2024
DOI: 10.1038/s41598-023-50664-6
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Comparison of the differentiation of ovine fetal bone-marrow mesenchymal stem cells towards osteocytes on chitosan/alginate/CuO-NPs and chitosan/alginate/FeO-NPs scaffolds

Leila Soltani,
Kambiz Varmira,
Maryam Nazari

Abstract: In the current study, the creation of a chitosan/alginate scaffold hydrogel with and without FeO-NPs or CuO-NPs was studied. From fetal ovine bone marrow mesenchymal stem cells (BM-MSCs) were isolated and cultivated. Their differentiation into osteocyte and adipose cells was investigated. Also, on the scaffolds, cytotoxicity and apoptosis were studied. To investigate the differentiation, treatment groups include: (1) BM-MSCs were plated in DMEM culture medium with high glucose containing 10% FBS and antibiotic… Show more

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Cited by 2 publications
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“…Alginate exhibits a range of characteristics, including low immunogenicity, biodegradability, and an affinity for metal ions, leading to the formation of highly robust gels [ 18 , 19 ]. On the other hand, chitosan offers advantageous properties such as antibacterial and hemostatic effects [ 20 ], as well as biocompatibility, and non-toxicity [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Alginate exhibits a range of characteristics, including low immunogenicity, biodegradability, and an affinity for metal ions, leading to the formation of highly robust gels [ 18 , 19 ]. On the other hand, chitosan offers advantageous properties such as antibacterial and hemostatic effects [ 20 ], as well as biocompatibility, and non-toxicity [ 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, chitosan offers advantageous properties such as antibacterial and hemostatic effects [ 20 ], as well as biocompatibility, and non-toxicity [ 18 ]. Nevertheless, due to some drawbacks, chitosan is utilized in combination with other biomaterials [ 19 ].…”
Section: Introductionmentioning
confidence: 99%