Comparison of the effectiveness of depot antipsychotics in routine clinical practice

Shajahan, Polash; Spence, E.; Taylor, Mark; Daniel, Darlington; Pelosi, Anthony

doi:10.1192/pb.bp.109.026849

Cited by 11 publications

(14 citation statements)

References 16 publications

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“…The result is at odds with the only randomized head-to-head comparison that has been performed for these drugs [Rubio et al 2006], in which risperidone LAI performed better on several measures, including the PANSS total score. A retrospective observational study [Shajahan et al 2010], however, that compared several LAIs (risperidone, zuclopenthixol and flupenthixol) found longer time to discontinuation and lower hospitalization rates for patients treated with zuclopenthixol LAI. Also relevant is the finding in a large effectiveness study that another medium-potent oral FGA (perphenazine) was found to have a comparable effectiveness to several SGAs [Lieberman et al 2005].…”

Section: Lai Antipsychotics Versus Olanzapine Oralmentioning

confidence: 99%

Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies

Kroken

Kjelby

Wentzel‐Larsen

et al. 2014

Therapeutic Advances in Psychopharmacology

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Background: Rates of discontinuation of antipsychotic treatment for patients with schizophrenia are high and evidence is limited by selective inclusion and high attrition in randomized controlled trials. Aims: To study time to discontinuation of antipsychotic treatment for patients with schizophrenia. Method: All patients with schizophrenia (n = 396) discharged between 2005 and 2011 were followed until discontinuation (clinician or patient decided) of antipsychotic treatment or other endpoints. Univariate and multivariate survival analyses (with time on antipsychotic treatment as the dependent variable) using time-dependent variables were performed. Results: Clozapine displayed lower risk for all-cause (p < 0.001), clinician-decided (p = 0.012) and patient-decided (p = 0.039) discontinuation versus olanzapine oral treatment in the multivariate Cox regression. Second-generation long-acting injection antipsychotics (LAI) (p = 0.015) and first-generation long-acting injection antipsychotics (p = 0.013) showed significantly lower risks for patient-decided discontinuation than olanzapine oral. Conclusion: Higher effectiveness of clozapine and LAI treatment versus oral olanzapine were identified in a clinical cohort of patients with schizophrenia.

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Section: Lai Antipsychotics Versus Olanzapine Oralmentioning

confidence: 99%

Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies

Kroken

Kjelby

Wentzel‐Larsen

et al. 2014

Therapeutic Advances in Psychopharmacology

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“…In addition, clinical global impression scale (CGI) [10] severity and improvement subscales were retrospectively assigned at the time of initial detoxification, and after 2 years. Such retrospective assignment has been performed by others in assessing treatment response [11]. Patient records were examined by scrutinising case records and computer based patient information systems to monitor subsequent progress over a 2 year period.…”

Section: Methodsmentioning

confidence: 99%

Effects of Comorbid Opiate Dependency on Patients Admitted for Alcohol detoxification: Retrospective Chart Review and 2 Year Outcome

Ahmad¹

2013

J Addict Res Ther

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IntroductionWorldwide alcohol related harm and dependence caused 4% of the global disease burden and the proportion is greatest in Europe and America [1]. The level of alcohol dependence in the UK population is 4% [2] but levels are much higher in opiate users for example 20-40% of patients undergoing opiate replacement therapy had alcohol dependence [3][4][5][6].There is evidence to suggest that chronic alcohol abuse is an important cause of medical complications during methadone treatment [7], which is frequently linked to premature discharge from treatment [8] and is associated with increased mortality rates [9]. Individuals with opiate dependence are at increased risk of developing Hepatitis C infection, the majority of which remain undiagnosed [9] and alcohol abuse further exacerbates disease progression.Within our locality, it was noted that a significant population requiring inpatient alcohol detoxification were also receiving opiate replacement therapy (ORT). We aimed to compare the outcomes of patients requiring alcohol detoxification not on ORT with those on ORT. MethodThis was a retrospective study comparing characteristics of patients requiring an alcohol detoxification with those who required an alcohol detoxification who were also on opiate replacement therapy. The data was collected over a 2 year period from the index episode of inpatient alcohol detoxification.Patients admitted for the first time for alcohol detoxification to our local acute psychiatric unit between the period of November 2003 and December 2006, were identified. Clinical and demographic details were extracted from their case records. In addition, clinical global impression scale (CGI) [10] severity and improvement subscales were retrospectively assigned at the time of initial detoxification, and after 2 years. Such retrospective assignment has been performed by others in assessing treatment response [11]. Patient records were examined by scrutinising case records and computer based patient information systems to monitor subsequent progress over a 2 year period. This included contact with medical or surgical wards, accident and emergency departments or psychiatric services within the local NHS (Lanarkshire) Health Board authority. The following clinical variables were recorded; time taken from the initial detoxification admission to the next admission (medical or psychiatric), whether admissions were planned, for example, a further detoxification, or were unplanned, patient's daily alcohol consumption (units per day) and whether patients were still engaged with psychiatric or addiction services at the end of the 2 year follow up period. It was also noted whether formal discharge from psychiatric or addiction services was planned or unplanned. The rationale for this being that planned discharges from psychiatric or addiction services were considered to be a positive health outcome indicating stability or recovery from addiction. Table 1 illustrates characteristics of those who required an alcohol detoxification (n=64) and those who...

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“…La evidencia de si los APD aumentan la adherencia y disminuyen las recaí-das y rehospitalizaciones no es consistente 3,[7][8][9] . Hay estudios que muestran que los APD pueden aumentar la tasa de adherencia en pacientes con esquizofrenia 7,10 , pero el aumento de adherencia no necesariamente se refleja en una disminución significativa de las tasas de recaída o rehospitalización en el largo plazo 9 .…”

Section: Introductionunclassified

Tratamiento con antipsicóticos de depósito del paciente adulto con diagnóstico de esquizofrenia

González

Restrepo

Valencia

et al. 2014

Revista Colombiana de Psiquiatría

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Comparison of the effectiveness of depot antipsychotics in routine clinical practice

Cited by 11 publications

References 16 publications

Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies

Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies

Effects of Comorbid Opiate Dependency on Patients Admitted for Alcohol detoxification: Retrospective Chart Review and 2 Year Outcome

Tratamiento con antipsicóticos de depósito del paciente adulto con diagnóstico de esquizofrenia

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