Comparison of the Effects of Frontal and Temporal Lobe Partial Seizures on Prolactin Levels

Meierkord, Hartmut; Shorvon, Simon; Lightman, Stafford L.; Trimble, M R

doi:10.1001/archneur.1992.00530270039016

Cited by 46 publications

(14 citation statements)

References 30 publications

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“…The abundance of projections from the medial temporal lobe to other areas in the brain (including the hypothalamus) may explain the activation of cytokine cascade specifically in TLE. An older finding of increased secretion of prolactin in TLE may support this hypothesis [41].…”

Section: Discussionmentioning

confidence: 92%

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

et al. 2009

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Previous studies have reported activation of inflammatory cytokines in seizures, but clinical characteristics of epilepsy associated with cytokine activation have not been well established. In this study, serum levels of interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1RA) were measured, and clinical characteristics of epilepsy were assessed in 86 well-evaluated patients with refractory focal epilepsy and in 5 patients with controlled focal epilepsy. Epilepsy was evaluated based on patient histories, electroclinical findings, and high-resolution brain MRI scans. Sixty-three healthy blood donors served as controls. IL-6 concentrations were chronically increased in epilepsy patients (11%) compared with healthy controls (0%) (P = 0.007). Increased levels of IL-6 were more prevalent in patients with temporal lobe epilepsy (TLE) compared to patients with extra-TLE (P = 0.028). Also the mean and the median serum levels of IL-6 were higher in patients with TLE than in patients with extra-TLE (P = 0.042). Concentrations of IL-1RA were not significantly different in patients compared with controls. Indicated by increased levels of IL-6 in TLE, epilepsy type is important in determining chronic overproduction of cytokines in refractory focal epilepsy. The results may reflect a chronic immunological process in the brain in patients with refractory epilepsy.

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Section: Discussionmentioning

confidence: 92%

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

et al. 2009

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“…It is less frequently abnormal after focal seizures. Frontal lobe seizures may be too brief to result in a change in prolactin levels [66]. Also, there is an increased rate of false-positives in the psychiatric population resulting from the intake of psychotropic medications.…”

Section: Differential Diagnosis and Distinction From Psychiatric Disomentioning

confidence: 99%

Frontal Lobe Seizures

Jobst

Williamson

2005

Psychiatric Clinics of North America

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“…Potentially suggestive of a dissociative diagnosis are a personal and family history of psychiatric illness and the presence of comorbid psychopathology,19 a family history of epilepsy,19 and evidence of clear psychosocial seizure precipitants 12 Raised postictal serum prolactin concentrations (greater than 1000 IU/l) in the presence of normal baseline values are found after epileptic seizures,20although this is limited to certain seizure types21; moreover, false positives can occur (for example, with syncope). Self injury is common in both epileptic and dissociative seizures, although the site and severity of lesions often differ between the two.…”

Section: Dissociative Convulsions (Non-epileptic Seizures)mentioning

confidence: 99%

Dissociative psychopathology, non-epileptic seizures, and neurology

Brown

2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Comparison of the Effects of Frontal and Temporal Lobe Partial Seizures on Prolactin Levels

Cited by 46 publications

References 30 publications

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy

Frontal Lobe Seizures

Dissociative psychopathology, non-epileptic seizures, and neurology

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