Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats.

Pryce, Christopher R.; Bettschen, Daniela; Nanz-Bahr, Nina I.; Feldon, Joram

doi:10.1037/0735-7044.117.5.883

Cited by 119 publications

(65 citation statements)

References 61 publications

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“…In a previous longitudinal study in Wistar rats (Pryce, Bettschen, Bahr, & Feldon, 2001a;Pryce et al, 2001b;Pryce, Bettschen, Nanz-Bahr, & Feldon, 2003), we demonstrated, somewhat unexpectedly, that an apparently severe rat postnatal manipulation-4-hr maternal and littermate deprivation per day between birth and weaning (early deprivation, ED) during the dark phase of a reversed light:dark cycle and at an ambient temperature of 30 C-results in adult offspring with enhanced coping ability relative to complete nondisturbance between birth and weaning, i.e., nonhandling (NH). In fact, the ED offspring were similar to those exposed as pups to brief daily isolations, i.e., early handling (EH), a manipulation that actually increases maternal care across the daily cycle (Lee & Williams, 1974;Liu et al, 1997;Pryce et al, 2001b).…”

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confidence: 99%

Circadian‐ and temperature‐specific effects of early deprivation on rat maternal care and pup development: Short‐term markers for long‐term effects?

Rüedi‐Bettschen

Feldon

Pryce

2004

Developmental Psychobiology

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We compare the effects on pup body weight and on maternal care of 4-hr separation from dam and littermates on postnatal Days 1 to 14 (early deprivation, ED) under different thermal and circadian conditions. ED was performed at either 21 degrees C (Cold), or 32 degrees C (Warm), and either during the light or dark phase. The comparison group was nonhandling (NH), either under a nonreversed (Light) or reversed (Dark) cycle. At weaning, Cold ED pups were of lower body weight than Warm ED pups, and Warm ED pups were of lower body weight than NH pups. Light and Dark ED pups received high care at reunion relative to NH, and Cold ED pups received higher care at several hours postreunion relative to Warm ED and NH pups. We propose that reduced pup weight and increased maternal care are short-term markers for the severity of Cold ED, and that this manipulation could therefore impact negatively on emotionality and cognition in adulthood.

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confidence: 99%

Circadian‐ and temperature‐specific effects of early deprivation on rat maternal care and pup development: Short‐term markers for long‐term effects?

Rüedi‐Bettschen

Feldon

Pryce

2004

Developmental Psychobiology

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“…Yet, a recent study showed that male mice exposed to juvenile stress froze less during fear conditioning training and extinction when the animals were tested before puberty (Peleg-Raibstein & Feldon, 2011) but not when fear conditioning was performed in adulthood. Other early life manipulations (neonatal maternal separation and handling) often lead to impairment in fear conditioning in adulthood (Kosten, Nanz-Bahr, & Feldon, 2003). Interestingly, these sex differences on the impact of stress also expand to other forms of learning, although the effects are reversed for cued and spatial learning.…”

Section: Peri-pubertal Stress Has a Sex-dependent Effect On Extinctiomentioning

confidence: 99%

Stress during puberty boosts metabolic activation associated with fear-extinction learning in hippocampus, basal amygdala and cingulate cortex

Toledo-Rodriguez

Paus

Sandi

2012

Neurobiology of Learning and Memory

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a b s t r a c tAdolescence is characterized by major developmental changes that may render the individual vulnerable to stress and the development of psychopathologies in a sex-specific manner. Earlier we reported lower anxiety-like behavior and higher risk-taking and novelty seeking in rats previously exposed to peripubertal stress. Here we studied whether peri-pubertal stress affected the acquisition and extinction of fear memories and/or the associated functional engagement of various brain regions, as assessed with 2-deoxyglucose. We showed that while peri-pubertal stress reduced freezing during the acquisition of fear memories (training) in both sexes, it had a sex-specific effect on extinction of these memories. Moreover hippocampus, basal amygdala and cingulate and motor cortices showed higher metabolic rates during extinction in rats exposed to peri-pubertal stress. Interestingly, activation of the infralimbic cortex was negatively correlated with freezing during extinction only in control males, while only males stressed during puberty showed a significant correlation between behavior during extinction and metabolic activation of hippocampus, amygdala and paraventricular nucleus. No correlations between brain activation and behavior during extinction were observed in females (control or stress). These results indicate that exposure to peri-pubertal stress affects behavior and brain metabolism when the individual is exposed to an additional stressful challenge. Some of these effects are sex-specific.

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“…We had previously adapted and validated the kit for use with rat EDTA plasma without extraction (Pryce et al, 2003). The assay principle was competitive, equilibrium RIA, with an antiserum of rabbit anti-ACTH, 125 I-ACTH as trace, and goat anti-rabbit serum as precipitating complex.…”

Section: Ria Of Acth and Corticosterone And Fluorescent Eia Of Crf Imentioning

confidence: 99%

Endocrine and behavioural responses to acute central CRF challenge are antagonized in the periphery and CNS, respectively, in C57BL/6 mice

Pryce¹,

Siegl²,

Mayer³

et al. 2011

Neuropharmacology

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Corticotropin releasing factor (CRF) is a major mediator of central and peripheral responses to environmental stressors, and antagonism of its receptors (CRF-R1, -R2) is an active area of pharmacotherapeutic research for stress-related disorders. Stress responses include CRF activation of the hypothalamus-pituitary-adrenal axis and behavioural inhibition. Valid in vivo models for the study of these neuro-endocrine and -behavioural CRF pathways and their central-peripheral antagonism are important. The aims of this study in C57BL/6 mice were to describe the acute effects of intracerebroventricular (ICV) CRF using plasma ACTH-CORT titres and locomotor activity as readouts, and to study the impact on these readouts of central versus peripheral pretreatment with the CRF-R1/2 antagonist, astressin. The following experiments were performed: Effects of (i) serial blood sampling (SBS) per se, (ii) physical confinement + SBS, (iii) ICV saline infusion + SBS, on plasma titres of ACTH-CORT. (iii) ICV saline infusion led to a marked increase in plasma ACTH, possibly due to assay crossreactivity with "washed out" pituitary peptides, and a mild increase in plasma CORT. (iv) ICV CRF (0.001-1 µg) induced no further increase in plasma ACTH versus vehicle, and induced dose-dependent increased plasma CORT. 1 µg ICV CRF also reduced locomotor activity. (v) ICV CRF induced dose-dependent increased plasma CRF. (vi) ICV astressin failed to block ICV CRF-induced increased plasma CORT, whereas IP astressin did do so. (vii) ICV CRF-induced locomotor inactivity was blocked by ICV astressin, but not by IP astressin. Therefore, ICV CRF induced a dose-dependent increase in plasma CORT via a peripheral pathway and a reduction in locomotion via a central pathway, indicated by the double dissociation in the ability of astressin to antagonize these effects relative to its route of administration, IP or ICV, respectively. The preparation described here could be readily used to provide initial indications on the central and peripheral activity of CRF-R antagonists, including pharmacokinetics following peripheral administration.Dear Ms. Yeates, Dear Prof. Markou, Thank you very much to you and the reviewers for the very constructive and helpful criticism of the manuscript. All of the comments have been taken into account and the manuscript has been revised accordingly. The details of the revisions undertaken are stated point-by-point below. The changes made in the revised manuscript relative to the original are highlighted in bold font in the revision.My co-authors and I look forward to your reply on the suitability of the revised manuscript for publication in Neuropharmacology in due course. Thank you and yours sincerely, Christopher PryceCover letter Responses to ReviewersEditor's comments:Both reviewers found your work mostly well conducted and of potential interest to the field. There are, however, some issues that the reviewers raised that need to be addressed with specific changes in the manuscript. For example, the limitation of dr...

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Comparison of the effects of early handling and early deprivation on conditioned stimulus, context, and spatial learning and memory in adult rats.

Cited by 119 publications

References 61 publications

Circadian‐ and temperature‐specific effects of early deprivation on rat maternal care and pup development: Short‐term markers for long‐term effects?

Circadian‐ and temperature‐specific effects of early deprivation on rat maternal care and pup development: Short‐term markers for long‐term effects?

Stress during puberty boosts metabolic activation associated with fear-extinction learning in hippocampus, basal amygdala and cingulate cortex

Endocrine and behavioural responses to acute central CRF challenge are antagonized in the periphery and CNS, respectively, in C57BL/6 mice

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