Comparison of the doubly labeled water (2H218O) method with indirect calorimetry and a nutrient-balance study for simultaneous determination of energy expenditure, water intake, and metabolizable energy intake in preterm infants

Roberts, Steven B.; Coward, W. A.; Schlingenseipen, K.-H.; Nohria, Virinder; Albacete-Albacete, Lucas

doi:10.1093/ajcn/44.3.315

Cited by 151 publications

(71 citation statements)

References 18 publications

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“…The DLW technique is non-invasive, completely safe and involves minimal subject burden. The technique enables a precise estimation of metabolizable energy intake among free-living individuals, including infants and young children (Roberts et al, 1986;Jones et al, 1987). The mean TEE in the current study was 309 ± 46 kJ/kg/day for the 9-month-old infants.…”

Section: Discussionmentioning

confidence: 58%

Validation of a pre-coded food record for infants and young children

et al. 2011

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Background/Objectives: To assess the validity of a 7-day pre-coded food record (PFR) method in 9-month-old infants against metabolizable energy intake (ME DLW ) measured by doubly labeled water (DLW); additionally to compare PFR with a 7-day weighed food record (WFR) in 9-month-old infants and 36-month-old children. Subjects/Methods: The study population consisted of 36 infants (age: 9.03±0.2 months) and 36 young children (age: 36.1 ± 0.3 months) enrolled in a cross-over design of 7 consecutive days PFR vs 7 consecutive days WFR. Children were randomly assigned to one method during week 1, crossing over to the alternative method in week 2. Total energy expenditure (TEE) and ME DLW were obtained in the 9-month-old infants using the DLW technique for 7 days while recording with PFR. Results: For the 9-month-old group, PFR showed a mean bias of þ 726 kJ/day, equivalent to 24%, (Po0.0001) compared with ME DLW (n ¼ 29). Using WFR as the reference in this group no between-method differences were found for energy, fat and carbohydrate. Energy intake in the 36-month-old children was 12% higher in the PFR vs WFR (Po0.0001), and protein plus total fat intake were overestimated with the PFR (P ¼ 0.008, Po0.0001, respectively). Conclusions: The study indicates that the PFR may be a valuable tool for measuring energy, energy-yielding nutrients and foods in groups of 9-month-olds infants and 36-month-olds young children.

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Section: Discussionmentioning

confidence: 58%

Validation of a pre-coded food record for infants and young children

et al. 2011

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“…It is noteworthy that the differ OBES ITY RESEARCH Vol. ence between the rates of 2H and 18o disappearance was extremely small in this subject, with a kc/kd ratio comparable to that found in premature infants (9). Under these circumstances, the doubly labeled water method becomes very sensitive to analytical error (8) and error can be expected to be increased by more than 50% relative to those observed wben k 0 /kd is 1.3 .…”

Section: Human Subjectssupporting

confidence: 50%

“…Since its frrst application to human subjects over a decade ago (14) several validation studies in adult and infant subjects have compared the doubly labeled water method with nearly-continuous indirect calorimetry (1,6,7,9,13,(15)(16)(17) . These studies have consistently shown a close agreement between values for carbon dioxide production determined by the two techniques.…”

Section: Introductionmentioning

confidence: 99%

Multiple Laboratory Comparison of the Doubly Labeled Water Technique*

et al. 1995

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A double-blind study was conducted to determine between-laboratory variability in the doubly labeled water method for measurement of total energy expenditure in humans, and to compare the accuracy and precision of three widely-used procedures for calculating rates of carbon dioxide production from the original isotope data. Eighteen laboratories from five countries participated in the study. All laboratories were provided with five water standards containing varying amounts of 2H and 18o, and in addition 11 laboratories were provided with urine and dose specimens from one (six laboratories) or two (five laboratories) healthy elderly subjects of normal height and weight undergoing a calorimetric valida-' tion of the doubly labeled water method. The data from the five water standards were analyzed to predict between-laboratory variability in the doubly labeled water technique in all laboratories. In addition, data from the subjects were analyzed using the "slope-intercept", "2-point" and "modified" methods of calculation.The results confirm that the doubly labeled water method can be an accurate technique for the measurement of energy expenditure in adult human sub-*This paper was prepared on behalf of the committee who contributed data, and a draft was sent to all participants for comments . From the tUSDA Human

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“…4 The DLW method has been validated against both gaseous exchange (GE) (considered to be the gold standard for the estimation of energy expenditure (EE)), [5][6][7][8][9] and energy balance studies. 10,11 Some variation has been reported between the results of validation studies, which has been attributed to the different physiological states of the individuals and errors associated with different analytical methods undertaken by each laboratory.…”

Section: Introductionmentioning

confidence: 99%

“…No study has investigated the validity of DLW in an obese group since that of Ravussin et al, 15 and other studies yielding individual subject data have not supported a relation between adiposity and error in DLW-estimated TEE. [6][7][8][9][10] There is now a pressing need to re-examine Ravussin's observations and, if they are confirmed, to explore further the mechanisms by which they may occur.…”

Section: Introductionmentioning

confidence: 99%

Measurement of total energy expenditure in grossly obese women: comparison of the bicarbonate–urea method with whole-body calorimetry and free-living doubly labelled water

et al. 2003

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OBJECTIVE:To establish validity of the bicarbonate-urea (BU) method against direct measurements of gaseous exchange (GE) in a whole-body indirect calorimeter and to compare BU and doubly labelled water (DLW) measurements in free-living conditions in the same group of grossly obese women. DESIGN: Energy expenditure (EE) was estimated by the BU method over 24 h concurrently with whole-body indirect calorimetry and subsequently over 5 consecutive days at home concurrently with 14 day DLW. Six women, body mass index (BMI) 52.4710.4 kg/m 2 (s.d.), were studied. RESULTS: Total energy expenditure (TEE) measurements by BU and GE within the metabolic chamber were not significantly different (BU ¼ 11.7971.89 MJ/day and GE ¼ 11.6471.86 MJ/day; mean difference, 0.2570.49 MJ/day, P40.05). Free-living TEE derived from BU and DLW was also similar (13.2871.86 and 13.8672.25 MJ/day, respectively; mean difference 0.1771.33 MJ/day, Po0.05). The measured physical activity level (PAL) in these very obese subjects was within the range reported in other free-living studies in less obese individuals (1.6270.14 using DLW and 1.5670.20 using BU). The BU method was well tolerated by the subjects. CONCLUSIONS: This study in grossly obese subjects, heavier than those participating in previous studies involving tracer methods, demonstrates validity of the BU against GE under controlled metabolic conditions, and the equivalence between BU and DLW under free-living conditions. The results suggest that both tracer methods are valid in this population group. This study also demonstrates the practicalities of using the BU method over 5 days, the longest application of the method so far.

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Comparison of the doubly labeled water (2H218O) method with indirect calorimetry and a nutrient-balance study for simultaneous determination of energy expenditure, water intake, and metabolizable energy intake in preterm infants

Cited by 151 publications

References 18 publications

Validation of a pre-coded food record for infants and young children

Validation of a pre-coded food record for infants and young children

Multiple Laboratory Comparison of the Doubly Labeled Water Technique*

Measurement of total energy expenditure in grossly obese women: comparison of the bicarbonate–urea method with whole-body calorimetry and free-living doubly labelled water

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