Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during exercise.

Abstract

Effective renal plasma flow and glomerular filtration rate were measured in 22 mild-tomoderate, uncomplicated, essential hypertensive patients during placebo and after 3 months of randomly assigned treatment either with prizidilol (n = 10) or propranolol (n = 12). Measurements were performed at rest and during cycloergometer exercise. 2 For a comparable effect on blood pressure effective renal plasma flow was significantly increased at rest by prizidilol (+9%) and decreased by propranolol (-13.6%); these patterns were maintained during exercise. Glomerular filtration rate was immodified after the treatment with both drugs. 3 It is concluded that prizidilol is an effective hypotensive agent with no deleterious effects on renal haemodynamics.