Comparison of the distribution of non-AIDS Kaposi’s sarcoma and non-Hodgkin’s lymphoma in Europe

Maso, Luigino Dal; Franceschi, Silvia; Re, A. Lo; Vecchia, Carlo La

doi:10.1038/sj.bjc.6690026

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Nonetheless, geographical disparities in the incidence of lymphoma subtypes have been documented which may shed light on the pathogenesis of some lymphoma variants and potentially relate to the unequal prevalence of viral carcinogens, other currently unidentified environmental factors, and ethnic and/or genetic susceptibility factors. [21222324252627]…”

Section: Discussionmentioning

confidence: 99%

Oral and cutaneous lymphomas other than mycosis fungoides and sézary syndrome in a mexican cohort: Recategorization and evaluation of international geographical disparities

et al. 2017

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Background:Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.Aims:This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts.Materials and Methods:Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications.Results:Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein–Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety.Conclusions:Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction.

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