2009
DOI: 10.1016/j.tox.2009.01.007
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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

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Cited by 48 publications
(66 citation statements)
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References 24 publications
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“…We have provided some experimental data showing a key species difference; those were that while PB stimulates replicative DNA synthesis in rodent hepatocytes, such proliferative effects are not observed in cultured human hepatocytes (Yamada et al, 2015;Hirose et al, 2009) nor in human hepatocytes of chimeric mice (Yamada et al, 2014). The lack of this key event in humans strongly supports the previous conclusion that the rodent carcinogenicity by CAR activators such as PB is not relevant to humans based on experimental and epidemiology data .…”
Section: Epsilon-momfluorothrinsupporting
confidence: 66%
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“…We have provided some experimental data showing a key species difference; those were that while PB stimulates replicative DNA synthesis in rodent hepatocytes, such proliferative effects are not observed in cultured human hepatocytes (Yamada et al, 2015;Hirose et al, 2009) nor in human hepatocytes of chimeric mice (Yamada et al, 2014). The lack of this key event in humans strongly supports the previous conclusion that the rodent carcinogenicity by CAR activators such as PB is not relevant to humans based on experimental and epidemiology data .…”
Section: Epsilon-momfluorothrinsupporting
confidence: 66%
“…Rat hepatocytes were isolated by a two-step perfusion procedure from HarlanRccHanTM:WIST male rats aged 10 weeks (purchased from Japan Laboratory Animals, Inc., Hanno Breeding Center, Saitama, Japan) (Hirose et al, 2009;Yamada et al, 2015). Viability (range 80-92%) was determined by trypan blue exclusion.…”
Section: Cultured Hepatocyte Study Hepatocytesmentioning
confidence: 99%
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“…This observation is based on the resistance of cultured human hepatocytes to induction of replicative DNA synthesis (Hirose et al 2009;Lake 2009;Parzefall et al 1991) as well as similar observations in huPXR/huCAR receptor humanized mice.…”
Section: Epidemiology and Risk To Manmentioning
confidence: 83%