Comparison of the Effect on Vessel Density and RNFL between Carteolol and Latanoprost

Abstract

The aim of the study was to compare the treatment of hypertensive glaucoma (HTG) in the early stages with carteolol and latanoprost by assessing the change in vessel density (VD) and retinal nerve fibre layer (RNFL). Methods: The first group with diagnosed HTG consisted of 46 eyes treated with carteolol; the second group consisted of 52 eyes treated with latanoprost. The following examinations were evaluated in all patients: intraocular pressure (IOP), retinal nerve fibre layer (RNFL), vessel density (VD) and visual field examination (glaucoma fast threshold test). The results were compared before treatment and 3 months after treatment. Results: There was no difference in the overall visual field defect (OD) between groups before treatment. After treatment, there was a decrease in IOP in both groups (carteolol-treated group had a mean decrease of 5.8 mmHg and latanoprost-treated eyes had a mean decrease of 7 mmHg). This difference was not statistically significant (p = 0.133). No similar difference was observed for RNFL (p = 0.161). In contrast, the change in the VD parameter was statistically significant between groups (p < 0.05), with a greater difference observed in the carteolol-treated group of eyes. Carteolol had a better effect on the VD.

Effect of treatment with carteolol and latanoprost in newly diagnosed primary open-angle glaucoma on peripapillary vessel density

“…In another study, we demonstrated a statistically significant improvement in VD of small and all vessels both peripapillary and whole image in eyes treated with carteolol. We found no statistically significant change with latanoprost 17 .…”

“…In our previous work, where we evaluated peripapillary vessel density of all vessels, peripapillary vessel density of small vessels, vessel density of all vessels of the whole image and vessel density of small vessels of the whole image between the carteolol and latanoprost treated groups, we found a statistically significant difference only in the carteolol group 17 .…”

The impact of intraocular pressure on optical coherence tomography angiography: A review of current evidence

“…Forty-five manuscripts met the inclusion and exclusion criteria and were divided into six groups[ 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 ] based on the primary intervention category [ Table 1 ]. Thirteen studies involved IOP reduction and glaucoma surgery.…”

“…[ 25 26 27 28 29 30 31 32 33 34 35 36 37 ] Nine studies involved IOP reduction and specific ophthalmic drops. [ 12 13 14 15 16 17 18 19 20 ] Nine studies examined the impact of diurnal IOP variability on OCTA. [ 3 4 5 6 7 8 9 10 11 ] Four involved IOP changes related to glaucoma lasers[ 21 22 23 24 ] and three studies examined the effect of cataract surgery on IOP and OCTA.…”

“…Studies involving eye drops for the treatment of glaucoma or ocular hypertension were frequently limited by small sample sizes, but the data suggest potential future considerations. Although beta blocker drops were shown to increase superficial peripapillary VD (ppVD) in new primary open-angle glaucoma patients,[ 20 ] two reports suggested that beta blocker drop use may be associated with attenuated superficial VD in normal tension glaucoma patients. [ 16 17 ] Although not entirely conclusive, this supports the findings of the Low-Pressure Glaucoma Treatment Study that favored brimonidine over timolol in normal tension glaucoma patients.…”