Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial second-degree burns. Randomised clinical trial

Abstract

Background: Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychological sequelae. The aim of this study was to compare the effectiveness of Aloe Vera gel with 2%Nitrofurazone ointment in the healing of superficial partial thickness burns wounds. Methods: The present study was a split body controlled, randomized clinical trial. The sample was recruited from patients with superficial partial thickness burns wound who were prescribed to treat with 2% Nitrofurazone ointment. Thirty patients with at least two burn, each burn on an alternate side of the body, entered the study — samples allocated to two area which received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound. assessment tool (BWAT) was used to evaluate the healing of burns. the epithelialization parameter and sum score Bates-Jensen tools evaluated before, one, two and three weeks after the beginning of treatment. Results: The mean ± SD of epithelialization parameter in Aloe Vera area were 5.0±00.00, 4.0±46.57, 3.0±50.57, 2.0±56.62. The mean ± SD of epithelialization parameter in 2% Nitrofurazone ointment area were 5.0±00.00, 4.0±66.54, 3.0±76.50, 3.0±03.61.and The mean ± SD of BWAT scores in Aloe Vera area were 30.32 ± 3.28, 27.33 ± 3.38, 21.33 ± 3.13, 16.12 ± 2.16 respectively (F(2, 65.07) =440.00, p=0.001). The mean ± SD of BWAT scores in 2% Nitrofurazone ointment area were 30.51 ± 3.79, 28.45 ± 3.49, 23.36 ± 2.89, 19.23 ± 2.11 ( F(1, 52.00) =228.00, p=0.001).Conclusions: There is a significant difference in epithelialization parameter and (BWAT) scores between intervention and control area. Based on this study it looks like that aloe vera gel could promoted epithelialization and wound closure more effectively than 2% Nitrofurazone ointment

A Bibliometric Analysis of Aloe vera in Wound Healing

“…According to the title of the most recent paper from the top seven institutions, clinical evaluation has been reached. In a randomized clinical trial study, A. vera gel promoted epithelialization and wound healing of partialthickness superficial burns more effectively than 2% Nitrofurazone ointment (Varaei et al, 2020).…”