Comparison of the effects of guanadrel sulfate and propranolol on blood pressure, functional capacity, serum lipoproteins and glucose in systemic hypertension

Darga, Linda L.; Hakim, Mark J.; Lucas, Charles; Franklin, Barry A.

doi:10.1016/0002-9149(91)90897-t

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Blockages of the peripheral β -adrenergic receptors with propranolol, a nonselective β -adrenergic receptors' blocker [35], caused a significant attenuation in met-AESP-induced hypotension. Hence, it is suggested that met-AESP partially acted via β -adrenergic receptors of the ANS.…”

Section: Discussionmentioning

confidence: 99%

Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts ofSyzygium polyanthum(Wight) Walp. var.polyanthumLeaves in Anaesthetized Rats

Ismail

Mohamed

Sulaiman

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia (n = 5). AESP-induced hypotension was more potent than that of met-AESP in WKY. AESP has a faster onset time than that of met-AESP in both WKY and SHR. However, met-AESP-induced hypotension was more sustained than that of AESP in SHR. Blockages of autonomic ganglion and α-adrenergic receptors using hexamethonium and phentolamine (n = 5 for each group) partially attenuated AESP-induced hypotension, suggesting involvement of α-adrenergic receptors. Blockages of autonomic ganglion, β-adrenergic, cholinergic receptors, and nitric oxide production using hexamethonium, propranolol, atropine, and N-ω-nitro-l arginine methyl ester (L-NAME) (n = 5 for each group) partially attenuated met-AESP-induced hypotension, suggesting involvement of β-adrenergic and cholinergic receptors via nitric oxide production.

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Section: Discussionmentioning

confidence: 99%

Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts ofSyzygium polyanthum(Wight) Walp. var.polyanthumLeaves in Anaesthetized Rats

Ismail

Mohamed

Sulaiman

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The effect of beta‐blockade therapy on the response to exercise training in postmyocardial infarction patients

Pavia

Orlando

Myers

et al. 1995

Clinical Cardiology

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Summary: Cardiac rehabilitation after a myocardial infarction has been shown to improve exercise capacity. Beta blockade has been shown to be effective in treating angina and reducing mortality, but studies are controversial as to whether beta-blockade therapy attenuates the effects of training. We attempted to study the effects of beta blockade (metoprolol) on the response to training in patients enrolled in a cardiac rehabilitation program after an uncomplicated myocardial inf'arction. We studied 27 patients with a recent uncomplicated myocardial infarction who were subdivided in two groups: Group 1 ( I3 patients) not taking a beta blocker, and Group 2 ( 14 patients) taking metoprolol (mean 142 2 57 mg daily). All patients underwent a maximal cardiopulmonary exercise test before and after a 3-month training program. The training intensity was designed to approximate the ventilatory threshold. Results showed an increase in peak VO? in both Group 1 (27%1, p<0.01)andGroup2(33%, p

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Effect of timolol on cardiopulmonary exercise performance in men after myocardial infarction

Barvik¹,

Dickstein²,

Aarsland³

et al. 1992

The American Journal of Cardiology

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Comparison of the effects of guanadrel sulfate and propranolol on blood pressure, functional capacity, serum lipoproteins and glucose in systemic hypertension

Cited by 7 publications

References 26 publications

Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts ofSyzygium polyanthum(Wight) Walp. var.polyanthumLeaves in Anaesthetized Rats

Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts ofSyzygium polyanthum(Wight) Walp. var.polyanthumLeaves in Anaesthetized Rats

The effect of beta‐blockade therapy on the response to exercise training in postmyocardial infarction patients

Effect of timolol on cardiopulmonary exercise performance in men after myocardial infarction

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