Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism

Shirakawa, Takashi; Nakajima, Katsuyuki; Shimomura, Y; Kobayashi, Junji; Stanhope, Kimber L.; Havel, Peter J.; Machida, Tetsuo; Sumino, Hiroyuki; Murakami, Masami

doi:10.1016/j.cca.2014.07.020

Cited by 28 publications

(31 citation statements)

References 40 publications

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“…These results suggested that an increase of LPL is associated with an increase of remnant lipoproteins. However, we recently reported that the amount of LPL present per RLP particle was inversely correlated with the RLP-TG or RLP-LPL/ RLP-TG ratio (reflecting particle size) [26,33]. This means that RLP with large particle size may be the result of insufficient hydrolysis of TG-rich lipoproteins by LPL on the endothelium after fat intake.…”

Section: Discussionmentioning

confidence: 97%

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Lipoprotein lipase does not increase significantly in the postprandial plasma

Ishiyama

Sakamaki

Shimomura

et al. 2017

Clinica Chimica Acta

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Section: Discussionmentioning

confidence: 97%

“…The LPL plasma concentration was measured using a novel LPL-ELISA developed at Immuno-Biological Laboratories (IBL) [26]. This is a solid phase sandwich ELISA using 2 kinds of highly specific monoclonal antibodies against human recombinant LPL.…”

Section: The Sandwich Lpl-elisa Proceduresmentioning

confidence: 99%

Lipoprotein lipase does not increase significantly in the postprandial plasma

Ishiyama

Sakamaki

Shimomura

et al. 2017

Clinica Chimica Acta

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“…50 This effect remained significant after adjustment for blood pressure, diabetes, smoking, body mass index and LDL-C but not after additional adjustment for high-density HDL-C or TG. 50 Recently, Shirakawa et al 51 developed a new highsensitivity LPL measurement system using two different antihuman LPL monoclonal antibodies (Figure 1(b)). They found that remnant-like particles associated with cholesterol (RLP-C) or triglycerides (RLP-TG) and RLP-TG/RLP-C ratio correlated inversely with serum LPL protein concentrations.…”

Section: Studies Suggesting Serum Lpl Protein Concentration Is a Usefmentioning

confidence: 98%

Lipoprotein lipase and atherosclerosis

Kobayashi

Mabuchi

2015

Ann Clin Biochem

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Lipoprotein lipase has long been known to hydrolyse triglycerides from triglycerides-rich lipoproteins. More recently, it has been shown to promote the binding of lipoproteins to various lipoprotein receptors. Evidence is also presented regarding the possible atherogenic role of lipoprotein lipase. In theory, lipoprotein lipase deficiency should help to clarify this question. However, the rarity of this condition means that it has not been possible to conduct epidemiological studies. An alternative approach is to investigate the correlation of lipoprotein lipase with onset of cardiovascular disease in prospective studies in large population-based cohorts. Complementary with this approach, animal models have been used to explore the atherogenicity of lipoprotein lipase expressed by macrophages.

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“…13 The consequences are higher TG-rich VLDL synthesis and secretion from liver to circulation. 14 15 Then, LPL catalyzes the transformation of TG-rich VLDL into sdLDL, 16 promoting atherosclerosis. 17 18 Currently, postprandial hyperlipidemia is a good marker of accelerated atherosclerosis in patients with IR.…”

Section: What Are the New Findings?mentioning

confidence: 99%

Reduced first-phase insulin secretion increases postprandial lipidemia in subjects with impaired glucose tolerance

Gómez-Sámano

Cuevas‐Ramos

Grajales-Gómez

et al. 2017

BMJ Open Diab Res Care

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ObjectiveIt is not clear which phase of insulin secretion is more important to regulate lipoprotein lipase (LPL) activity. After a meal, insulin is released and acts as a major regulator of LPL activity. Postprandial hyperlipidemia is a common comorbidity in subjects with insulin resistance (IR). Therefore this study aimed to evaluate the role of the first-phase insulin secretion (FPIS) on postprandial lipidemia in subjects with IR and impaired glucose tolerance (IGT).Research design and methodsThis is a cross-sectional, observational and comparative study. We included male and female subjects between 40 and 60 years with a body mass index (BMI) between 23 and 30 kg/m2. Then, patients were divided into three groups. Group 1 consisted of control subjects with normal glucose tolerance and preserved FPIS. Group 2 included patients with IGT and a reduced FPIS. Group 3 consisted of subjects with IGT but normal FPIS. Both groups were paired by age and BMI with subjects in the control group. Subjects underwent an intravenous glucose tolerance test to classify each case, and then a load with a mixed meal load to measure postprandial lipidemia.ResultsA total of 32 subjects were evaluated: 10 were control subjects, 8 subjects with IGT with a reduced FPIS and 14 subjects with IGT and preserved FPIS. After administration of a standardized meal, group 2 showed a greater glucose area under the curve (AUC) at 30 and 120 min (p=0.001, for both). This group also showed a statistically significant increase (p<0.001) in triglyceride AUC.ConclusionsA reduced FPIS is significantly and independently associated with a larger postprandial hyperlipidemia in subjects with IGT.

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Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism

Abstract: LPL activity and concentration were inversely and significantly correlated with the particle size of RLP in both the post-heparin and pre-heparin plasma. Those results suggest that LPL concentration in pre-heparin plasma can take the place of LPL activity in the post-heparin plasma.

Cited by 28 publications

References 40 publications

Lipoprotein lipase does not increase significantly in the postprandial plasma

Lipoprotein lipase does not increase significantly in the postprandial plasma

Lipoprotein lipase and atherosclerosis

Reduced first-phase insulin secretion increases postprandial lipidemia in subjects with impaired glucose tolerance

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