Comparison of the Effect of Diisopropyl Phenol (Ici 35 868) and Thiopentone on Response to Somatic Pain

Briggs, L.P.; Dundee, John W.; Bahar, M.; Clarke, R.S.J.

doi:10.1093/bja/54.3.307

Cited by 76 publications

(25 citation statements)

References 10 publications

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“…13 Our findings do not explain the conflicting results obtained in human studies of the effects of subhypnotic effects of thiopental on the response to painful stimulation. 2,17 The present results differ from our findings concerning the facilitation of synaptic transmission in the hippocampus by pentobarbital. 6 There we reported that during stimulation that was not sufficient to induce synaptic plasticity, the addition of pentobarbital enhanced of synaptic transmission for at least three hours following removal of the drug.…”

Section: Discussioncontrasting

confidence: 99%

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Pentobarbital induces nocifensive hyperrflexia, not hyperalgesia in rats

Archer

Samanani

Roth

2000

Can J Anesth/J Can Anesth

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Purpose: To seek behavioural, reflexive and histochemical evidence of long-lasting changes in nociceptive stimulus transmission induced by exposure to doses of pentobarbital that induce nocifensive hyperreflexia.Methods: Nocifensive hyperreflexia was induced in 12 rats with 30 mg·kg -1 pentobarbital ip. Reflex latency times for withdrawal of the hind paw from noxious radiant heat were measured with an automated electronic timer. Subjective responses to noxious stimulation (licking or biting of the stimulated hindpaw) and the level of sedation were recorded. Histological sections of lumbar spinal cord were stained for immunoreactivity of the immediateearly-gene (IEG), c-fos, in three rats that received repeated threshold noxious radiant heat stimulation during the period of nocifensive hyperreflexia induced by 30 mg·kg -1 pentobarbital ip.Results: Reflex withdrawal latency decreased by 32 ± 8% of control values (P < 0.001) following pentobarbital injection and returned to control values 120 min after drug injection. Once fully alert, pentobarbital-treated animals did not show any increase in nociceptive behaviour relative to saline-injected controls (P = 0.41). Sustained noxious stimulation to the hindpaw in halothane-anesthetized animals was associated with an increase in c-fos immunoreactivity in the dorsal horn of the lumbar spinal cord ipsilateral to the stimulation (P < 0.001). Threshold stimulation in the pentobarbital-treated animals was not associated with any increase in c-fos expression.Conclusions: During pentobarbital-induced hyperreflexia, rats did not show any reflexive, behavioural, or histochemical evidence of long-lasting enhancement of nocifensive signal transmission. The results are consistent with previous observations that, in the absence of tissue injury, nocifensive hyperreflexia induced by barbiturates is a short-lived pharmacological effect.Objectif : Découvrir les manifestations comportementales, réflexes et histochimiques de modifications persistantes de la transmission d'un stimulus nociceptif induit par l'exposition à des doses de pentobarbital qui provoquent une surréflectivité défensive.Méthode : La surréflectivité défensive a été induite chez 12 rats avec 30 mg·kg -1 de pentobarbital ip. Les temps de latence réflexe nécessaire au retrait de la patte arrière d'une source de chaleur radiante ont été mesurés avec un chronomètre électronique automatisé. Les réponses subjectives à la stimulation désagréable (lécher ou mordre la patte stimulée) et le niveau de sédation ont été enregistrés. Des sections histologiques de la moelle épinière lombaire ont été colorées pour vérifier l'immunoréactivité du gène précoce immédiat (GPI), c-fos, chez trois rats qui ont reçu une stimulation liminale nocive répétée de chaleur radiante pendant la période de surréflectivité défensive induite par les 30 mg·kg -1 de pentobarbital ip.Résultats : Le temps de latence réflexe a baissé de 32 ± 8 % par rapport aux valeurs témoins (P < 0,001) après l'injection de pentobarbital et est revenu aux valeurs témoins 1...

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Section: Discussioncontrasting

confidence: 99%

“…[1][2][3][4] In addition, pentobarbital has been shown to produce long-lasting changes in synaptic transmission in the hippocampus. 5,6 The latter effect shares many characteristics with conventional hippocampal synaptic plasticity.…”

Section: Discussionmentioning

confidence: 99%

Pentobarbital induces nocifensive hyperrflexia, not hyperalgesia in rats

Archer

Samanani

Roth

2000

Can J Anesth/J Can Anesth

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“…The SBP (mean 5: SD mmHg) and the heart rate (mean 5: SD beats/rnin) in control, ephedrine and volume loading groups were 120 5:15. 3 Figure 1). This pattern changed with pretreatment with ephedrine sulphate and with pre4nduction loading with Ringer's lactate (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation

et al. 1995

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“…1.2o One possible contributory factor is that propofoi is not antanalgesic compared with thiopentone. 21 Trends in haemodynamic variables during maintenance of anaesthesia are difficult to evaluate during Caesarean section. The non-standardized influences on blood pressure and heart rate include circulatory changes at delivery, blood loss and fluid replacement.…”

Section: Discussionmentioning

confidence: 99%

Propofol infusion anaesthesia for Caesarean section

et al. 1990

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Propofol infusions for the maintenance of anaesthesia during Caesarean section may offer some advantages. Recovery from propofol infusion is rapid 1-5 and this would be desirable for mothers who are still at risk from acid aspiration in the postoperative period. The rapid recovery characteristics of propofol may also be beneficial for the neonate after delivery. However, placental transfer of propofol is rapid 6 and infusions present the fetus with a large dose of drug which may cause neonatal depression after delivery. Decreases in blood pressure after propofol have been reported, 7 and often to a greater degree than with thiopentone, s'9 This could be detrimental to placental perfusion and neonatal outcome. Nevertheless, studies during maintenance of anaesthesia show similar haemodynamic profiles in patients given propofol infusions compared with inhalational agents. 1.2,4High inspired maternal oxygen concentrations may be beneficial for the fetus at risk of intrauterine asphyxia, i0 A propofol infusion may permit the use of 100 per cent oxygen without risk of maternal awareness or the need for higher concentrations of volatile agent.This study evaluated propofol infusions for Caesarean section. Two different infusion regimens and a standard thiopentone, enflurane and nitrous oxide general anaesthetic were compared. One infusion regimen substituted CAN J ANAESTH 1990 / 37:5 / pp 514-20

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Comparison of the Effect of Diisopropyl Phenol (Ici 35 868) and Thiopentone on Response to Somatic Pain

Cited by 76 publications

References 10 publications

Pentobarbital induces nocifensive hyperrflexia, not hyperalgesia in rats

Pentobarbital induces nocifensive hyperrflexia, not hyperalgesia in rats

Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation

Propofol infusion anaesthesia for Caesarean section

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