Comparison of the Effect of Fluoride Varnish, Chlorhexidine Varnish and Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) Varnish on Salivary Streptococcus mutans Level: A Six Month Clinical Study

Patel, Punit; Hugar, Shivayogi M; Halikerimath, Seema; Badakar, Chandrashekhar; Gokhale, Niraj; Thakkar, Prachi; Kohli, Divyata; Shah, Shreyas

doi:10.7860/jcdr/2017/26541.10409

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…When the pH of plaque drops, CaF 2 begins to dissolve and release fluoride ions; therefore, it acts as a prolonged source of fluoride after application. [ 18 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

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In vitro comparison of antimicrobial activity of conventional fluoride varnishes containing xylitol and casein phosphopeptide-amorphous calcium phosphate

Jafari¹,

Hekmatfar²,

Fereydunzadeh³

2018

J Int Soc Prevent Communit Dent

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Objective:Different fluoride varnishes are used for the prevention of dental caries. The aim of this study was to compare the antimicrobial effect of different fluoride varnishes, containing xylitol and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), on Streptococcus mutans.Materials and Methods:In this in vitro study, the antibacterial effects of four varnishes, namely Polimo and V-varnish (containing xylitol), MI varnish (containing CPP-ACP), and Preventa, were evaluated against S. mutans. The disc diffusion method was used for testing the bacterial sensitivity. The data were analyzed using the Kruskal–Wallis and Mann–Whitney U-tests.Results:According to the results, Polimo showed the highest antibacterial effects, compared to the other three varnishes (P ≤ 0.05). Growth inhibition zones were not observed in V-varnish and Preventa. The mean diameter of inhibition zone around the MI varnish was significantly higher, compared to those of the V varnish and Preventa (P ≤ 0.05).Conclusion:As the findings indicated, the fluoride varnish containing xylitol and CPP-ACP could be more effective iAQ1n the prevention of dental caries.

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“…When the pH of plaque drops, CaF 2 begins to dissolve and release fluoride ions; therefore, it acts as a prolonged source of fluoride after application. [ 18 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

“…This result could be due to the additive anticariogenic effect of CPP-ACP and fluoride attributable to localization of ACPF at the tooth surface by the CPP. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

In vitro comparison of antimicrobial activity of conventional fluoride varnishes containing xylitol and casein phosphopeptide-amorphous calcium phosphate

Jafari¹,

Hekmatfar²,

Fereydunzadeh³

2018

J Int Soc Prevent Communit Dent

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“…or clinical study about different varnish products on salivary S.M. count (14)(15)(16). In these studies, less attention has been paid to the antimicrobial properties of varnishes against L.A. Because the structural and metabolic characteristics of each microorganism are different from those of other microorganisms, the results of studies that are related to S.M.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antimicrobial Activity of Fluoride Varnishes Against Streptococcus mutans and Lactobacillus acidophilus: An In Vitro Study

Soleimani

Goli

Naranjian³

et al. 2021

Iran J Pediatr

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Background: Topical fluoride products such as varnishes prevent dental caries by limiting demineralization and antibacterial properties. The structural and metabolic characteristics of cariogenic microorganisms are different from each other. Also, the formulation properties, concentration, and release behavior of fluoride vary in different varnishes. Objectives: In this study, we investigated the antibacterial effects of three types of common fluoride varnishes against two cariogenic bacteria of Streptococcus mutans (S.M.) and Lactobacillus acidophilus (L.A.). Methods: In this in vitro study, antibacterial effects of MI varnish [containing calcium phosphopeptide-amorphous calcium phosphate (CPP-ACP)], Polimo (containing xylitol), and FluoroDose varnishes were evaluated using disc diffusion method via measuring the diameter of the inhibition zone. The antibiotics of erythromycin and ampicillin were used as the positive control of the test. Analysis of variance (ANOVA) and post hoc tests were applied to compare the mean of non-growth zone diameter in the studied groups. Data were analyzed by SPSS 16. The statistical significance level was determined as P-value < 0.05. Results: The antibacterial effect of each varnish was optimal against both bacteria. In comparison, the mean diameter of the inhibition zone in MI varnish was significantly (P-value=0.019) higher than Polimo and FluoroDose brands on S.M.; however, this difference was not statistically significant for L.A. Furthermore, Polimo and FluoroDose varnishes showed similar antimicrobial effects against these bacteria. Conclusions: The use of these varnishes seems to be suitable for preventing tooth decay. MI varnish is preferable because of its higher antibacterial properties.

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“…It has been observed from the literature review that in vitro 9 , 10 and clinical studies using fluoride varnish and CPP ACP varnish 11 have been conducted in orthodontic patients. 12 To our knowledge, there exist few in vitro 13 , 14 and clinical studies 15 , 16 which assessed the efficacy of CPP–ACP fluoride varnish in permanent teeth but no clinical study has been done using combination varnishes (NaF with ACP) pertaining to remineralization of white spot lesions in ECC patients. Thus, the purpose of this study was to compare the effect of fluoride varnish and combination of fluoride and CPP–ACP, fluoride with ACP varnishes in reducing the activity and dimension of white spot lesions occurring on smooth surfaces of primary anterior teeth of children with ECC.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of the Remineralizing Efficacy of Fluoride Varnish and its Combination Varnishes on White Spot Lesions in Children with ECC: A Randomized Clinical Trial

Radha¹,

Kayalvizhi²,

Adimoulame³

et al. 2020

International Journal of Clinical Pediatric Dentistry

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A bstract Aim The aim of the study was to assess the remineralizing efficacy of fluoride and its combination varnishes on white spot lesion (WSL) in children with early childhood caries (ECC). Materials and methods Sixty children with active WSL on primary maxillary anterior teeth were randomly selected. At baseline, the WSL activity was evaluated using ICDAS II [lesion activity assessment (LAA)] and its dimensions through photographic method. They were allocated to group I (GI) (5% NaF), group II (GII) [5% NaF with amorphous calcium phosphate (ACP)], and group III (GIII) [5% NaF with casein phosphopeptides – amorphous calcium phosphate (CPP –ACP)]. First, oral hygiene instructions and diet counseling were given followed by application of fluoride varnishes in their respective groups. The same parameters were recorded at follow-up of 2, 4, 12, and 24 weeks intervals. Data were collected and subjected to statistical analysis using Friedman Chi-square and Mann–Whitney tests. Results Overall, the active WSL changed to inactive over a period of 24 weeks in GI was 90%, GII was 95%, and 100% in GIII. There was a significant reduction in dimension of WSL in GI from 4.119 to 2.525 ( p = 0.0001). Likewise, there was a significant reduction in dimension of WSL in GII and GIII from 4.586 to 3.258 and 4.696 to 1.2155, respectively ( p = 0.0001, p = 0.0001). Comparatively, group III (MI varnish) showed statistically significant reduction in the dimension of WSL from baseline to 24 weeks ( p = 0.002). But the results were statistically insignificant with change of active lesions to its inactivity ( p = 0.349). Conclusion Fluoride varnish with CPP–ACP was found to be an effective preventive strategy in reversing WSL in children with ECC. Clinical relevance These combination varnishes could prove to be a promising preventive measure for pediatric dentists in reversing white spot lesions of ECC. Clinical trial registry NCT03360266. How to cite this article Radha S, Kayalvizhi G, Adimoulame S, et al. Comparative Evaluation of the Remineralizing Efficacy of Fluoride Varnish and its Combination Varnishes on White Spot Lesions in Children with ECC: A Randomized Clinical Trial. Int J Clin Pediatr Dent 2020;13(4):311–317.

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Comparison of the Effect of Fluoride Varnish, Chlorhexidine Varnish and Casein Phosphopeptide- Amorphous Calcium Phosphate (CPP-ACP) Varnish on Salivary Streptococcus mutans Level: A Six Month Clinical Study

Cited by 15 publications

References 27 publications

In vitro comparison of antimicrobial activity of conventional fluoride varnishes containing xylitol and casein phosphopeptide-amorphous calcium phosphate

In vitro comparison of antimicrobial activity of conventional fluoride varnishes containing xylitol and casein phosphopeptide-amorphous calcium phosphate

Comparison of Antimicrobial Activity of Fluoride Varnishes Against Streptococcus mutans and Lactobacillus acidophilus: An In Vitro Study

Comparative Evaluation of the Remineralizing Efficacy of Fluoride Varnish and its Combination Varnishes on White Spot Lesions in Children with ECC: A Randomized Clinical Trial

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