Comparison of the Effects of Ticagrelor and Clopidogrel on Inflammatory Factors, Vascular Endothelium Functions and Short-Term Prognosis in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention: a Pilot Study

Abstract

Background/Aims: Acute ST-segment elevation of myocardial infarction (STEMI) is the most severe type of acute coronary syndrome (ACS). Particular attention has been focused on studying the pathogenesis of STEMI, and how to prevent thrombosis, reduce inflammatory reaction, stabilize plaques and improve vascular endothelial functions to preserve the survived myocardium. This study aimed to compare the anti-inflammatory endothelium-protective effects, clinical prognosis, and relevant bleeding risks of ticagrelor versus clopidogrel in patients with STEMI who underwent urgent percutaneous coronary intervention (PCI) and provide certain experimental evidence and a theoretical basis for the selection of safe and effective drugs and their proper dosage, thereby further guiding clinical medication. Methods: We sequentially enrolled 193 patients (104 males and 89 females) admitted to hospital due to acute STEMI. These patients underwent urgent PCI between December 2013 and May 2015 and met the inclusion criteria. They were assigned (1: 1) into two groups according to different treatments, 97 patients in the ticagrelor group (treatment group), and 96 patients in the clopidogrel group (control group). Levels of hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and endothelial cell-specific molecule 1 (ESM-1) taken at admission and 24 h, 4 days, and 7 days after administration, as well as the correlation between the levels of IL-6, hs-CRP, and ESM-1, were determined in the two groups. At the same time, the effects of treatment with ticagrelor and clopidogrel on the efficacy endpoint events (ischemic and safety) were explored. Results: No statistically significant difference was found in the levels of hs-CRP, IL-6, or ESM-1 at admission between the two groups (P> 0.05); Their levels were significantly elevated 24 h after administration, with statistical differences between two groups (P< 0.05). Furthermore, a downward trend with statistically significant differences was found on Day 4 and Day 7 (P< 0.05); ESM-1 levels increased along with increases of hs-CRP and IL-6 levels, indicating ESM-1 was positively correlated with hs-CRP (r=0.523, P< 0.001) and IL-6 (r=0.431, P< 0.001); and the occurrence rates of ischemic endpoint events at 30 days were lower in the treatment group than in the control group. The occurrence of safety endpoint events was higher than in the control group; however, no statistically significant difference was found (P> 0.05). Conclusions: Compared with clopidogrel, ticagrelor appears to rapidly reduce the prevalence of inflammatory reactions and stabilize the functions of vascular endothelium to improve the stability of atherosclerotic plaque and decrease the occurrence rate of thrombosis as well as ischemic outcome events without any obvious increase in the risk of bleeding in patients with acute STEMI receiving urgent PCI. This renders it a potential drug for clinical practice. At the same time, measurement of ESM-1, a new biological marker for vascular endothelial function disorder, coul...

Short-term efficacy of ticagrelor in acute ST-segment elevation myocardial infarction patients undergoing an emergency percutaneous coronary intervention

“…In our previous study, we reported that ticagrelor decreased the occurrence rate of thrombosis, as well as ischemic outcome events, without causing any obvious increase in the risk of bleeding in acute STEMI patients receiving urgent percutaneous coronary intervention (PCI) [15]. In this study, we investigated the short-term efficacy (platelet inhibition) of ticagrelor and clopidogrel in acute ST-segment elevation myocardial infarction (STEMI) patients undergoing an emergency percutaneous coronary intervention (PCI).…”

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

“…hs-CRP is considered as a risk factor of cardiovascular diseases and can increase the mortality of cardiovascular diseases 14,15 . CRP is involved in the pathogenesis and development of vascular in ammation and coronary atherosclerosis 16 .It directly affects complement activation, apoptosis, vascular cell activation, monocyte recruitment, lipid accumulation, and thrombosis and other atherosclerotic processes 17,18 . Epidemiological meta-analysis showed that hs-CRP > 3.0 mg/dL compared to < 1.0 mg/dL increased the risk of CAD by 1.6 times, and the hs-CRP levels were positively associated with the severity of coronary heart disease, which increase with the increase of lesion count 19 .…”

The Biomarkers for Acute Myocardial Infarction and Heart Failure

“…Endothelial cellspecific molecule 1 (ESM-1), also known as endocan, is a biomarker for endothelial dysfunction [103] and may serve as a novel evaluation method for risk stratification of patients with acute STEMI [104]. Another study also demonstrated that high endocan level at presentation was an independent predictor for adverse cardiac events [105,106].…”