenosis, the higher the proportion of vulnerable plaque that was identified (P<0.05). Compared with carotid ultrasound, HR-MRI was indicated to have the capability to both identify and quantify the different components in the plaque, allowing an assessment of its properties. In conclusion, the present study demonstrated that carotid HR-MRI is able to distinguish and quantify the different components of plaque, which may prove to be helpful for the hierarchical management of a population at high risk of stroke.

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Section: Discussionsupporting

confidence: 89%

Significance of high resolution MRI in the identification of carotid plaque

Sun

Jiang

et al. 2020

Exp Ther Med

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“…High-resolution "bright blood" 3D-TOF technology and "black blood" technology can not only improve the contrast between lumen and wall but also obtain the composition information and morphology of carotid plaque, such as identifying its composition, measuring its total volume, evaluating its morphology and surface of the plaque. 35 It has become a non-invasive "gold standard" for identifying vulnerable plaques. 36 Of course, as non-invasive imaging technology, HRMRI also has limitations in evaluating plaque vulnerability: (1) slow imaging speed, numerous contraindications (such as metal implants in the body or suffering from claustrophobia, etc.)…”

Section: High-resolution Magnetic Resonance Imaging (Hrmri)mentioning

confidence: 99%

“…As a non‐invasive method with high spatial resolution, high tissue resolution, and good reproducibility, HRMRI uses multi‐sequence contrast‐enhanced imaging to clearly display the substructure of blood vessels from adventitia to lumen, allowing for the identification of internal components of carotid plaque and subsequent determination of its nature (Figure 3). High‐resolution “bright blood” 3D‐TOF technology and “black blood” technology can not only improve the contrast between lumen and wall but also obtain the composition information and morphology of carotid plaque, such as identifying its composition, measuring its total volume, evaluating its morphology and surface of the plaque 35 . It has become a non‐invasive “gold standard” for identifying vulnerable plaques 36 .…”

Section: Imaging Diagnosis Of Carotid Vulnerable Plaquesmentioning

confidence: 99%

Imaging diagnosis and research progress of carotid plaque vulnerability

Zhang

Lyu

et al. 2022

J of Clinical Ultrasound

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Ischemic stroke (IS) exhibits a high disability rate, mortality, and recurrence rate, imposing a serious threat to human survival and health. Its occurrence is affected by various factors. Although the previous research has demonstrated that the occurrence of IS is mainly associated with lumen stenosis caused by carotid atherosclerotic plaque (AP), recent studies have revealed that many patients will still suffer from IS even with mild carotid artery lumen stenosis. Blood supply disturbance causes 10% of IS to the corresponding cerebral blood supply area caused by carotid vulnerable plaque. Thrombus blockage of distal branch vessels caused by rupture of vulnerable carotid plaque is the main cause of ischemic stroke. Therefore, how to accurately evaluate vulnerable plaque and intervene as soon as possible is a problem that needs to be solved in clinic. The vulnerability of plaque is determined by its internal components, including thin and incomplete fibrous cap, necrotic lipid core, intra‐plaque hemorrhage, intra‐plaque neovascularization, and ulcerative plaque formation. The development of imaging technology enables the routine detection of AP vulnerability. By analyzing the pathological changes, characteristics, and formation mechanism of carotid plaque vulnerability, this article aims to explore the modern imaging methods which can be used to identify plaque composition and plaque vulnerability to provide a reference basis for disease diagnosis and differential diagnosis.

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“…Carotid ultrasound is fast, easy and applied widely, being able to detect thrombi, plaques, intra-plaque hemorrhage, and completeness of the arterial wall in proximal ICA segments 28 . High-resolution MRI is able to effectively display arterial components, demonstrate the plaque size and range, and make quantitative and qualitative imaging of the occluded artery for both proximal and intracranial ICA plaques 31 – 34 . Nonetheless, 3D-TOF imaging may be needed for tortuous arteries with partial volume effect because the tortuous arteries may be regarded as thickened intima 35 , 36 .…”

Section: Discussionmentioning

confidence: 99%

Significance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery

Zhao,

Xu,

Xue

et al. 2024

Sci Rep

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To investigate the significance of atherosclerotic plaque location in hybrid surgery comprising both endovascular recanalization approaches and carotid endarterectomy for symptomatic atherosclerotic non-acute long-segment occlusion of the internal carotid artery (ICA), 162 patients were enrolled, including 120 (74.1%) patients in the proximal plaque group and 42 (25.9%) in the distal plaque group. Surgical recanalization was performed in all patients, with successful recanalization in 119 (99.2%) patients in the proximal and 39 (92.9%) in the distal plaque group. The total successful recanalization rate was 97.5% (158/162) with a failure rate of 2.5% (4/162). Periprocedural complications occurred in 5 (4.2% or 5/120) patients in the proximal plaque group, including neck infection in two (1.7%), recurrent nerve injury in 1 (0.8%), and laryngeal edema in 2 (1.7%), and 2 (4.8%) in the distal plaque group, including femoral puncture infection in 2 (4.8%). No severe complications occurred in either group. Univariate analysis showed plaque location was a significant (P = 0.018) risk factor for successful recanalization, and multivariate analysis indicated that the plaque location remained a significant independent risk factor for recanalization success (P = 0.017). In follow-up 6–48 months after the recanalization surgery, reocclusion occurred in two (2.8%) patients in the proximal plaque group and 4 (13.3%) in the distal plaque group. In conclusion, although hybrid surgery achieves similar outcomes in patients with ICA occlusion caused by either proximal or distal atherosclerotic plaques, plaque location may be a significant risk factor for successful recanalization of symptomatic non-acute long-segment ICA occlusion.

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Comparison of the Diagnostic Performances of Ultrasound, High‐Resolution Magnetic Resonance Imaging, and Positron Emission Tomography/Computed Tomography in a Rabbit Carotid Vulnerable Plaque Atherosclerosis Model

Cited by 6 publications

References 26 publications

Significance of high resolution MRI in the identification of carotid plaque

Significance of high resolution MRI in the identification of carotid plaque

Imaging diagnosis and research progress of carotid plaque vulnerability

Significance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery

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