Comparison of the Effect of Tea Tree Oil Shampoo With Regular Eyelid Shampoo in Meibomian Gland Dysfunction Treatment

Zarei‐Ghanavati, Siamak; Nooghabi, Mehdi Jabbari; Zamani, Ghodsieh

doi:10.1016/j.ajo.2021.04.009

Cited by 9 publications

(10 citation statements)

References 26 publications

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“…Nine studies were published in the field of infectious disease addressing hand disinfection [n = 3; (Gnatta et al, 2013;Gnatta et al, 2021;Youn et al, 2021)], MRSA decolonization [n = 4; (Caelli et al, 2000;Dryden et al, 2004;Blackwood et al, 2013;Lee et al, 2014)] or prevention of MRSA colonization [n = 1; (Blackwood et al, 2013)], molluscum contagiosum [n = 1; (Markum and Baillie, 2012)], or oral Candida infection [n = 1; (Maghu et al, 2016)]. Six studies were published in the field of ophthalmology addressing Demodex infestation [n = 4; (Koo et al, 2012;Karakurt and Zeytun, 2018;Wong et al, 2019;Craig et al, 2022)], dry eye post cataract surgery [n = 1; (Mohammadpour et al, 2020)], or meibomian gland dysfunction [n = 1; (Zarei-Ghanavati et al, 2021)]. Three studies were published in the field of podiatry addressing onychomycosis [n = 1; (Buck et al, 1994)], or tinea pedis [n = 2; (Tong et al, 1992;Satchell et al, 2002b)].…”

Section: Characteristics Of Included Trialsmentioning

confidence: 99%

“…Six trials were published in the field of ophthalmology from 2012 to 2021, and were conducted in Australia (Wong et al, 2019), Canada (Craig et al, 2022), Iran (Mohammadpour et al, 2020;Zarei-Ghanavati et al, 2021), Korea (Koo et al, 2012), or Turkey (Karakurt and Zeytun, 2018), within the hospital or outpatient clinic setting.…”

Section: Ophthalmologymentioning

confidence: 99%

“…All other outcomes assessed showed no significant difference between groups (Table 4). Adverse events were measured in three of the five ophthalmology trials (Koo et al, 2012;Wong et al, 2019;Zarei-Ghanavati et al, 2021). Ocular irritation was the main side effect of tea tree oil use reported by 5/106 subjects using a tea tree oil-based mineral oil solution (Koo et al, 2012) and 21/ 40 subjects using tea tree oil-based Eyesol ® shampoo (compared with 12/40 reporting this symptom from use of baby shampoo) (Zarei-Ghanavati et al, 2021).…”

Section: Demodex Infestationmentioning

confidence: 99%

“…Adverse events were measured in three of the five ophthalmology trials (Koo et al, 2012;Wong et al, 2019;Zarei-Ghanavati et al, 2021). Ocular irritation was the main side effect of tea tree oil use reported by 5/106 subjects using a tea tree oil-based mineral oil solution (Koo et al, 2012) and 21/ 40 subjects using tea tree oil-based Eyesol ® shampoo (compared with 12/40 reporting this symptom from use of baby shampoo) (Zarei-Ghanavati et al, 2021). Further, 1/20 subjects using Blephadex ™ eyelid wipes reported slight discomfort upon initial use which later resolved (Wong et al, 2019).…”

Section: Demodex Infestationmentioning

confidence: 99%

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Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

et al. 2023

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Introduction: Leaves of the Australian tea tree plant Melaleuca alternifolia were used traditionally by First Nations Australians for treating wounds, burns, and insect bites. Tea tree oil, the essential oil steam-distilled from M. alternifolia, is well-known for its medicinal properties, the evidence for most applications however is limited. This review aimed to critically appraise evidence from clinical trials examining the therapeutic efficacy and safety of tea tree oil on outcomes.Methods: Randomized controlled trials with participants of any age, gender, or health status, comparing tea tree oil to any control were included, without limit on publication date. Electronic databases were searched on 12 August 2022 with additional records sourced from article reference sections, reviews, and industry white papers. Risk of bias was assessed by two authors independently using the Cochrane risk-of-bias 1.0 tool. Results were summarized and synthesized thematically.Results: Forty-six articles were eligible from the following medical fields (Dentistry n = 18, Dermatology n = 9, Infectious disease n = 9, Ophthalmology n = 6, Podiatry n = 3; and Other n = 1). Results indicate that oral mouthwashes with 0.2%–0.5% tea tree oil may limit accumulation of dental plaque. Gels containing 5% tea tree oil applied directly to the periodontium may aid treatment of periodontitis as an adjunctive therapy to scaling and root planing. More evidence is needed to confirm the benefits of tea tree oil for reducing acne lesions and severity. Local anti-inflammatory effects on skin, if any, also require further elucidation. Topical tea tree oil regimens show similar efficacy to standard treatments for decolonizing the body from methicillin-resistant Staphylococcus aureus, although intra-nasal use of tea tree oil may cause irritation to mucous membranes. Tea tree oil with added iodine may provide an effective treatment for molluscum contagiosum lesions in young children. More evidence on efficacy of tea tree oil-based eyelid wipes for Demodex mite control are needed. Side effects were reported in 60% of included studies and were minor, except where tea tree oil was applied topically in concentrations ≥ 25%.Discussion: Overall, the quality of research was poor to modest and higher quality trials with larger samples and better reporting are required to substantiate potential therapeutic applications of tea tree oil.Systematic Review Registration: PROSPERO, identifier [CRD42021285168].

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Section: Characteristics Of Included Trialsmentioning

confidence: 99%

Section: Ophthalmologymentioning

confidence: 99%

Section: Demodex Infestationmentioning

confidence: 99%

Section: Demodex Infestationmentioning

confidence: 99%

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Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

et al. 2023

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“…The patients exhibited one or more clinically significant signs of MGD, such as meibomian gland capping or dropout, lid telangiectasia, redness, irregularity. The above signs are known to most common clinically observable pathognomic signs of MGD [15] . And patients have similar symptoms of DES, such as ocular irritation, glare, dryness, excessive tears, itching, pain, and fluctuating visual acuity.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Clinical efficacy of 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

Jo¹,

Lee²

2022

Int J Ophthalmol

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AIM: To evaluate the clinical efficacy of topical 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome (DES) with meibomian gland dysfunction (MGD). METHODS: This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups: Group 1 (n=24, conventional cyclosporine), Group 2 (n=21, nano-emulsion cyclosporine), and Group 3 (n=19, control). Lid margin telangiectasia (LMT), meibomian gland secretion (MGS), conjunctival injection (CI), corneal staining (CS), tear break-up time (TBUT), Schirmer test I (STI), Ocular Surface Disease Index (OSDI), and lipid layer thickness (LLT) was evaluated at 4, 8, and 12wk of treatment. RESULTS: In Group 3 (control), LMT, CS, and CI improved after 8wk, MGS, TBUT after 12wk of treatment. In Group 1 (conventional cyclosporine), LMT, MGS, and TBUT improved significantly after 4wk, whereas CS, CI, STI, and LLT improved significantly after 8wk, and OSDI at 12wk. In Group 2 (nano-cyclosporine), LMT, MGS, CS, CI, TBUT, and OSDI significantly improved after 4wk, and STI after 8wk. Especially, LLT was significantly higher than other groups after 4wk. CONCLUSION: Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control group. In contrast, the nano-cyclosporine group shows more statistically improved CI and CS at 4wk, especially LLT at 4, 8, and 12wk compared to the conventional cyclosporine group.

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Obtaining PCL/tea tree oil particles with antimicrobial capacity and high cytocompatibility

Ferreira,

de Menezes,

Tavares

2024

Polym. Bull.

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Comparison of the Effect of Tea Tree Oil Shampoo With Regular Eyelid Shampoo in Meibomian Gland Dysfunction Treatment

Cited by 9 publications

References 26 publications

Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

Clinical efficacy of 0.05% cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

Obtaining PCL/tea tree oil particles with antimicrobial capacity and high cytocompatibility

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