Comparison of the effect of dietary casein and cottonseed protein on food intake and growth in normal and tumorbearing rats

Radcliffe, John D.

doi:10.1016/s0271-5317(05)80398-7

Cited by 1 publication

(3 citation statements)

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“…(14). Lipids were extracted ~om serum and tumors as described previously (4,15). Fatty acids in sertun and MCS lipids were converted to methyl esters as described by Radcliffe (4).…”

Section: Biochemistry Andmolecular Biology Internationalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…This methylcholanthrene-induced sarcoma (MCS) has been widely used to study the effect of dietary manipulations on tmnor growth and the way in which tumor growth brings about changes in host metabolism (2)(3)(4)(5). These changes include the induction of both hypoalbuminemia and a hyperlipidemia characterized by greatly increased serum levels of triglycerides (or triacylglycerols), cholesterol, phosphotipids, and total lipids (4). In 1990, Radcliffe and Edwards (6), who used growing male rats implanted with the MCS, found that the serum levels of both triglycerides and cholesterol in tumorbearing rats fed a diet containing 2% corn oil (CO) + 8% fish oil (FO) were lower than in ones fed a diet containing 10% CO, demonstrating, for the first time, that dietary FO could be used to reduce the severity of tmnor-induced hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary fish oil on tumor‐induced hyperlipidemia and tumor growth in rats implanted with a methylcholanthrene‐induced sarcoma

et al. 1999

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Summary: Male Fischer 344 rats implanted with a methylcholanthrene-induced sarcoma (MCS), along with normal (or control) animals, were fed diets containing either 10% corn oil (CO) or 2% CO + 8% fish oil (FO), designated as diets CO and FO, respectively, in a study designed to determine the effect of dietary FO on serum lipids (in the presence or absence of a tumor) and the growth and fatty acid composition of the MCS. For both diets, MCS-bearing rats had significantly (p<0.05) higher serum levels of triglycerides, cholesterol, phospholipids, and total lipids than controls. For both controls and tumor-bearers, serum levels of all these lipids were, with the exception of cholesterol for the tumorbearers, significantly lower in rats receiving the FO diet than for the corresponding groups receiving the CO diet. Relative to rats fed the CO diet, those fed the FO diet had significantly higher serum levels of some fatty acids (e.g,, 20"5n-3) but significantly lower levels of others (e.g., 18:2n-6), regardless of tumor status. For the tumor-bearers, differences in the levels of fatty acids in MCS tissue reflected differences in the fatty acid composition of total serum lipids. Sarcoma growth was unaffected by diet. Thus, feeding dietary FO resulted in changes in the lipid status of both control and tumor-bearing rats. Since sarcoma growth was unaffected by diet, the reduction in the severity of MCS-induced hyperlipidernia by FO appears to be due to an effect of the oil per se.

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“…(14). Lipids were extracted ~om serum and tumors as described previously (4,15). Fatty acids in sertun and MCS lipids were converted to methyl esters as described by Radcliffe (4).…”

Section: Biochemistry Andmolecular Biology Internationalmentioning

confidence: 99%