Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: A meta-analysis

Grutters, Janneke P.C.; Kessels, Alfons G.H.; Pijls‐Johannesma, Madelon; Ruysscher, Dirk De; Joore, Manuela A.; Lambin, Philippe

doi:10.1016/j.radonc.2009.08.003

Cited by 292 publications

(167 citation statements)

References 71 publications

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“…carbon ions in treating NSCLC [Grutters et al, 2010]. They found similar 5-year survival rates for SBRT, protons and carbon-ions (around 40%).…”

Section: Grutters Et Al Have Performed a Meta-analysis On Comparisonmentioning

confidence: 85%

“…A stereotactic body radiation treatment (SBRT) shows good results for treating NSCLC [Baumann et al, 2009, Fakiris et al, 2009, Grutters et al, 2010, Greco et al, 2011. Furthermore, several studies have shown that SBRT can be used in the setting of limited metastatic disease [Rusthoven et al, 2009, Villaruz et al, 2012, Salama et al, 2012, Iyengar et al, 2014.…”

Section: Introductionmentioning

confidence: 99%

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In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

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Stereotactic body image guided radiation therapy (SBRT) shows excellent results for the local control of early stage lung cancer. However, not all patients are eligible for SBRT, and advanced stage treatment is less successful and often associated with severe side effects. Scanned carbon ion therapy (PT) can deliver more conformal dose likely benefiting these patient groups.Therefore an in silico trial was conducted on early and advanced stage patients to identify potential advantages of PT. The patients were treated with SBRT at Champalimaud Center for the Unknown, Lisbon (Portugal). PT plans were simulated on 4DCTs, and rescanning was investigated for motion mitigation in 4D-dose calculations. A dedicated strategy for 4D intensity modulated particle therapy (IMPT) was developed and applied for advanced stage patients with multiple lesions. For clinically valid and reliable results the deformable image registrationnecessary for 4D-dose calculation -a quality assurance tool was developed and applied in the study.The results showed that target coverage was comparable in SBRT and PT, while PT delivered significantly lower doses to most critical structures, especially the heart, lungs, and esophagus.A highly complex case of advanced stage lung cancer could be treated in a single fraction of 24 Gy with PT, while SBRT could not deliver the full ablative dose treatment due to an excessive heart dose. The mean heart dose was reduced from 10 Gy to 0.8 Gy with PT for this specific patient.

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“…carbon ions in treating NSCLC [Grutters et al, 2010]. They found similar 5-year survival rates for SBRT, protons and carbon-ions (around 40%).…”

Section: Grutters Et Al Have Performed a Meta-analysis On Comparisonmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

et al. 2016

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“…A meta-analysis by Grutters et al showed that the OS at 5 years for SBRT and conventional radiotherapy were 42.1% and 19.5%, respectively [4]. The introduction of SBRT in the treatment of elderly NSCLC patients is associated with an improvement in OS, as shown by Palma et al.…”

Section: Introductionmentioning

confidence: 93%

“…Stereotactic body radiation therapy (SBRT) for peripheral stage I non-small cell lung cancers (NSCLC) is recognized as a standard treatment for medically inoperable patients [1][2][3][4][5][6]. Nagata et al reported that the overall survival (OS) for stage IA and IB NSCLC patients at 3 years were 83% and 72%, respectively [1].…”

Section: Introductionmentioning

confidence: 99%

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV < 100 cc using a continual reassessment method (JCOG0702)

Onimaru

Shirato

Shibata

et al. 2015

Radiotherapy and Oncology

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Key Words: phase I study, continual reassessment method, non-small cell lung cancer (NSCLC), stereotactic body radiotherapy, SBRT. Short running title: Previous presentationThis work was presented at the 55th Annual Meeting of the American Society for Radiation Oncology, September 22 -25, 2013 in Atlanta, GA. / 28Abstract Purpose: To estimate the maximum tolerated dose (MTD) and to determine the recommended dose (RD) of stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinoma (NSCLC) with target volume (PTV) < 100 cc. Materials and Methods:The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the MTD. Dose limiting toxicity (DLT) was grade 3 radiation pneumonitis (RP) within 180 days after the start of SBRT, grade 2 RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D 95 of the PTV.Results: Fifteen patients were accrued. Only 1 experienced grade 2 RP at 60 Gy in 4fractions. It was difficult to fulfill the dose constraints at 60 Gy in 4 fractions, and the maximum dose level assigned by CRM was changed to 55 Gy in 4 fractions. The lower limit of 95% of the credible interval exceeded the adjacent level, and the RD was determined as 55 Gy in 4 fractions. Conclusions:The RD of SBRT for peripheral T2N0M0 NSCLC with PTV < 100 cc was determined to be 55 Gy in 4 fractions. / 28

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“…However, these studies were small and most were retrospective. Therefore, a meta-analysis was performed to compare the efficacy of chemoradiotherapy, photon SBRT, PBT and carbon ion therapy for stage I inoperable NSCLC [23]. Carbon ion therapy is one of the particle radiotherapies, as well as PBT, but carbon ion beams are categorized as high LET radiation.…”

Section: Clinical Results Of Pbt For Early Stage Non-small-cell Lung mentioning

confidence: 99%

The use of proton-beam therapy in the treatment of non-small-cell lung cancer

Oshiro¹,

Sakurai

2013

Expert Review of Medical Devices

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Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: A meta-analysis

Abstract: Survival rates for particle therapy were higher than those for CRT, but similar to SBRT in stage I inoperable NSCLC. Particle therapy may be more beneficial in stage III NSCLC, especially in reducing adverse events.

Cited by 292 publications

References 71 publications

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

In silico comparison of photons versus carbon ions in single fraction therapy of lung cancer

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV < 100 cc using a continual reassessment method (JCOG0702)

The use of proton-beam therapy in the treatment of non-small-cell lung cancer

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