Comparison of the Effectiveness of Proton and Photon Therapy in Patients With Brain Tumors

Abstract

Owing to the development of molecular genetics, the role of radiation therapy and chemotherapy in treatment of patients with glioma (WHO Grade I–IV) has become more understandable. The overall survival among glioma patients has increased. As overall survival increases, oncologists are more likely to detect manifestations of late radiation toxicity that has a huge impact on Quality of Life in patients who have undergone radiation therapy in the past. In this regard, the question of finding more adequate radiation therapy techniques remains relevant. photon radiation therapy is the standard method; however, considering dosimetric advantages of proton therapy over photon therapy, its widespread use can potentially lead to the increased overall survival, decreased number of late radiation-induced complications and improved quality of life in the post-radiation period. This article presents some comparative characteristics of proton and photon radiation therapy in patients with gliomas (WHO Grade I–IV). dosimetry characteristics of protons in tissues were compared, data showing differences in survival of patients treated with photons versus patients treated with protons were presented, and general information on early and late radiation-induced toxicity arising from the treatment by these methods was disclosed.

Proton therapy in pediatric neuro-oncology. Potential advantages and the relationship between cost and results

“…Максимум энергии пучка отдается в этом пике, до него доза отдаваемой тканям энергии минимальна, а после него практически равна нулю. Такое свойство протонов позволяет максимально ограничить степень облучения окружающих опухоль тканей, что актуально в практике детской онкологии, особенно при внутричерепных опухолях мозга [8].…”

“…Для отечественной онкологии терапия УП является относительно новым вариантом ЛТ, и протонными ускорителями располагают только несколько учреждений в стране. Тем не менее в отечественной литературе есть ряд публикаций, освещающих отечественный и зарубежный опыт применения УП в онкологической практике [6][7][8][9]. К настоящему времени уже накоплен значительных опыт использования данного вида излучения, в том числе и в практике онкопедиатрии при различных нозологических формах опухолей [10,11].…”

Radiosensitizing Effect of Dextran-Coated Iron Oxide Nanoparticles on Malignant Glioma Cells

“…Gliomas are primary tumors of the nervous system that arise from transformed neuroglial cells, accounting for about 26.6% of all brain tumors. The most aggressive and common among them is glioblastoma (adult-type diffuse glioma, IDH-wild, CNS WHO grade IV in accordance with the 2021 World Health Organization Classification of Tumors of the Central Nervous System) [1][2][3]. The standard treatment for glioblastomas involves surgical removal of tumor foci accessible for surgery, followed by irradiation and administration of the alkylating drug temozolomide.…”

“…This feature of such a type of irradiation is called the Bragg curve, which represents the dependence of the absorbed dose on the penetration depth of the beam. The maximum of this curve is called the Bragg peak and depends on the initial proton energy [2,7,8]. After passing the maximum, the value of the absorbed dose drops sharply to zero.…”