Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy

Özler, Mehmet; Şimşek, Kemal; Özkan, Cansel Köse; Akgül, Emin Özgür; Topal, Turgut; Öter, Şükrü; Korkmaz, Ahmet

doi:10.3109/00365513.2010.506926

Cited by 40 publications

(35 citation statements)

References 22 publications

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“…As melatonin exerts numerous antioxidant actions, a suppression of melatonin by LAN should be expected to decrease antioxidative mechanisms inasmuch as they depend on physiological nocturnal melatonin levels [ 232 ]. This assumption would be in line with the repeatedly observed increases in lipid peroxidation and decreases in glutathione peroxidase and superoxide dismutase in pinealectomized animals (e.g., [ 233 , 234 , 235 , 236 ]). Such a direct reduction of protective capacity must be distinguished from perturbed rhythms in protective enzymes and mitochondrial activity, which are induced by phase-shifting light signals that occur in inappropriate circadian phases and represent another aspect of chronodisruption.…”

Section: Output Pathways: Melatoninsupporting

confidence: 70%

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

Bonmatí-Carrión

Arguelles-Prieto

Martínez-Madrid

et al. 2014

IJMS

183

115

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Currently, in developed countries, nights are excessively illuminated (light at night), whereas daytime is mainly spent indoors, and thus people are exposed to much lower light intensities than under natural conditions. In spite of the positive impact of artificial light, we pay a price for the easy access to light during the night: disorganization of our circadian system or chronodisruption (CD), including perturbations in melatonin rhythm. Epidemiological studies show that CD is associated with an increased incidence of diabetes, obesity, heart disease, cognitive and affective impairment, premature aging and some types of cancer. Knowledge of retinal photoreceptors and the discovery of melanopsin in some ganglion cells demonstrate that light intensity, timing and spectrum must be considered to keep the biological clock properly entrained. Importantly, not all wavelengths of light are equally chronodisrupting. Blue light, which is particularly beneficial during the daytime, seems to be more disruptive at night, and induces the strongest melatonin inhibition. Nocturnal blue light exposure is currently increasing, due to the proliferation of energy-efficient lighting (LEDs) and electronic devices. Thus, the development of lighting systems that preserve the melatonin rhythm could reduce the health risks induced by chronodisruption. This review addresses the state of the art regarding the crosstalk between light and the circadian system.

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Section: Output Pathways: Melatoninsupporting

confidence: 70%

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

Bonmatí-Carrión

Arguelles-Prieto

Martínez-Madrid

et al. 2014

IJMS

183

115

View full text Add to dashboard Cite

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“…It has been shown that as an antioxidant, melatonin is at least twice as effective as vitamin E and five times more effective than glutathione (4,20). A few studies have demonstrated melatonin's potential effect on flap viability (4,5,21). Gurlek et al (4,5) performed pinealectomies in rats to prevent circadian melatonin secretion, thus enabling the assessment of antioxidant effects of exogenous melatonin.…”

Section: Discussionmentioning

confidence: 99%

Assessing the effects of melatonin and N-acetylcysteine on the McFarlane flap using a rat model

Tunc¹,

Kesikdas²,

Yilmaz³

2016

J Plastic Surgery

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“…Bulbuller et al (2005) observed that subcutaneous melatonin application decreased collagen synthesis and epithelium proliferation and indicated undesirable effects on incision and anastomotic wound healing in normal and pinealectomized rats. However, positive improvement in the wound healing process has been detected due to topically and systematically administered melatonin on chronic wound healing in rats with pinealectomy (Ozler et al, 2010) and also on pressure ulcer in rats (Sener et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The effects of topical melatonin on oxidative stress, apoptosis signals,and p53 protein expression during cutaneous wound healing

Şener¹,

Çevik²,

Doğan³

et al. 2015

Turk J Biol

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IntroductionWound healing is a complex and well-designed repair process that occurs after any injury, such as surgical procedures or trauma. The process is divided into three serial phases: inflammation, tissue formation, and tissue remodeling (Wu and Chen, 2014). Apoptosis is important to the wound healing process, especially in removing inflammatory cells and inhibiting scar formation. The early phase of inflammation is characterized by the invasion of neutrophils, macrophages, and lymphocytes to the wound area. The fibroblasts then migrate and synthesize extracellular matrix components. Inflammatory cells must be removed in order to begin this next phase of wound healing. Remodeling of granulation tissue during the wound healing process is also accompanied by the apoptosis of fibroblasts (Rai et al., 2005;Wu and Chen, 2014). Dysregulation in these apoptotic processes may result in abnormal wound healing, such as hypertrophic scars and keloid formation (Greenhalgh, 1998), or may delay wound healing (Deveci et al., 2005;Blakytny and Jude, 2006). p53 is generally known as a tumor suppressor and can induce apoptosis via transcription-dependent or -independent mechanisms (Lippens et al., 2009). Reactive oxygen species (ROS) that arise after cutaneous injury may worsen the healing process and induce apoptosis (Hameedaldeen et al., 2014). Low and normal levels of ROS play important roles in wound repair and signal transduction for reepithelialization and proliferation of cells, such as the collagenase activity and the epidermal growth factor signaling. However, higher levels of ROS can cause oxidative stress and may damage intracellular macromolecules such as DNA, lipids, and proteins. Therefore, regulating oxidative stress and the inflammatory response is important during the cutaneous wound healing process (Schäfer and Werner, 2008;Hameedaldeen et al., 2014). The utilization of antioxidants has been considered as an effective therapeutic approach in wound healing (James et al., 2001;Sharifi et al., 2012). Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced primarily by the pineal gland and secreted in the dark during night. It modulates sleep, reproduction, circadian rhythm, and immunity. Additionally, melatonin is a potent antioxidant and directly detoxifies oxygen and nitrogen-based reactants Sener et al., 2009). It affects the activity and the levels of cellular mRNA of antioxidant enzymes including Abstract: Elimination of reactive oxygen species (ROS) can be an important strategy to improve healing of wounds. ROS have an effect on proliferation and cell survival signaling, which results in alteration of apoptotic pathways in cells. Melatonin has antioxidant properties on skin wounds. In our study, we investigated the effects of topical melatonin (3%, w/w) on apoptosis and p53 protein expression together with parameters of oxidative stress in a cutaneous excision wound model. Bcl-2 protein levels in wound tissue at the end of days 3, 7, and 14 were significantly increased, while caspase-3 activity an...

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Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy

Abstract: In conclusion, in the present study it was shown that wound healing was prolonged in experimental animals deprived of melatonin through pinealectomy. Melatonin exerts positive effects on wound healing, whether it is administered topically or systemically.

Cited by 40 publications

References 22 publications

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

Assessing the effects of melatonin and N-acetylcysteine on the McFarlane flap using a rat model

The effects of topical melatonin on oxidative stress, apoptosis signals,and p53 protein expression during cutaneous wound healing

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